GB201507036D0 - Crystalline enzyme inhibitor compound - Google Patents

Crystalline enzyme inhibitor compound

Info

Publication number
GB201507036D0
GB201507036D0 GBGB1507036.0A GB201507036A GB201507036D0 GB 201507036 D0 GB201507036 D0 GB 201507036D0 GB 201507036 A GB201507036 A GB 201507036A GB 201507036 D0 GB201507036 D0 GB 201507036D0
Authority
GB
United Kingdom
Prior art keywords
inhibitor compound
enzyme inhibitor
crystalline enzyme
crystalline
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1507036.0A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BenevolentAI Cambridge Ltd
Original Assignee
Proximagen Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Proximagen Ltd filed Critical Proximagen Ltd
Priority to GBGB1507036.0A priority Critical patent/GB201507036D0/en
Publication of GB201507036D0 publication Critical patent/GB201507036D0/en
Priority to TW105111608A priority patent/TW201710256A/zh
Priority to US15/567,549 priority patent/US10369139B2/en
Priority to CA2979157A priority patent/CA2979157A1/en
Priority to EP16718883.8A priority patent/EP3286189B1/en
Priority to BR112017020046A priority patent/BR112017020046A2/pt
Priority to CN201680023291.3A priority patent/CN107531701A/zh
Priority to AU2016252236A priority patent/AU2016252236A1/en
Priority to HK18109399.8A priority patent/HK1249907A1/zh
Priority to JP2017550912A priority patent/JP2018513139A/ja
Priority to KR1020177032023A priority patent/KR20170139046A/ko
Priority to MX2017013048A priority patent/MX2017013048A/es
Priority to SG11201707868YA priority patent/SG11201707868YA/en
Priority to EA201792122A priority patent/EA033064B1/ru
Priority to PCT/GB2016/051120 priority patent/WO2016170352A1/en
Priority to IL254154A priority patent/IL254154A0/en
Priority to JP2021012440A priority patent/JP2021073259A/ja
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/10—Inorganic compounds or compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
GBGB1507036.0A 2015-04-24 2015-04-24 Crystalline enzyme inhibitor compound Ceased GB201507036D0 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
GBGB1507036.0A GB201507036D0 (en) 2015-04-24 2015-04-24 Crystalline enzyme inhibitor compound
TW105111608A TW201710256A (zh) 2015-04-24 2016-04-14 新穎醫藥鹽形態及結晶形態
PCT/GB2016/051120 WO2016170352A1 (en) 2015-04-24 2016-04-22 Crystalline compound as semicarbazide-sensitive amine oxidase (ssao) enzyme inhibitor
HK18109399.8A HK1249907A1 (zh) 2015-04-24 2016-04-22 作为氨基脲敏感性胺氧化酶(ssao)酶抑制剂的结晶化合物
JP2017550912A JP2018513139A (ja) 2015-04-24 2016-04-22 セミカルバジド感受性アミンオキシダーゼ酵素阻害剤としての結晶性化合物
EP16718883.8A EP3286189B1 (en) 2015-04-24 2016-04-22 Crystalline mesylate salt as semicarbazide-sensitive amine oxidase (ssao) enzyme inhibitor
BR112017020046A BR112017020046A2 (pt) 2015-04-24 2016-04-22 composto cristalino como inibidor de enzima amina oxidase sensível à semicarbazida (ssao)
CN201680023291.3A CN107531701A (zh) 2015-04-24 2016-04-22 作为氨基脲敏感性胺氧化酶(ssao)酶抑制剂的结晶化合物
AU2016252236A AU2016252236A1 (en) 2015-04-24 2016-04-22 Crystalline compound as semicarbazide-sensitive amine oxidase (SSAO) enzyme inhibitor
US15/567,549 US10369139B2 (en) 2015-04-24 2016-04-22 Crystalline compound as semicarbazide-sensitive amine oxidase (SSAO) enzyme inhibitor
CA2979157A CA2979157A1 (en) 2015-04-24 2016-04-22 Crystalline compound as semicarbazide-sensitive amine oxidase (ssao) enzyme inhibitor
KR1020177032023A KR20170139046A (ko) 2015-04-24 2016-04-22 세미카바자이드-민감성 아민 산화효소(ssao) 효소 억제제로서의 결정질 화합물
MX2017013048A MX2017013048A (es) 2015-04-24 2016-04-22 Compuesto cristalino como inhibidor de la enzima amina oxidasa sensible a semicarbazida (ssao).
SG11201707868YA SG11201707868YA (en) 2015-04-24 2016-04-22 Crystalline compound as semicarbazide-sensitive amine oxidase (ssao) enzyme inhibitor
EA201792122A EA033064B1 (ru) 2015-04-24 2016-04-22 Кристаллическое соединение как ингибитор фермента семикарбазидчувствительной аминоксидазы (ssao)
IL254154A IL254154A0 (en) 2015-04-24 2017-08-24 A crystalline compound as an inhibitor of the enzyme semicarbazide-sensitive amine oxidase (ssao)
JP2021012440A JP2021073259A (ja) 2015-04-24 2021-01-28 セミカルバジド感受性アミンオキシダーゼ酵素阻害剤としての結晶性化合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1507036.0A GB201507036D0 (en) 2015-04-24 2015-04-24 Crystalline enzyme inhibitor compound

Publications (1)

Publication Number Publication Date
GB201507036D0 true GB201507036D0 (en) 2015-06-10

Family

ID=53488634

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1507036.0A Ceased GB201507036D0 (en) 2015-04-24 2015-04-24 Crystalline enzyme inhibitor compound

Country Status (15)

Country Link
US (1) US10369139B2 (enExample)
EP (1) EP3286189B1 (enExample)
JP (2) JP2018513139A (enExample)
KR (1) KR20170139046A (enExample)
CN (1) CN107531701A (enExample)
AU (1) AU2016252236A1 (enExample)
BR (1) BR112017020046A2 (enExample)
CA (1) CA2979157A1 (enExample)
EA (1) EA033064B1 (enExample)
GB (1) GB201507036D0 (enExample)
HK (1) HK1249907A1 (enExample)
IL (1) IL254154A0 (enExample)
MX (1) MX2017013048A (enExample)
SG (1) SG11201707868YA (enExample)
WO (1) WO2016170352A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201507048D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd Treatment of pain
GB201507031D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd New pharmaceutical salt forms
GB201618029D0 (en) 2016-10-25 2016-12-07 Proximagen Ltd New process

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141899A (en) 1976-01-07 1979-02-27 Societa' Farmaceutici Italia S.P.A. 4,5,6,7-Tetrahydroimidazo-[4,5-c]-pyridine derivatives
IT1098015B (it) 1978-08-07 1985-08-31 Farmaceutici Italia Nuovi 4,5,6,7,-tetraidroimidazo-aperta par.quadrata 4,5-c chiusa par.quadrata-piridin-derivati
US6908926B1 (en) 1999-04-16 2005-06-21 Novo Nordisk A/S Substituted imidazoles, their preparation and use
SE0004101D0 (sv) 2000-11-09 2000-11-09 Pharmacia Ab New use
AU2002214505A1 (en) 2000-11-09 2002-05-21 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-(4,5-c)pyridine derivatives
US20070066646A1 (en) 2005-08-02 2007-03-22 Genmedica Therapeutics Sl Compounds for Inhibiting Copper-Containing Amine Oxidases and Uses Thereof
EP3461499A1 (en) 2006-06-07 2019-04-03 The Board of Trustees of The Leland Stanford Junior University Anti-leukocyte recruitment therapy for the treatment of recurrence of epileptic seizures
CN102232073B (zh) * 2008-09-16 2014-10-29 普罗克西梅根有限公司 Ssao活性抑制剂
WO2014199171A1 (en) 2013-06-12 2014-12-18 Proximagen Limited New therapeutic uses of enzyme inhibitors
WO2015159112A1 (en) 2014-04-15 2015-10-22 Pécsi Tudományegyetem Semicarbazide-sensitive amine oxidase inhibitors for use as analgesics in traumatic neuropathy and neurogenic inflammation
GB201507048D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd Treatment of pain
GB201507031D0 (en) * 2015-04-24 2015-06-10 Proximagen Ltd New pharmaceutical salt forms

Also Published As

Publication number Publication date
CA2979157A1 (en) 2016-10-27
JP2021073259A (ja) 2021-05-13
US10369139B2 (en) 2019-08-06
EP3286189A1 (en) 2018-02-28
JP2018513139A (ja) 2018-05-24
MX2017013048A (es) 2017-12-08
IL254154A0 (en) 2017-10-31
EP3286189B1 (en) 2021-05-26
KR20170139046A (ko) 2017-12-18
CN107531701A (zh) 2018-01-02
EA033064B1 (ru) 2019-08-30
WO2016170352A1 (en) 2016-10-27
EA201792122A1 (ru) 2018-03-30
BR112017020046A2 (pt) 2018-06-05
AU2016252236A1 (en) 2017-10-05
US20180085357A1 (en) 2018-03-29
HK1249907A1 (zh) 2018-11-16
SG11201707868YA (en) 2017-11-29

Similar Documents

Publication Publication Date Title
PL3371190T3 (pl) Związki heterocykliczne jako inhibitory pi3k-gamma
GB201421083D0 (en) Enzyme inhibitors
GB201416446D0 (en) New enzyme inhibitor compounds
IL251932B (en) Benzylpropargyl ether as nitrification inhibitors
ZA201708244B (en) Thioether compounds as nitrification inhibitors
GB201513481D0 (en) Inhibitor compounds
EP3303324A4 (en) Novel corrosion inhibitors
IL254974B (en) Crystalline compound of fgfr4 inhibitor and uses thereof
EP3240767A4 (en) Microencapsulated nitrification inhibitor compositions
GB201403536D0 (en) Inhibitor compounds
PL3552017T3 (pl) Związki użyteczne jako inhibitory RIPK1
GB201505658D0 (en) Inhibitor compounds
EP3137437A4 (en) Microencapsulated nitrification inhibitor composition
SI3380554T2 (sl) Kristalne oblike per-kloro-gama-ciklodekstrinov
SG10201911417PA (en) Crystalline compounds
EP3250562A4 (en) Crystalline forms of c21h22ci2n4o2
EP3258929A4 (en) FACTOR IXa INHIBITORS
IL253479A0 (en) Crystalline forms of efinconazole
GB201507036D0 (en) Crystalline enzyme inhibitor compound
PL3350179T3 (pl) Krystaliczne postacie
IL247025A0 (en) enzyme inhibitors
HK40102359A (zh) 结晶化合物
HK40099983A (zh) 结晶化合物
HK40101405A (zh) C21H22Cl2N4O2的晶型
HK40000072A (en) Metalloenzyme inhibitor compounds

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)