GB2007220A - 2-Thio-2-Substituted Alkanoic Acid Derivatives - Google Patents

2-Thio-2-Substituted Alkanoic Acid Derivatives

Info

Publication number
GB2007220A
GB2007220A GB7833298A GB7833298A GB2007220A GB 2007220 A GB2007220 A GB 2007220A GB 7833298 A GB7833298 A GB 7833298A GB 7833298 A GB7833298 A GB 7833298A GB 2007220 A GB2007220 A GB 2007220A
Authority
GB
United Kingdom
Prior art keywords
substituted
alkyl
thio
phenyl
acid derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7833298A
Other versions
GB2007220B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP9827177A external-priority patent/JPS5432437A/en
Priority claimed from JP10682677A external-priority patent/JPS5441867A/en
Priority claimed from JP12350677A external-priority patent/JPS5459246A/en
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Publication of GB2007220A publication Critical patent/GB2007220A/en
Application granted granted Critical
Publication of GB2007220B publication Critical patent/GB2007220B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

2-thio-2-substituted- alkanoic acids of the formula <IMAGE> in which A represents isobutyl- or phenoxy-substituted phenyl or C1-4- alkyl-substituted thienyl, R<3> represents phenyl, C1-4-alkyl phenyl or C1-4 alkyl, R represents C1-4 alkyl and R<4> represents hydrogen or C1-4 alkyl, are obtained by alkylating 2- (aryl or alkylthio)-2-substituted acetic acids at the 2-position, followed by optional esterification. The 2(aryl- or alkylthio)-2 substituted acetic acids <IMAGE> may be obtained by condensing aldehydes (ACHO), haloform and mercaptans (R<3>SH), or in some cases, by reacting appropriately substituted 2,2,2-trihalo ethanol with mercaptans (R<3>SH). The compounds (I) are useful in the preparation of various anti- inflammatory agents.
GB7833298A 1977-08-18 1978-08-14 Process for preparing 2-thio-2-substituted alkanoic acid dricatives Expired GB2007220B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9827177A JPS5432437A (en) 1977-08-18 1977-08-18 2-thio-2-(3-phenoxyphenyl)alkane-carboxylic acid derivatives and their preparation
JP10682677A JPS5441867A (en) 1977-09-07 1977-09-07 Alpha-thio--alpha(2-thienyl)alkanoic acid derivative and its preparation
JP12350677A JPS5459246A (en) 1977-10-17 1977-10-17 2-thio-2-(4-isobutylphenyl) alkane acid derivatives and their preparation

Publications (2)

Publication Number Publication Date
GB2007220A true GB2007220A (en) 1979-05-16
GB2007220B GB2007220B (en) 1982-05-26

Family

ID=27308618

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7833298A Expired GB2007220B (en) 1977-08-18 1978-08-14 Process for preparing 2-thio-2-substituted alkanoic acid dricatives

Country Status (4)

Country Link
CA (1) CA1103684A (en)
DE (1) DE2836257A1 (en)
FR (1) FR2400507A1 (en)
GB (1) GB2007220B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3700732A1 (en) * 1987-01-13 1988-07-21 Boehringer Mannheim Gmbh NEW CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3584056A (en) * 1967-03-13 1971-06-08 Procter & Gamble Process for preparing alkali metal alkyl thiomethyl mercaptans by reaction of alkylthiomethylmetal compounds and sulfur

Also Published As

Publication number Publication date
FR2400507B1 (en) 1984-07-27
FR2400507A1 (en) 1979-03-16
GB2007220B (en) 1982-05-26
CA1103684A (en) 1981-06-23
DE2836257A1 (en) 1979-03-01

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee