GB2008767A - Immunochemical Testing Using Tagged Reagents - Google Patents

Immunochemical Testing Using Tagged Reagents

Info

Publication number
GB2008767A
GB2008767A GB7842707A GB7842707A GB2008767A GB 2008767 A GB2008767 A GB 2008767A GB 7842707 A GB7842707 A GB 7842707A GB 7842707 A GB7842707 A GB 7842707A GB 2008767 A GB2008767 A GB 2008767A
Authority
GB
United Kingdom
Prior art keywords
reagent
immune
analyte
coated
reactance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7842707A
Other versions
GB2008767B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/942,261 external-priority patent/US4219335A/en
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of GB2008767A publication Critical patent/GB2008767A/en
Application granted granted Critical
Publication of GB2008767B publication Critical patent/GB2008767B/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Abstract

The invention provides a method for determining the presence of an analyte 11 in a body fluid consisting essentially of: (a) contacting a surface 2 with said fluid, said surface 2 being coated with receptor reagent 10 specifically reactive with said analyte 11; to form a complex 12; (b) contacting the coated surface 2 with immune reagent 13 comprising immune compound 14 specifically reactive with the receptor reagent or, as illustrated, specifically reactive with a complex 12 of the analyte and receptor reagent, said immune compound 14 being coated on reactance tags 15 which are particles capable of affecting electrical reactance; (c) removing unreacted immune reagent 13 from the surface 2; and (d) measuring the electric reactance of the surface, due to those particles 15 which remain bonded 16 to the surface 2. The invention also provides an automated analytical system suitable for use in the said method. Dielectric, conductive or magnetic particles may be used. Ferromagnetic particles are preferred, to be used with apparatus which magnetises the surface 2 in the manner of a tape-recorder. <IMAGE>
GB7842707A 1977-11-03 1978-11-01 Immunochemical testing using tagged reagents Expired GB2008767B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84821777A 1977-11-03 1977-11-03
US05/942,261 US4219335A (en) 1978-09-18 1978-09-18 Immunochemical testing using tagged reagents

Publications (2)

Publication Number Publication Date
GB2008767A true GB2008767A (en) 1979-06-06
GB2008767B GB2008767B (en) 1982-06-30

Family

ID=27126757

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7842707A Expired GB2008767B (en) 1977-11-03 1978-11-01 Immunochemical testing using tagged reagents

Country Status (16)

Country Link
JP (1) JPS5912139B2 (en)
AU (1) AU522995B2 (en)
CA (1) CA1122503A (en)
CH (1) CH638052A5 (en)
DE (1) DE2847282A1 (en)
DK (1) DK489678A (en)
FI (1) FI783346A (en)
FR (1) FR2408142A1 (en)
GB (1) GB2008767B (en)
IE (1) IE47482B1 (en)
IL (1) IL55856A (en)
IT (1) IT1101280B (en)
LU (1) LU80471A1 (en)
NL (1) NL7810910A (en)
NO (1) NO151099C (en)
SE (1) SE431257B (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2136130A (en) * 1983-02-28 1984-09-12 Theodore Henry Krueger Chemical Assay Systems
EP0177813A1 (en) * 1984-10-12 1986-04-16 Labsystems Oy Immunological assay method
US5137804A (en) * 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
GB2270976A (en) * 1992-09-18 1994-03-30 Marconi Gec Ltd Immunoassay/separation process using an auxiliary species on a support
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
WO2000014540A1 (en) * 1998-09-08 2000-03-16 Tibotec N.V. Method for the rapid screening of analytes
US6544480B1 (en) 1999-10-26 2003-04-08 Tibotec Bvba Device and related method for dispensing small volumes of liquid

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1220818A (en) * 1983-05-05 1987-04-21 Hugh A.O. Hill Assay techniques utilising specific binding agents
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
EP0139373A1 (en) * 1983-08-26 1985-05-02 The Regents Of The University Of California Multiple immunoassay system
JPS6055265A (en) * 1983-09-06 1985-03-30 Fujirebio Inc Measuring method of antigen and antibody by using magnetic particle
GB8331514D0 (en) * 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
AU596946B2 (en) * 1984-07-10 1990-05-24 F. Hoffmann-La Roche Ltd Methods of assay
JPH0823558B2 (en) * 1984-11-27 1996-03-06 オ−ジエニクス リミテツド Verification device
LU86239A1 (en) * 1986-01-02 1987-09-03 Sanders Probel Lab METHOD OF DETECTING REAGENT AGENTS AND MEANS FOR IMPLEMENTING THE SAME
US4794089A (en) * 1986-03-25 1988-12-27 Midwest Research Microscopy, Inc. Method for electronic detection of a binding reaction

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1479661A (en) * 1972-06-26 1977-07-13 Gen Electric Method and apparatus for detection and purification of proteins and antibodies
GB1500127A (en) * 1973-10-10 1978-02-08 Abbott Lab Reactive matrices
US4020151A (en) * 1976-02-17 1977-04-26 International Diagnostic Technology, Inc. Method for quantitation of antigens or antibodies on a solid surface
IL49685A (en) * 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
US4087248A (en) * 1976-07-26 1978-05-02 Miles Laughton E Multiple assay machine and method

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2136130A (en) * 1983-02-28 1984-09-12 Theodore Henry Krueger Chemical Assay Systems
EP0177813A1 (en) * 1984-10-12 1986-04-16 Labsystems Oy Immunological assay method
US5137804A (en) * 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
US5374524A (en) * 1988-05-10 1994-12-20 E. I. Du Pont De Nemours And Company Solution sandwich hybridization, capture and detection of amplified nucleic acids
US5391478A (en) * 1988-05-10 1995-02-21 E. I. Du Pont De Nemours And Company Assay device and immunoassay
GB2270976A (en) * 1992-09-18 1994-03-30 Marconi Gec Ltd Immunoassay/separation process using an auxiliary species on a support
WO2000014540A1 (en) * 1998-09-08 2000-03-16 Tibotec N.V. Method for the rapid screening of analytes
US6544480B1 (en) 1999-10-26 2003-04-08 Tibotec Bvba Device and related method for dispensing small volumes of liquid

Also Published As

Publication number Publication date
JPS5912139B2 (en) 1984-03-21
IT1101280B (en) 1985-09-28
IE47482B1 (en) 1984-04-04
CH638052A5 (en) 1983-08-31
AU522995B2 (en) 1982-07-08
SE431257B (en) 1984-01-23
IT7829378A0 (en) 1978-11-02
AU4128378A (en) 1979-05-17
CA1122503A (en) 1982-04-27
IE782168L (en) 1980-03-18
LU80471A1 (en) 1979-06-15
GB2008767B (en) 1982-06-30
FR2408142A1 (en) 1979-06-01
DE2847282A1 (en) 1979-05-10
NL7810910A (en) 1979-05-07
FI783346A (en) 1979-05-04
NO151099B (en) 1984-10-29
NO783691L (en) 1979-05-04
SE7810351L (en) 1979-05-04
JPS5491296A (en) 1979-07-19
IL55856A0 (en) 1979-01-31
DK489678A (en) 1979-05-04
FR2408142B1 (en) 1984-02-17
IL55856A (en) 1981-11-30
NO151099C (en) 1985-02-06

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee