WO1991010645A3 - Chelants - Google Patents

Chelants

Info

Publication number
WO1991010645A3
WO1991010645A3 PCT/EP1991/000126 EP9100126W WO9110645A3 WO 1991010645 A3 WO1991010645 A3 WO 1991010645A3 EP 9100126 W EP9100126 W EP 9100126W WO 9110645 A3 WO9110645 A3 WO 9110645A3
Authority
WO
WIPO (PCT)
Prior art keywords
chelants
radiotherapeutic
preparation
chelating agents
agents useful
Prior art date
Application number
PCT/EP1991/000126
Other languages
French (fr)
Other versions
WO1991010645A2 (en
Inventor
Joan F Carvalho
Shaun P Crofts
Scott M Rocklage
Original Assignee
Cockbain Julian R M
Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cockbain Julian R M, Salutar Inc filed Critical Cockbain Julian R M
Priority to CA002074171A priority Critical patent/CA2074171A1/en
Priority to JP91502458A priority patent/JPH05506426A/en
Publication of WO1991010645A2 publication Critical patent/WO1991010645A2/en
Publication of WO1991010645A3 publication Critical patent/WO1991010645A3/en
Priority to FI923286A priority patent/FI923286A0/en
Priority to NO92922849A priority patent/NO922849L/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/228—Host-guest complexes, clathrates, chelates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Acoustics & Sound (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

There are provided novel chelating agents useful in the preparation of contrast media for diagnostic imaging or of radiotherapeutic or detoxification compositions.
PCT/EP1991/000126 1990-01-19 1991-01-18 Chelants WO1991010645A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002074171A CA2074171A1 (en) 1990-01-19 1991-01-18 Chelants
JP91502458A JPH05506426A (en) 1990-01-19 1991-01-18 chelating agent
FI923286A FI923286A0 (en) 1990-01-19 1992-07-17 KELATERINGSAEMNEN.
NO92922849A NO922849L (en) 1990-01-19 1992-07-17 Chelating agents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001245A GB9001245D0 (en) 1990-01-19 1990-01-19 Compounds
GB9001245.1 1990-01-19

Publications (2)

Publication Number Publication Date
WO1991010645A2 WO1991010645A2 (en) 1991-07-25
WO1991010645A3 true WO1991010645A3 (en) 1991-12-26

Family

ID=10669570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/000126 WO1991010645A2 (en) 1990-01-19 1991-01-18 Chelants

Country Status (10)

Country Link
EP (1) EP0527131A1 (en)
JP (1) JPH05506426A (en)
AU (1) AU7060291A (en)
CA (1) CA2074171A1 (en)
FI (1) FI923286A0 (en)
GB (1) GB9001245D0 (en)
HU (1) HUT61306A (en)
IE (1) IE910189A1 (en)
NO (1) NO922849L (en)
WO (1) WO1991010645A2 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
FR2644785B1 (en) * 1989-03-24 1991-07-05 Guerbet Sa NOVEL NITROGEN MACROCYCLIC LIGANDS, PROCESS FOR THEIR PREPARATION, METAL COMPLEXES FORMED BY SUCH LIGANDS AND DIAGNOSTIC COMPOSITION CONTAINING THEM
US5367080A (en) * 1990-11-08 1994-11-22 Sterling Winthrop Inc. Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods
CA2072934C (en) * 1991-07-19 2007-08-28 Karl William Aston Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0735040A3 (en) * 1991-12-10 1997-02-26 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
WO1993011741A1 (en) * 1991-12-10 1993-06-24 The Dow Chemical Company Oral compositions for inhibiting plaque and calculus formation
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
ZA929575B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclocarboxyclic acid complexes,their conjugates,processes for their preparation,and use as contrast agents
EP0639083B1 (en) * 1992-05-07 2001-07-18 Nycomed Imaging As Complexing agents and targeting immunoreagents
WO1994026755A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes, a process for their preparation, and their conjugates, for use as radiopharmaceuticals
EP0696290A1 (en) * 1993-05-06 1996-02-14 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
WO1994026315A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5476644A (en) * 1994-04-13 1995-12-19 Sterling Winthrop Inc. Cyclic triamine chelating agents
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) * 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc Nitrogenous macrocyclic compounds
US6525041B1 (en) 1995-06-06 2003-02-25 Pharmacia Corporation Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide
EP0846003A1 (en) 1995-08-17 1998-06-10 Monsanto Company Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands
JPH11514971A (en) * 1995-08-17 1999-12-21 モンサント カンパニー Diagnostic imaging method using metal complex of nitrogen-containing macrocyclic ligand
GB9702978D0 (en) * 1997-02-13 1997-04-02 Ciba Geigy Compounds
US6214817B1 (en) 1997-06-20 2001-04-10 Monsanto Company Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity
ES2725023T3 (en) 2006-10-12 2019-09-18 Galera Labs Llc Methods for the treatment of oral mucositis
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
CN103906756B (en) 2011-09-26 2020-03-03 加莱拉实验室有限责任公司 Methods for treating diseases
DK2988756T4 (en) * 2013-04-26 2022-08-08 Guerbet Sa FORMULATION OF CONTRAST SUBSTANCE AND RELATED MANUFACTURING PROCESS
HUE049926T2 (en) 2015-08-11 2020-11-30 Galera Labs Llc Pentaaza macrocyclic ring complexes possessing oral bioavailability
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
IL295620B2 (en) 2017-04-13 2024-01-01 Galera Labs Llc Combination cancer immunotherapy with pentaaza macrocyclic ring complex

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751390A (en) * 1950-09-02 1956-06-19 Dow Chemical Co Di-pyridyl aliphatic alkylene polyamine poly acids
WO1986006605A1 (en) * 1985-05-08 1986-11-20 The General Hospital Corporation Hepatobiliary nmr contrast agents
WO1989011868A1 (en) * 1988-05-31 1989-12-14 Coulter Electronics, Inc. Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities
EP0352218A2 (en) * 1988-07-20 1990-01-24 Schering Aktiengesellschaft Macrocyclic polyaza compounds containing rings with 5 or 6 members, methods for their preparation and pharmaceutical compositions containing same
WO1990011282A1 (en) * 1989-03-24 1990-10-04 Guerbet S.A. Nitrogenous macrocyclic ligands and their metallic complexes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751390A (en) * 1950-09-02 1956-06-19 Dow Chemical Co Di-pyridyl aliphatic alkylene polyamine poly acids
WO1986006605A1 (en) * 1985-05-08 1986-11-20 The General Hospital Corporation Hepatobiliary nmr contrast agents
WO1989011868A1 (en) * 1988-05-31 1989-12-14 Coulter Electronics, Inc. Macrocyclic complexes of yttrium, the lanthanides and the actinides having peripheral coupling functionalities
EP0352218A2 (en) * 1988-07-20 1990-01-24 Schering Aktiengesellschaft Macrocyclic polyaza compounds containing rings with 5 or 6 members, methods for their preparation and pharmaceutical compositions containing same
WO1990011282A1 (en) * 1989-03-24 1990-10-04 Guerbet S.A. Nitrogenous macrocyclic ligands and their metallic complexes

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, vol. 113, no. 7, 13 August 1990, (Columbus, Ohio, US), K.I. Dhont et al: "Metal ion template synthesis of the macrocyclic multidentate polyamine ligand: 3,6,14,17,23,24-hexa azatricyclo(17.3.1.1 8,12)tetraeicosa-1(22),8(9), 10,12,19,20-hexaene", abstract 59129d & Bull. Soc. Chim. Belg. 1989, 98(8),575-6, see reg no 127503-08-6 *
Helvetica Chimica Acta, vol. 72, August 1989, M.W. Hosseini et al: "Synthesis of polyaza macrocyclic ligands incorporating pyridine units", pages 1066-1077, see especially compounds 4, 5, 21 and 22 *
Inorg. Chem., vol. 25, no. 4, 1986, E.K. Barefield et al: "Electrochemical and Structural Studies of Nickel(II) Complexes of N-Alkylated Cyclam Ligands: X-ray Structures of trans-/Ni(C14H32N4)(OH2)2/ Cl2.2H2O and /Ni(C14H32N4)/(O3SCF3)2", pages 552-558, see compound D *
J. Am. Chem. Soc., vol. 110, no. 9, 1988, R.D. Hancock et al: "More rigid Macrocyclic Ligands That Show Metal Ion Size-Based Selectivity. A Crystallographic, Molecular Mechanics, and Formation Constant Study of the Complexes of BridgedCyclen", pages 2788-2794, see tables I and VI *
J. Am. Chem. Soc., vol. 111, September 1989, P.H. Smith et al: "Solution and solid-state characterization of Europium and Gadolinium schiff base complexes and assessment of their potential as contrast agents in magnetic resonance imaging", pages 7437-7443, see the whole article *
J. Am. Chem. Soc., vol.87, 1965, R.G. Lacoste et al: "New Multidentate Ligands. II. Amino Acids Containing alfa-Pyridyl Groups", pages 2385-2388, see the whole document *
J. Chem. Soc. Dalton Trans., December 1988, N.W. Alcock et al:"Synthesis and Co-ordination Chemistry of Two Penta-azamacrocycles containing a 1,4-Piperazine Backbone. Crystal Structure Determinations of 6,12-Dioxo-1,5,13,17,22-penta- -azatricyclo/15.2.2.1 7,11/docosa-7(22),8,10- -triene and 1,5,13,17,22-Penta-azatricyclo /15.2.2.1 7,11/docosa-7(22),8,10-trienenickel(II) Perchlorate", pages 2959-2963, see compound L2 and tables 1 and 2 *
J. Chem. Soc., Chem. Commun., 1982, A. Ramasubbu et al: "Structurally Reinforced Cyclen: A Rigidly trans-Co-ordinating Twelve-membered Macrocycle", pages 277-278, see compound 2 *
J. Chem. Soc., Chem. Commun., 1985, N.W. Alcock et al: "Co-ordination to Copper(II) by OnlyThree Nitrogen Atoms of a Tetra-azamacro- cyclic Ligand functionalised with Two Pendant Acetate-arms. X-Ray Structure of /Cu(L1H2)Cl/Cl, where L1 is 3,11-Diacetato-7-methyl-3,7,11,17- -tetraazabicyclo/11.3.1/heptadeca-1(17),13,15- -triene", pages 1058-1059, see compound L1 *
J. Phys. Chem., vol. 91, no. 18, 1987, N. Sabbatini et al: "Radiative and Nonradiative Transitions in the Eu(III) Hexaaza Macrocyclic Complex /Eu(C22H26N6)(CH3COO)/(CH3COO)Cl.2H2O pages 4681-4685, see the whole document *
Tetrahedron, vol. 37, 1981, H. Stetter et al: "Darstellung und Komplexbildung von Polyazacyclo- alkan-N-Essigs{uren, pages 767-772, see especially compounds 19 and 31 *

Also Published As

Publication number Publication date
FI923286A (en) 1992-07-17
CA2074171A1 (en) 1991-07-20
HU9202347D0 (en) 1992-10-28
EP0527131A1 (en) 1993-02-17
HUT61306A (en) 1992-12-28
FI923286A0 (en) 1992-07-17
GB9001245D0 (en) 1990-03-21
IE910189A1 (en) 1991-07-31
AU7060291A (en) 1991-08-05
NO922849L (en) 1992-09-04
WO1991010645A2 (en) 1991-07-25
JPH05506426A (en) 1993-09-22
NO922849D0 (en) 1992-07-17

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