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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority to GB7847287ApriorityCriticalpatent/GB2009734B/en
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Publication of GB2009734BpublicationCriticalpatent/GB2009734B/en
C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
C07D501/02—Preparation
C07D501/12—Separation; Purification
Abstract
A process for the recovery of cephalosporin C comprises: (a) contacting a fermentation broth containing cephalosporin C with an anion exchange resin which is either a weak-base resin in the weak acid salt form or free base form or a strong- base resin in the weak acid salt form, to obtain a weakly acidic percolate containing said cephalosporin C from which anions of strong acids present in said broth have been removed; (b) contacting the resulting solution with a strong cation exchange resin in the acid form, whereby cations in said resulting solution are replaced by protons and said cephalosporin C remains in the substantially deionised percolate; and (c) adsorbing cephalosporin C from said percolate onto a weak-base anion exchange resin. c
GB7847287A1977-12-061978-12-05Processing of cephalosporin
ExpiredGB2009734B
(en)
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