GB201718804D0 - Novel use - Google Patents

Novel use

Info

Publication number
GB201718804D0
GB201718804D0 GBGB1718804.6A GB201718804A GB201718804D0 GB 201718804 D0 GB201718804 D0 GB 201718804D0 GB 201718804 A GB201718804 A GB 201718804A GB 201718804 D0 GB201718804 D0 GB 201718804D0
Authority
GB
United Kingdom
Prior art keywords
novel use
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1718804.6A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuclera Ltd
Original Assignee
Nuclera Nucleics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nuclera Nucleics Ltd filed Critical Nuclera Nucleics Ltd
Priority to GBGB1718804.6A priority Critical patent/GB201718804D0/en
Publication of GB201718804D0 publication Critical patent/GB201718804D0/en
Priority to US16/191,109 priority patent/US11505815B2/en
Priority to CN201880073408.8A priority patent/CN111344296A/zh
Priority to JP2020544181A priority patent/JP2021503003A/ja
Priority to AU2018366391A priority patent/AU2018366391A1/en
Priority to PCT/GB2018/053305 priority patent/WO2019097233A1/en
Priority to GB1818605.6A priority patent/GB2568397A/en
Priority to EP18811609.9A priority patent/EP3710461A1/en
Priority to CA3082429A priority patent/CA3082429A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07031—DNA nucleotidylexotransferase (2.7.7.31), i.e. terminal deoxynucleotidyl transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/117—Modifications characterised by incorporating modified base

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GBGB1718804.6A 2017-11-14 2017-11-14 Novel use Ceased GB201718804D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
GBGB1718804.6A GB201718804D0 (en) 2017-11-14 2017-11-14 Novel use
US16/191,109 US11505815B2 (en) 2017-11-14 2018-11-14 Compositions and methods related to non-templated enzymatic nucleic acid synthesis
CN201880073408.8A CN111344296A (zh) 2017-11-14 2018-11-14 含有胺掩蔽的部分的核苷酸衍生物及其在模板化和非模板化酶促核酸合成中的用途
JP2020544181A JP2021503003A (ja) 2017-11-14 2018-11-14 アミン保護された部分を含むヌクレオチド誘導体、並びに鋳型依存性及び鋳型非依存性酵素的核酸合成におけるそれらの使用
AU2018366391A AU2018366391A1 (en) 2017-11-14 2018-11-14 Nucleotide derivatives containing amine masked moieties and their use in a templated and non-templated enzymatic nucleic acid synthesis
PCT/GB2018/053305 WO2019097233A1 (en) 2017-11-14 2018-11-14 Nucleotide derivatives containing amine masked moieties and their use in a templated and non-templated enzymatic nucleic acid synthesis
GB1818605.6A GB2568397A (en) 2017-11-14 2018-11-14 Novel use
EP18811609.9A EP3710461A1 (en) 2017-11-14 2018-11-14 Nucleotide derivatives containing amine masked moieties and their use in a templated and non-templated enzymatic nucleic acid synthesis
CA3082429A CA3082429A1 (en) 2017-11-14 2018-11-14 Nucleotide derivatives containing amine masked moieties and their use in a templated and non-templated enzymatic nucleic acid synthesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1718804.6A GB201718804D0 (en) 2017-11-14 2017-11-14 Novel use

Publications (1)

Publication Number Publication Date
GB201718804D0 true GB201718804D0 (en) 2017-12-27

Family

ID=60788377

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB1718804.6A Ceased GB201718804D0 (en) 2017-11-14 2017-11-14 Novel use
GB1818605.6A Withdrawn GB2568397A (en) 2017-11-14 2018-11-14 Novel use

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1818605.6A Withdrawn GB2568397A (en) 2017-11-14 2018-11-14 Novel use

Country Status (8)

Country Link
US (1) US11505815B2 (https=)
EP (1) EP3710461A1 (https=)
JP (1) JP2021503003A (https=)
CN (1) CN111344296A (https=)
AU (1) AU2018366391A1 (https=)
CA (1) CA3082429A1 (https=)
GB (2) GB201718804D0 (https=)
WO (1) WO2019097233A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019311199B2 (en) 2018-07-23 2024-12-19 Dna Script Massively parallel enzymatic synthesis of nucleic acid strands
SG11202105441WA (en) 2018-12-13 2021-06-29 Dna Script Direct oligonucleotide synthesis on cells and biomolecules
SG11202107921SA (en) 2019-02-12 2021-08-30 Dna Script Efficient product cleavage in template-free enzymatic synthesis of polynucleotides.
WO2020165334A1 (en) * 2019-02-14 2020-08-20 Dna Script Process for preparing 3'-o-amino-ribonucleotide
GB201906772D0 (en) * 2019-05-14 2019-06-26 Nuclera Nucleics Ltd Nucleic acid polymer with amine-masked bases
EP4126895A1 (en) * 2020-03-30 2023-02-08 DNA Script Method for preparing 3'-o-amino-2'-deoxyribonucleoside-5'-triphosphates
EP4132941A2 (en) * 2020-04-06 2023-02-15 Nuclera Nucleics Ltd 3'-aminooxy-c5-substituted cytosine nucleotide derivatives and their use in a templated and non-templated enzymatic nucleic acid synthesis
GB202005043D0 (en) * 2020-04-06 2020-05-20 Nuclera Nucleics Ltd C5-modified Thymidines
US11850258B1 (en) * 2020-05-29 2023-12-26 Nilesh B. Karalkar Ribonucleoside derivatives with 3′-aminoxy groups
WO2024227846A2 (en) 2023-05-03 2024-11-07 Dna Script Reagent used in deprotection of 3'-o-amino polynucleotides
CN116949152B (zh) * 2023-06-16 2025-03-11 广州国家实验室 一种单碱基水平检测基因组DNA上N4-mC及5mC修饰的测序方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3022967B2 (ja) * 1985-03-15 2000-03-21 アンチバイラルズ インコーポレイテッド 立体規則性ポリヌクレオチド結合ポリマー
US4672111A (en) * 1985-04-23 1987-06-09 University Of Wyoming 5-azido-deoxyuridine compounds and method of synthesis of the same
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel
JPH11512397A (ja) * 1995-09-07 1999-10-26 ユニバーシティー オブ ジョージア リサーチ ファウンデーション，インコーポレイテッド 治療用アジド化合物
IT1377936B1 (it) 2007-03-28 2010-07-30 Nucleotidi piridinici acitali, loro reparazione ed uso
JP2011520845A (ja) * 2008-05-15 2011-07-21 カソリック ユニヴェルシテイト ルーヴェン，ケー．ユー． ルーヴェン アール アンド ディー 抗癌剤の組合せによる治療
US8034923B1 (en) * 2009-03-27 2011-10-11 Steven Albert Benner Reagents for reversibly terminating primer extension
US9309569B2 (en) * 2010-08-26 2016-04-12 Intelligent Bio-Systems, Inc. Methods and compositions for sequencing nucleic acid using charge
KR101794970B1 (ko) * 2010-11-12 2017-11-07 (주)비씨월드제약 신규한 뉴클레오시드 유도체
KR101093787B1 (ko) * 2011-06-10 2011-12-19 (주)비씨월드제약 신규한 뉴클레오시드 유도체를 포함하는 암 치료용 약학적 조성물
GB201502152D0 (en) * 2015-02-10 2015-03-25 Nuclera Nucleics Ltd Novel use
WO2017087887A1 (en) * 2015-11-18 2017-05-26 The Trustees Of Columbia University In The City Of New York Ion sensor dna and rna sequencing by synthesis using nucleotide reversible terminators

Also Published As

Publication number Publication date
EP3710461A1 (en) 2020-09-23
WO2019097233A1 (en) 2019-05-23
CA3082429A1 (en) 2019-05-23
GB201818605D0 (en) 2018-12-26
AU2018366391A1 (en) 2020-06-25
GB2568397A (en) 2019-05-15
US11505815B2 (en) 2022-11-22
US20190144905A1 (en) 2019-05-16
JP2021503003A (ja) 2021-02-04
CN111344296A (zh) 2020-06-26

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Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)