JPS55130921A - Albumin microaggregate for radioactive scanning in reticuloendotissue system - Google Patents

Albumin microaggregate for radioactive scanning in reticuloendotissue system

Info

Publication number
JPS55130921A
JPS55130921A JP3540079A JP3540079A JPS55130921A JP S55130921 A JPS55130921 A JP S55130921A JP 3540079 A JP3540079 A JP 3540079A JP 3540079 A JP3540079 A JP 3540079A JP S55130921 A JPS55130921 A JP S55130921A
Authority
JP
Japan
Prior art keywords
albumin
reticuloendotissue
microaggregate
radioactive scanning
reducing metal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3540079A
Other languages
Japanese (ja)
Other versions
JPH0343254B2 (en
Inventor
Eru Sakuratsudo Yuujiin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
New England Nuclear Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Nuclear Corp filed Critical New England Nuclear Corp
Publication of JPS55130921A publication Critical patent/JPS55130921A/en
Publication of JPH0343254B2 publication Critical patent/JPH0343254B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/081—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the protein being an albumin, e.g. human serum albumin [HSA], bovine serum albumin [BSA], ovalbumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1255—Granulates, agglomerates, microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Abstract

Micro aggregates of albumin wherein the albumin particles comprise a reducing metal e.g. tin bound thereto and also Tc-99 m radioactively labeled such microaggregates are useful for imaging of reticuloendothelial systems (RES), especially the liver, spleen and bone marrow. Compositions may also contain a stabilizing ligand for the reducing metal e.g. a phosphonate, phosphate, aminocarboxylate, polyhydroxycarboxylate or polycarboxylates.
JP3540079A 1979-02-22 1979-03-26 Albumin microaggregate for radioactive scanning in reticuloendotissue system Granted JPS55130921A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7906298A GB2042887B (en) 1979-02-22 1979-02-22 Albumin microaggregates for radioactive scanning of reticuloendothelial systems

Publications (2)

Publication Number Publication Date
JPS55130921A true JPS55130921A (en) 1980-10-11
JPH0343254B2 JPH0343254B2 (en) 1991-07-01

Family

ID=10503365

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3540079A Granted JPS55130921A (en) 1979-02-22 1979-03-26 Albumin microaggregate for radioactive scanning in reticuloendotissue system

Country Status (6)

Country Link
JP (1) JPS55130921A (en)
DE (1) DE2909355C2 (en)
FR (1) FR2450611A1 (en)
GB (1) GB2042887B (en)
NL (1) NL190050C (en)
SE (1) SE431286B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846028A (en) * 1981-08-28 1983-03-17 ソリン・ビオメディカ・ソシエタ・ペル・アチオニ Manufacture of radioactive colloid made from human blood serum albumin
JPS59205330A (en) * 1983-04-13 1984-11-20 アメルシヤム・インタ−ナシヨナル・パブリツク・リミテツド・コムパニ− Reagent for producing tin coloid labeled with body scanning technetium-99m

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE463651B (en) * 1983-12-21 1991-01-07 Nycomed As DIAGNOSTIC AND CONTRACTOR
SU1708350A1 (en) * 1988-04-15 1992-01-30 Оренбургский Государственный Медицинский Институт Bacillus subtilis strain as radionuclide carrier
ES2096521B1 (en) * 1994-08-10 1997-11-16 Univ La Laguna BIODEGRADABLE SYNTHETIC POLYMER MICROSPHERES IN THE MANUFACTURE AND ELABORATION OF REACTIVE EQUIPMENT FOR THE PREPARATION OF RADIOPHARMACEUTICAL MEDICINES.
EP1683517A1 (en) * 1996-08-19 2006-07-26 American Bioscience, Inc. Methods for the production of protein particles useful for delivery of pharmacological agents
CN102667487B (en) * 2009-12-10 2014-10-29 希森美康株式会社 Method for detection of basic peptide and reagent for detection of basic peptide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2281134A1 (en) * 1974-08-06 1976-03-05 Commissariat Energie Atomique 99M TECHNETIUM MARKING PROCESS
US3987157A (en) * 1974-08-29 1976-10-19 Union Carbide Corporation Technetium 99-m labeled radio-diagnostic agents employing stannous tartrate and method of preparation
US4094965A (en) * 1977-04-01 1978-06-13 New England Nuclear Corporation Diagnostic agents containing albumin and method for making same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846028A (en) * 1981-08-28 1983-03-17 ソリン・ビオメディカ・ソシエタ・ペル・アチオニ Manufacture of radioactive colloid made from human blood serum albumin
JPH0375534B2 (en) * 1981-08-28 1991-12-02 Solco Basel Ag
JPS59205330A (en) * 1983-04-13 1984-11-20 アメルシヤム・インタ−ナシヨナル・パブリツク・リミテツド・コムパニ− Reagent for producing tin coloid labeled with body scanning technetium-99m
JPH0357086B2 (en) * 1983-04-13 1991-08-30

Also Published As

Publication number Publication date
NL190050C (en) 1993-10-18
DE2909355C2 (en) 1985-09-12
DE2909355A1 (en) 1980-09-11
SE7902009L (en) 1980-09-07
FR2450611B1 (en) 1983-02-25
NL190050B (en) 1993-05-17
FR2450611A1 (en) 1980-10-03
GB2042887B (en) 1983-10-12
SE431286B (en) 1984-01-30
NL7901767A (en) 1980-09-09
JPH0343254B2 (en) 1991-07-01
GB2042887A (en) 1980-10-01

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