GB201020738D0 - Antibodies - Google Patents

Antibodies

Info

Publication number
GB201020738D0
GB201020738D0 GB201020738A GB201020738A GB201020738D0 GB 201020738 D0 GB201020738 D0 GB 201020738D0 GB 201020738 A GB201020738 A GB 201020738A GB 201020738 A GB201020738 A GB 201020738A GB 201020738 D0 GB201020738 D0 GB 201020738D0
Authority
GB
United Kingdom
Prior art keywords
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201020738A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Affitech Research AS
Original Assignee
Affitech Research AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affitech Research AS filed Critical Affitech Research AS
Priority to GB201020738A priority Critical patent/GB201020738D0/en
Publication of GB201020738D0 publication Critical patent/GB201020738D0/en
Priority to BR112013014235A priority patent/BR112013014235A2/pt
Priority to AU2011340264A priority patent/AU2011340264B2/en
Priority to SG2013037577A priority patent/SG190299A1/en
Priority to NZ612175A priority patent/NZ612175A/en
Priority to MX2013006167A priority patent/MX2013006167A/es
Priority to PCT/GB2011/052421 priority patent/WO2012076883A1/en
Priority to CN201180066005.9A priority patent/CN103328513B/zh
Priority to KR20137017710A priority patent/KR20130132903A/ko
Priority to EA201390813A priority patent/EA201390813A1/ru
Priority to CA2818313A priority patent/CA2818313A1/en
Priority to JP2013542608A priority patent/JP6215707B2/ja
Priority to EP11794570.9A priority patent/EP2649097A1/en
Priority to US13/313,541 priority patent/US8895007B2/en
Priority to IL226427A priority patent/IL226427A0/en
Priority to CO13150835A priority patent/CO6761356A2/es
Priority to ZA2013/04723A priority patent/ZA201304723B/en
Priority to US14/515,892 priority patent/US9458238B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7158—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for chemokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
GB201020738A 2010-12-07 2010-12-07 Antibodies Ceased GB201020738D0 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB201020738A GB201020738D0 (en) 2010-12-07 2010-12-07 Antibodies
US13/313,541 US8895007B2 (en) 2010-12-07 2011-12-07 Antibodies which bind to the human CC chemokine receptor 4 and uses thereof
KR20137017710A KR20130132903A (ko) 2010-12-07 2011-12-07 항-ccr4 항체들 및 이의 용도들
CA2818313A CA2818313A1 (en) 2010-12-07 2011-12-07 Anti ccr4 antibodies and uses thereof
SG2013037577A SG190299A1 (en) 2010-12-07 2011-12-07 Anti ccr4 antibodies and uses thereof
NZ612175A NZ612175A (en) 2010-12-07 2011-12-07 Anti ccr4 antibodies and uses thereof
MX2013006167A MX2013006167A (es) 2010-12-07 2011-12-07 Anticuerpos anti receptor 4 de quimiocina cc (ccr4) y usos de los mismos.
PCT/GB2011/052421 WO2012076883A1 (en) 2010-12-07 2011-12-07 Anti ccr4 antibodies and uses thereof
CN201180066005.9A CN103328513B (zh) 2010-12-07 2011-12-07 抗ccr4抗体及其应用
BR112013014235A BR112013014235A2 (pt) 2010-12-07 2011-12-07 anticorpos anti-ccr4 e usos dos mesmos
EA201390813A EA201390813A1 (ru) 2010-12-07 2011-12-07 Антитела и их применение
AU2011340264A AU2011340264B2 (en) 2010-12-07 2011-12-07 Anti CCR4 antibodies and uses thereof
JP2013542608A JP6215707B2 (ja) 2010-12-07 2011-12-07 抗ccr4抗体およびその使用
EP11794570.9A EP2649097A1 (en) 2010-12-07 2011-12-07 Anti ccr4 antibodies and uses thereof
IL226427A IL226427A0 (en) 2010-12-07 2013-05-19 Anti ccr4 antibodies and uses thereof
CO13150835A CO6761356A2 (es) 2010-12-07 2013-06-25 Anticuerpos anti receptr 4 de quimiricina cc (ccr4) y usos de los mismos
ZA2013/04723A ZA201304723B (en) 2010-12-07 2013-06-25 Anti ccr4 antibodies and uses thereof
US14/515,892 US9458238B2 (en) 2010-12-07 2014-10-16 Nucleic acid molecules encoding antibodies which bind CCR4 and uses thereof

Applications Claiming Priority (1)

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Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2512857A (en) 2013-04-09 2014-10-15 Cancer Res Technology Cancer biomarker
US20170121419A1 (en) * 2014-06-12 2017-05-04 The General Hospital Corporation Anti-human Chemokine (C-C motif) Receptor 4 Immunotoxins
US10973920B2 (en) 2014-06-30 2021-04-13 Glykos Finland Oy Saccharide derivative of a toxic payload and antibody conjugates thereof
CA2962949C (en) * 2014-10-06 2024-03-05 Dana-Farber Cancer Institute, Inc. Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof
PE20180774A1 (es) 2015-07-23 2018-05-07 Boehringer Ingelheim Int Compuesto que se dirige a il-23a y al factor de activacion de linfocitos b (baff) y usos de estos
KR102379464B1 (ko) 2016-06-20 2022-03-29 키맵 리미티드 항-pd-l1 항체
EP3574098A4 (en) * 2017-01-30 2020-11-04 Ofer Nussbaum APPROPRIATE CHEMICAL ENTITIES FOR THERAPY
JP6811480B2 (ja) * 2017-02-28 2021-01-13 日本全薬工業株式会社 イヌ皮膚t細胞リンパ腫細胞株
US20210163607A1 (en) * 2017-05-19 2021-06-03 Nippon Zenyaku Kogyo Co., Ltd. Method for suppressing regulatory t cell infiltration by ccr4 inhibition and method for treating canine neoplastic disease
WO2019032628A1 (en) 2017-08-07 2019-02-14 The Regents Of The University Of California GENERATING PLATFORM FOR SAFE CELLULAR THERAPEUTIC AGENTS
CN108250290B (zh) * 2018-02-23 2024-03-12 上海捌加壹医药科技有限公司 Ccr4的n端重组蛋白及其用途
EP4549555A3 (en) * 2019-05-24 2025-07-30 City of Hope Ccr4 targeted chimeric antigen receptor modified t cells for treatment of ccr4 positive malignancies
CN111135310B (zh) * 2019-12-24 2021-05-07 江苏省人民医院(南京医科大学第一附属医院) 一种定制化t细胞表位疫苗的双靶向纳米药、其制备方法及应用
JP6960642B2 (ja) * 2020-04-16 2021-11-05 国立研究開発法人国立国際医療研究センター 呼吸器感染症の重症化の予測を補助する方法、バイオマーカーの測定値をモニタリングする方法、これらの方法に用いられる試薬キット、呼吸器感染症の重症化の予測を補助する装置およびコンピュータプログラム
CN111704668B (zh) * 2020-06-27 2021-03-30 天津金域医学检验实验室有限公司 抗ccr4抗体及其在治疗癌症中的应用
KR102900282B1 (ko) * 2022-04-08 2025-12-22 국민대학교 산학협력단 케모카인 수용체 cxcr4에 대한 고 친화성 항체
CN117187180B (zh) * 2023-11-03 2024-01-26 四川大学 一种Th17细胞及其培养方法和应用及其诱导液
CN122459678A (zh) 2023-12-29 2026-07-24 百时美施贵宝公司 KRAS抑制剂与Treg耗竭剂的组合疗法
CN119775429B (zh) * 2024-12-26 2026-08-07 南开大学 一种抗人her2/ccr4的双特异性抗体及其应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437213A1 (fr) 1978-09-28 1980-04-25 Cm Ind Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
WO1990010457A1 (en) 1989-03-14 1990-09-20 New York University Method of treating hiv infections using immunotoxins
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
US5776427A (en) 1992-03-05 1998-07-07 Board Of Regents, The University Of Texas System Methods for targeting the vasculature of solid tumors
EP1306095A3 (en) 1992-03-05 2003-06-25 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
US5965132A (en) 1992-03-05 1999-10-12 Board Of Regents, The University Of Texas System Methods and compositions for targeting the vasculature of solid tumors
AU2004201168A1 (en) 1999-01-15 2004-04-22 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
US6245332B1 (en) * 1999-01-15 2001-06-12 The Board Of Trustees Of The Leland Stanford Junior University Modulation of systemic memory T cell trafficking
US6488930B1 (en) * 1999-01-15 2002-12-03 Millennium Pharmaceuticals, Inc. Anti-CCR4 antibodies and methods of use therefor
EP1050307A1 (en) * 1999-05-06 2000-11-08 Applied Research Systems ARS Holding N.V. CCR4 antagonists in sepsis
SI1270595T1 (sl) 2000-03-03 2008-12-31 Kyowa Hakko Kogyo Kk Protitelo proti CCR4 in njegov fragment
MXPA03007681A (es) 2001-02-28 2004-11-12 Protein Design Labs Inc Receptores para quimiocinas y enfermedades.
CN100430420C (zh) 2001-08-31 2008-11-05 协和发酵工业株式会社 人cdr-移植抗体及其抗体片段
AU2004279739A1 (en) * 2003-10-08 2005-04-21 Kyowa Hakko Kirin Co., Ltd. Composition of antibody capable of specifically binding CCR4
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
WO2009086514A1 (en) * 2007-12-28 2009-07-09 Dana-Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
GB0909906D0 (en) * 2009-06-09 2009-07-22 Affitech As Antibodies
US8802442B2 (en) 2011-11-30 2014-08-12 Eric B. Wheeldon Apparatus and method for the remote sensing of blood in human feces and urine

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JP6215707B2 (ja) 2017-10-18
US8895007B2 (en) 2014-11-25
CN103328513B (zh) 2016-04-27
CO6761356A2 (es) 2013-09-30
US20120164161A1 (en) 2012-06-28
US9458238B2 (en) 2016-10-04
KR20130132903A (ko) 2013-12-05
ZA201304723B (en) 2014-02-26
AU2011340264B2 (en) 2016-05-26
BR112013014235A2 (pt) 2016-09-27
MX2013006167A (es) 2013-09-06
CN103328513A (zh) 2013-09-25
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IL226427A0 (en) 2013-07-31
US20150104831A1 (en) 2015-04-16
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EP2649097A1 (en) 2013-10-16
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JP2014513519A (ja) 2014-06-05
CA2818313A1 (en) 2012-06-14

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