GB202013141D0 - A screening method for the detection of DNA damage - Google Patents

A screening method for the detection of DNA damage

Info

Publication number
GB202013141D0
GB202013141D0 GBGB2013141.3A GB202013141A GB202013141D0 GB 202013141 D0 GB202013141 D0 GB 202013141D0 GB 202013141 A GB202013141 A GB 202013141A GB 202013141 D0 GB202013141 D0 GB 202013141D0
Authority
GB
United Kingdom
Prior art keywords
detection
screening method
dna damage
dna
damage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB2013141.3A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Cardiff Consultants Ltd
Original Assignee
University College Cardiff Consultants Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=72660690&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB202013141(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University College Cardiff Consultants Ltd filed Critical University College Cardiff Consultants Ltd
Priority to GBGB2013141.3A priority Critical patent/GB202013141D0/en
Publication of GB202013141D0 publication Critical patent/GB202013141D0/en
Priority to EP21766455.6A priority patent/EP4200443B1/en
Priority to IL300674A priority patent/IL300674A/en
Priority to CA3188635A priority patent/CA3188635A1/en
Priority to ES21766455T priority patent/ES2984253T3/es
Priority to AU2021328724A priority patent/AU2021328724A1/en
Priority to FIEP21766455.6T priority patent/FI4200443T3/fi
Priority to DK21766455.6T priority patent/DK4200443T3/da
Priority to KR1020237009611A priority patent/KR20230057395A/ko
Priority to US18/042,193 priority patent/US20240011095A1/en
Priority to EP24165314.6A priority patent/EP4368725B1/en
Priority to PCT/EP2021/073203 priority patent/WO2022038291A1/en
Priority to CN202180072261.2A priority patent/CN116472356A/zh
Priority to JP2023512403A priority patent/JP2023539169A/ja
Priority to US18/620,640 priority patent/US12428683B2/en
Priority to US18/620,644 priority patent/US12421554B2/en
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301—Endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/307—Single strand endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/155—Modifications characterised by incorporating/generating a new priming site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/186—Modifications characterised by incorporating a non-extendable or blocking moiety
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/191—Modifications characterised by incorporating an adaptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2535/00—Reactions characterised by the assay type for determining the identity of a nucleotide base or a sequence of oligonucleotides
    • C12Q2535/122—Massive parallel sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
GBGB2013141.3A 2020-08-21 2020-08-21 A screening method for the detection of DNA damage Ceased GB202013141D0 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
GBGB2013141.3A GB202013141D0 (en) 2020-08-21 2020-08-21 A screening method for the detection of DNA damage
CN202180072261.2A CN116472356A (zh) 2020-08-21 2021-08-20 用于分离双链断裂的方法
JP2023512403A JP2023539169A (ja) 2020-08-21 2021-08-20 二本鎖切断を単離するための方法
DK21766455.6T DK4200443T3 (da) 2020-08-21 2021-08-20 Fremgangsmåde til isolering af dobbeltstrengsbrud
KR1020237009611A KR20230057395A (ko) 2020-08-21 2021-08-20 이중 가닥 파손의 단리 방법
CA3188635A CA3188635A1 (en) 2020-08-21 2021-08-20 A method for the isolation of double-strand breaks
ES21766455T ES2984253T3 (es) 2020-08-21 2021-08-20 Un método para el aislamiento de roturas de doble hebra
AU2021328724A AU2021328724A1 (en) 2020-08-21 2021-08-20 A method for the isolation of double-strand breaks
FIEP21766455.6T FI4200443T3 (fi) 2020-08-21 2021-08-20 Menetelmä kaksoisjuosteen katkosten eristämiseksi
EP21766455.6A EP4200443B1 (en) 2020-08-21 2021-08-20 A method for the isolation of double-strand breaks
IL300674A IL300674A (en) 2020-08-21 2021-08-20 A method for isolating double-strand breaks
US18/042,193 US20240011095A1 (en) 2020-08-21 2021-08-20 A method for the isolation of double-strand breaks
EP24165314.6A EP4368725B1 (en) 2020-08-21 2021-08-20 A method for the isolation of double-strand breaks
PCT/EP2021/073203 WO2022038291A1 (en) 2020-08-21 2021-08-20 A method for the isolation of double-strand breaks
US18/620,644 US12421554B2 (en) 2020-08-21 2024-03-28 Method for the isolation of double-strand breaks
US18/620,640 US12428683B2 (en) 2020-08-21 2024-03-28 Method for the isolation of double-strand breaks

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB2013141.3A GB202013141D0 (en) 2020-08-21 2020-08-21 A screening method for the detection of DNA damage

Publications (1)

Publication Number Publication Date
GB202013141D0 true GB202013141D0 (en) 2020-10-07

Family

ID=72660690

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB2013141.3A Ceased GB202013141D0 (en) 2020-08-21 2020-08-21 A screening method for the detection of DNA damage

Country Status (13)

Country Link
US (3) US20240011095A1 (https=)
EP (2) EP4368725B1 (https=)
JP (1) JP2023539169A (https=)
KR (1) KR20230057395A (https=)
CN (1) CN116472356A (https=)
AU (1) AU2021328724A1 (https=)
CA (1) CA3188635A1 (https=)
DK (1) DK4200443T3 (https=)
ES (1) ES2984253T3 (https=)
FI (1) FI4200443T3 (https=)
GB (1) GB202013141D0 (https=)
IL (1) IL300674A (https=)
WO (1) WO2022038291A1 (https=)

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Publication number Priority date Publication date Assignee Title
GB202013141D0 (en) 2020-08-21 2020-10-07 Univ College Cardiff Consultants Ltd A screening method for the detection of DNA damage
GB202209189D0 (en) 2022-06-22 2022-08-10 Broken String Biosciences Ltd Methods and compositions for nucleic acid sequencing
EP4569135A1 (en) 2022-08-09 2025-06-18 Institute of Molecular Biology gGmbH (IMB) Method of parallel, rapid and sensitive detection of dna double strand breaks
EP4321630A1 (en) * 2022-08-09 2024-02-14 Institute of Molecular Biology gGmbH (IMB) Method of parallel, rapid and sensitive detection of dna double strand breaks
GB202319988D0 (en) 2023-12-22 2024-02-07 Broken String Biosciences Ltd Methods of detecting dsbs and mutations

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WO2011086118A1 (en) 2010-01-14 2011-07-21 Deutsches Krebsforschungszentrum In vivo determination of the lokalization of dna double-stand breaks and application thereof
US8951781B2 (en) 2011-01-10 2015-02-10 Illumina, Inc. Systems, methods, and apparatuses to image a sample for biological or chemical analysis
WO2013006745A2 (en) 2011-07-07 2013-01-10 Immune Disease Institute, Inc. High throughput genome-wide translocation sequencing
RU2694686C2 (ru) 2013-03-12 2019-07-16 Е.И.Дюпон Де Немур Энд Компани Способы идентификации вариантных сайтов распознавания для редкощепящих сконструированных средств для индукции двунитевого разрыва, и композиции с ними, и их применения
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Also Published As

Publication number Publication date
EP4368725A2 (en) 2024-05-15
EP4200443B1 (en) 2024-04-10
FI4200443T3 (fi) 2024-07-11
CN116472356A (zh) 2023-07-21
EP4368725A3 (en) 2024-05-29
IL300674A (en) 2023-04-01
AU2021328724A9 (en) 2023-04-27
EP4200443A1 (en) 2023-06-28
US20240309454A1 (en) 2024-09-19
US20240309455A1 (en) 2024-09-19
JP2023539169A (ja) 2023-09-13
US20240011095A1 (en) 2024-01-11
ES2984253T3 (es) 2024-10-29
WO2022038291A1 (en) 2022-02-24
CA3188635A1 (en) 2022-02-24
DK4200443T3 (da) 2024-07-22
EP4368725B1 (en) 2026-03-04
AU2021328724A1 (en) 2023-03-30
KR20230057395A (ko) 2023-04-28
US12428683B2 (en) 2025-09-30
US12421554B2 (en) 2025-09-23

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AT Applications terminated before publication under section 16(1)