GB201403093D0 - Therapeutic compounds and their use - Google Patents
Therapeutic compounds and their useInfo
- Publication number
- GB201403093D0 GB201403093D0 GB201403093A GB201403093A GB201403093D0 GB 201403093 D0 GB201403093 D0 GB 201403093D0 GB 201403093 A GB201403093 A GB 201403093A GB 201403093 A GB201403093 A GB 201403093A GB 201403093 D0 GB201403093 D0 GB 201403093D0
- Authority
- GB
- United Kingdom
- Prior art keywords
- therapeutic compounds
- therapeutic
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403093A GB201403093D0 (en) | 2014-02-21 | 2014-02-21 | Therapeutic compounds and their use |
| LTEP15706282.9T LT3107914T (lt) | 2014-02-21 | 2015-02-20 | Pirazolo[1,5-a]pirimidin-5,7-diamino junginiai kaip cdk inhibitoriai ir jų terapinis panaudojimas |
| PCT/GB2015/050494 WO2015124941A1 (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use |
| PL15706282T PL3107914T3 (pl) | 2014-02-21 | 2015-02-20 | Związki pirazolo[1,5-a]pirymidyno-5,7-diaminowe jako inhibitory CDK i ich zastosowanie terapeutyczne |
| PT15706282T PT3107914T (pt) | 2014-02-21 | 2015-02-20 | Compostos de pirazolo[1,5-a]pirimidina-5,7-diamina como inibidores de cdk e utilização terapêutica dos mesmos |
| AU2015220560A AU2015220560B2 (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use |
| MEP-2019-119A ME03427B (me) | 2014-02-21 | 2015-02-20 | Pirazolo[1,5-a]pirimidin-5,7-diamin jedinjenja kao cdk inhibitori i njihova terapeutska primjena |
| EP15706282.9A EP3107914B8 (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use |
| JP2016553387A JP6498212B2 (ja) | 2014-02-21 | 2015-02-20 | Cdk阻害剤としてのピラゾロ[1,5‐a]ピリミジン‐5,7‐ジアミン化合物及びその治療用途 |
| TR2019/05647T TR201905647T4 (tr) | 2014-02-21 | 2015-02-20 | Cdk inhibitörleri olarak pirazolo[1,5-a]pirimidin-5,7-diamin bileşikleri ve onların terapötik kullanımı. |
| US15/117,982 US9932344B2 (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-A]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use |
| HRP20190685TT HRP20190685T1 (hr) | 2014-02-21 | 2015-02-20 | Spojevi pirazolo[1,5-a]pirimidin-5,7-diamina kao inhibitori za cdk i njihove terapeutske uporabe |
| SM20190266T SMT201900266T1 (it) | 2014-02-21 | 2015-02-20 | Composti di pirazolo[1,5-a]piramidin-5,7-diammina come inibitori di cdk e loro uso terapeutico |
| RS20190487A RS58704B1 (sr) | 2014-02-21 | 2015-02-20 | Pirazolo[1,5-a]pirimidin-5,7-diamin jedinjenja kao cdk inhibitori i njihova terapeutska primena |
| BR112016018633-8A BR112016018633B1 (pt) | 2014-02-21 | 2015-02-20 | Pirazolopirimidina-5,7-diaminas como inibidores de cdk, seus usos, composição farmacêutica e seu método de preparação, e método in vitro para inibir a função de quinase dependente de ciclina em uma célula |
| ES15706282T ES2721268T3 (es) | 2014-02-21 | 2015-02-20 | Compuestos de pirazolo[1,5-a]pirimidina-5,7-diamina como inhibidores de CDK y su uso terapéutico |
| CA2939786A CA2939786C (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use |
| CN201580011502.7A CN106103445B (zh) | 2014-02-21 | 2015-02-20 | 作为cdk抑制剂的吡唑并[1,5-a]嘧啶-5,7-二胺化合物和它们的治疗用途 |
| HUE15706282A HUE043122T2 (hu) | 2014-02-21 | 2015-02-20 | Pirazolo[1,5-a]pirimidin-5,7-diamin vegyületek mint CDK inhibitorok és terápiás alkalmazásuk |
| SI201530714T SI3107914T1 (sl) | 2014-02-21 | 2015-02-20 | Pirazolo(1,5-A)pirimidin-5,7-diaminske spojine kot inhibitorji CDK in njihova terapevtska uporaba |
| NZ724323A NZ724323A (en) | 2014-02-21 | 2015-02-20 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as cdk inhibitors and their therapeutic use |
| DK15706282.9T DK3107914T3 (en) | 2014-02-21 | 2015-02-20 | PYRAZOLO [1,5-A] PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THERAPEUTIC APPLICATION THEREOF |
| US15/941,063 US10414772B2 (en) | 2014-02-21 | 2018-03-30 | Pyrazolo[1,5-A]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use |
| CY20191100425T CY1121588T1 (el) | 2014-02-21 | 2019-04-17 | Ενωσεις πυραζολο[1,5-α]πυριμιδινο-5,7-διαμινης ως αναστολεις cdk και θεραπευτικη χρηση αυτων |
| US16/559,735 US10927119B2 (en) | 2014-02-21 | 2019-09-04 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use |
| US17/175,780 US11566029B2 (en) | 2014-02-21 | 2021-02-15 | Pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201403093A GB201403093D0 (en) | 2014-02-21 | 2014-02-21 | Therapeutic compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB201403093D0 true GB201403093D0 (en) | 2014-04-09 |
Family
ID=50482596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB201403093A Ceased GB201403093D0 (en) | 2014-02-21 | 2014-02-21 | Therapeutic compounds and their use |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US9932344B2 (OSRAM) |
| EP (1) | EP3107914B8 (OSRAM) |
| JP (1) | JP6498212B2 (OSRAM) |
| CN (1) | CN106103445B (OSRAM) |
| AU (1) | AU2015220560B2 (OSRAM) |
| BR (1) | BR112016018633B1 (OSRAM) |
| CA (1) | CA2939786C (OSRAM) |
| CY (1) | CY1121588T1 (OSRAM) |
| DK (1) | DK3107914T3 (OSRAM) |
| ES (1) | ES2721268T3 (OSRAM) |
| GB (1) | GB201403093D0 (OSRAM) |
| HR (1) | HRP20190685T1 (OSRAM) |
| HU (1) | HUE043122T2 (OSRAM) |
| LT (1) | LT3107914T (OSRAM) |
| ME (1) | ME03427B (OSRAM) |
| NZ (1) | NZ724323A (OSRAM) |
| PL (1) | PL3107914T3 (OSRAM) |
| PT (1) | PT3107914T (OSRAM) |
| RS (1) | RS58704B1 (OSRAM) |
| SI (1) | SI3107914T1 (OSRAM) |
| SM (1) | SMT201900266T1 (OSRAM) |
| TR (1) | TR201905647T4 (OSRAM) |
| WO (1) | WO2015124941A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| AU2015337607B2 (en) | 2014-10-31 | 2020-04-09 | Ube Corporation | Substituted dihydropyrrolopyrazole compound |
| AU2015367531B2 (en) | 2014-12-17 | 2020-04-30 | King's College London | Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RARbeta) agonists |
| WO2016130920A2 (en) * | 2015-02-13 | 2016-08-18 | Dana-Farber Cancer Institute, Inc. | Lrrk2 inhibitors and methods of making and using the same |
| JP6787314B2 (ja) | 2015-06-15 | 2020-11-18 | 宇部興産株式会社 | 置換ジヒドロピロロピラゾール誘導体 |
| US20200123499A1 (en) | 2015-12-02 | 2020-04-23 | Massachusetts Institute Of Technology | Method for efficient generation of neurons from non-neuronal cells |
| AU2017319500C1 (en) | 2016-08-31 | 2022-10-20 | Les Laboratoires Servier | Inhibitors of cellular metabolic processes |
| US11046698B2 (en) | 2017-07-28 | 2021-06-29 | Nimbus Lakshmi, Inc. | TYK2 inhibitors and uses thereof |
| AU2018312836B2 (en) * | 2017-08-07 | 2022-12-08 | Joint Stock Company "Biocad" | Novel heterocyclic compounds as CDK8/19 inhibitors |
| US20200197392A1 (en) * | 2017-08-15 | 2020-06-25 | The Brigham & Women's Hospital, Inc. | Compositions and methods for treating tuberous sclerosis complex |
| GB201715194D0 (en) * | 2017-09-20 | 2017-11-01 | Carrick Therapeutics Ltd | Compounds and their therapeutic use |
| TWI703149B (zh) * | 2017-11-16 | 2020-09-01 | 美商美國禮來大藥廠 | 用於抑制cdk7之化合物 |
| CN112313235A (zh) * | 2018-04-11 | 2021-02-02 | 奎利恩特有限公司 | 作为周期蛋白依赖性激酶的选择性抑制剂的吡唑并-三嗪和/或吡唑并-嘧啶衍生物 |
| WO2019213403A1 (en) | 2018-05-02 | 2019-11-07 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
| AU2019291935A1 (en) | 2018-06-29 | 2021-02-04 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
| AU2019370200B2 (en) | 2018-10-30 | 2024-12-19 | Kronos Bio, Inc. | Compounds, compositions, and methods for modulating CDK9 activity |
| WO2020100944A1 (ja) | 2018-11-14 | 2020-05-22 | 宇部興産株式会社 | ジヒドロピロロピラゾール誘導体 |
| CN109860354B (zh) * | 2018-12-28 | 2020-05-19 | 南京邮电大学 | 同质集成红外光子芯片及其制备方法 |
| US20220144841A1 (en) * | 2019-03-13 | 2022-05-12 | The Translational Genomics Research Institute | Trisubstituted pyrazolo [1,5-a] pyrimidine compounds as cdk7 inhibitors |
| AU2020311297A1 (en) * | 2019-07-10 | 2022-02-03 | Aucentra Therapeutics Pty Ltd | DERIVATIVES OF 4-(IMIDAZO[l,2-a]PYRIDIN-3-YL)-N-(PYRIDINYL)PYRIMIDIN- 2-AMINE AS THERAPEUTIC AGENTS |
| WO2021087138A1 (en) * | 2019-10-29 | 2021-05-06 | Syros Pharmaceuticals, Inc. | Methods of treating cancer in biomarker-identified patients with inhibitors of cyclin-dependent kinase 7 (cdk7) |
| GB201918541D0 (en) * | 2019-12-16 | 2020-01-29 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| EP4114528A1 (en) * | 2020-03-06 | 2023-01-11 | Bayer Aktiengesellschaft | Imidazotriazines acting on cancer via inhibition of cdk12 |
| US20230158159A1 (en) * | 2020-04-24 | 2023-05-25 | Massachusetts Institute Of Technology | Chimeric degraders of cyclin-dependent kinase 9 and uses thereof |
| JP7657943B2 (ja) * | 2021-01-22 | 2025-04-07 | 上海海雁医薬科技有限公司 | 置換ピラゾロ[1,5-a]ピリミジン-7-アミン誘導体、その組成物及び医薬上の使用 |
| AR125798A1 (es) | 2021-05-07 | 2023-08-16 | Kymera Therapeutics Inc | Degradadores cdk2 y usos de los mismos |
| GB202108572D0 (en) * | 2021-06-16 | 2021-07-28 | Carrick Therapeutics Ltd | Therapeutic compounds and their use |
| WO2023001061A1 (en) * | 2021-07-17 | 2023-01-26 | Jingrui Biopharma Co., Ltd. | Cdk7 selective inhibitors as anticancer agents |
| WO2023096922A1 (en) * | 2021-11-24 | 2023-06-01 | Kronos Bio, Inc. | Polymorphic and salt forms of (ls,3s)-n1-(5-(pentan-3- yl)pyrazolo[l,5-a]pyrimidin-7-yl)cyclopentane-l,3-diamine |
| WO2024102447A1 (en) * | 2022-11-10 | 2024-05-16 | Emory University | Uses of hydroimidazopyridopyrimidinone derivatives for managing aneurysms or other vascular conditions or diseases |
| WO2024174949A1 (zh) * | 2023-02-20 | 2024-08-29 | 江苏正大丰海制药有限公司 | 作为cdk7激酶抑制剂的杂芳环化合物及其制备和应用 |
| CN120712267A (zh) * | 2023-02-21 | 2025-09-26 | 杭州德睿智药科技有限公司 | 作为CDKs抑制剂的新型并杂环类新化合物及其应用 |
| TW202500147A (zh) | 2023-06-27 | 2025-01-01 | 美商亞文納營運公司 | 雌激素受體降解劑與cdk7抑制劑之組合 |
| WO2025057087A1 (en) | 2023-09-11 | 2025-03-20 | Assia Chemical Industries Ltd. | Solid state forms of samuraciclib |
| WO2025208097A1 (en) * | 2024-03-29 | 2025-10-02 | The Translational Genomics Research Institute | Cdk7 inhibitors and methods of use thereof |
| WO2025208104A1 (en) * | 2024-03-29 | 2025-10-02 | The Translational Genomics Research Institute | Cdk7 inhibitors and methods of use thereof |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4794793B2 (ja) | 1999-12-28 | 2011-10-19 | ファーマコペイア, インコーポレイテッド | N−ヘテロ環TNF−α発現阻害剤 |
| EP1537116B1 (en) | 2002-09-04 | 2010-06-02 | Schering Corporation | Pyrazolopyrimidines suitable for the treatment of cancer diseases |
| AU2004210149A1 (en) | 2003-01-31 | 2004-08-19 | Merck & Co., Inc. | 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes |
| MXPA05008955A (es) | 2003-02-28 | 2006-02-22 | Teijin Pharma Ltd | Derivados de pirazolo [1,5-a] pirimidina. |
| EP1608652A1 (en) * | 2003-03-31 | 2005-12-28 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JO2478B1 (en) | 2003-06-19 | 2009-01-20 | جانسين فارماسوتيكا ان. في. | (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists |
| TWI421078B (zh) * | 2005-10-06 | 2014-01-01 | Merck Sharp & Dohme | 關卡激酶抑制劑及其用途 |
| EP2170073A4 (en) * | 2007-06-05 | 2011-07-27 | Univ Emory | SELECTIVE INHIBITORS FOR CYCLINE-RELATED KINASES |
| US8575177B2 (en) * | 2009-12-04 | 2013-11-05 | Senhwa Biosciences, Inc. | Pyrazolopyrimidines and related heterocycles as CK2 inhibitors |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| EP3409278B8 (en) * | 2011-07-21 | 2020-11-04 | Sumitomo Dainippon Pharma Oncology, Inc. | Heterocyclic protein kinase inhibitors |
| EP2634190A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors |
| EP2634189A1 (en) | 2012-03-01 | 2013-09-04 | Lead Discovery Center GmbH | Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhibitors |
| GB201403093D0 (en) | 2014-02-21 | 2014-04-09 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
-
2014
- 2014-02-21 GB GB201403093A patent/GB201403093D0/en not_active Ceased
-
2015
- 2015-02-20 HU HUE15706282A patent/HUE043122T2/hu unknown
- 2015-02-20 TR TR2019/05647T patent/TR201905647T4/tr unknown
- 2015-02-20 BR BR112016018633-8A patent/BR112016018633B1/pt active IP Right Grant
- 2015-02-20 ME MEP-2019-119A patent/ME03427B/me unknown
- 2015-02-20 ES ES15706282T patent/ES2721268T3/es active Active
- 2015-02-20 SI SI201530714T patent/SI3107914T1/sl unknown
- 2015-02-20 JP JP2016553387A patent/JP6498212B2/ja active Active
- 2015-02-20 CA CA2939786A patent/CA2939786C/en active Active
- 2015-02-20 LT LTEP15706282.9T patent/LT3107914T/lt unknown
- 2015-02-20 US US15/117,982 patent/US9932344B2/en active Active
- 2015-02-20 CN CN201580011502.7A patent/CN106103445B/zh active Active
- 2015-02-20 HR HRP20190685TT patent/HRP20190685T1/hr unknown
- 2015-02-20 RS RS20190487A patent/RS58704B1/sr unknown
- 2015-02-20 NZ NZ724323A patent/NZ724323A/en unknown
- 2015-02-20 PT PT15706282T patent/PT3107914T/pt unknown
- 2015-02-20 DK DK15706282.9T patent/DK3107914T3/en active
- 2015-02-20 AU AU2015220560A patent/AU2015220560B2/en active Active
- 2015-02-20 WO PCT/GB2015/050494 patent/WO2015124941A1/en not_active Ceased
- 2015-02-20 EP EP15706282.9A patent/EP3107914B8/en active Active
- 2015-02-20 PL PL15706282T patent/PL3107914T3/pl unknown
- 2015-02-20 SM SM20190266T patent/SMT201900266T1/it unknown
-
2018
- 2018-03-30 US US15/941,063 patent/US10414772B2/en active Active
-
2019
- 2019-04-17 CY CY20191100425T patent/CY1121588T1/el unknown
- 2019-09-04 US US16/559,735 patent/US10927119B2/en active Active
-
2021
- 2021-02-15 US US17/175,780 patent/US11566029B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AT | Applications terminated before publication under section 16(1) |