GB2000508A - Thiazolidine compounds - Google Patents

Thiazolidine compounds

Info

Publication number
GB2000508A
GB2000508A GB7828177A GB7828177A GB2000508A GB 2000508 A GB2000508 A GB 2000508A GB 7828177 A GB7828177 A GB 7828177A GB 7828177 A GB7828177 A GB 7828177A GB 2000508 A GB2000508 A GB 2000508A
Authority
GB
United Kingdom
Prior art keywords
group
hydrogen atom
substituent
phenyl
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7828177A
Other versions
GB2000508B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP52078179A external-priority patent/JPS5834474B2/en
Priority claimed from JP9802477A external-priority patent/JPS6047264B2/en
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of GB2000508A publication Critical patent/GB2000508A/en
Application granted granted Critical
Publication of GB2000508B publication Critical patent/GB2000508B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

A compound of the formula: <IMAGE> or a pharmaceutically acceptable salt thereof, wherein R represents a hydrogen atom, a lower alkanoyl group, a lower alkylcarbamoyl group, a lower alkylthiocarbamoyl group or a lower alkoxycarbonyl group, R<1> represents a hydrogen atom or a methyl group, each of R<2> and R<3> represents a hydrogen atom, a lower alkyl group or a phenyl group which may be substituted by at least one substituent at any position(s) on the phenyl nucleus, each substituent being independently selected from a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxy group and a nitro group, or R<2> and R<2> together form an alkylene group. Such compounds are useful as anti-hypertensive agents.
GB7828177A 1977-06-29 1978-06-28 Thiazolidine compounds Expired GB2000508B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP52078179A JPS5834474B2 (en) 1977-06-29 1977-06-29 Method for producing thiazolidine derivatives
JP9802477A JPS6047264B2 (en) 1977-08-15 1977-08-15 Thiazolidine derivatives

Publications (2)

Publication Number Publication Date
GB2000508A true GB2000508A (en) 1979-01-10
GB2000508B GB2000508B (en) 1982-05-19

Family

ID=26419266

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7828177A Expired GB2000508B (en) 1977-06-29 1978-06-28 Thiazolidine compounds

Country Status (7)

Country Link
DE (1) DE2828578C2 (en)
ES (1) ES471239A1 (en)
FR (1) FR2395998A1 (en)
GB (1) GB2000508B (en)
IT (1) IT1105731B (en)
NL (1) NL7807023A (en)
SE (1) SE434836B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2440365A1 (en) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them
EP0086453A2 (en) * 1982-02-09 1983-08-24 LUITPOLD-WERK Chemisch-pharmazeutische Fabrik GmbH &amp; Co. Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
US4457935A (en) * 1978-04-08 1984-07-03 Santen Pharmaceutical Co., Ltd. Antihypertensive 4-thiazolidinecarboxylic acids (substituted phenyl derivatives)
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4822818A (en) * 1980-10-31 1989-04-18 Takeda Chemical Industries, Ltd. Bicycle compounds, their production and use

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
DE3011239A1 (en) * 1980-03-22 1981-10-01 C.H. Boehringer Sohn, 6507 Ingelheim SUBSTITUTED ALKYLTHIOACYLAMINO ACIDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS
JPS56139455A (en) 1980-04-02 1981-10-30 Santen Pharmaceut Co Ltd Sulfur-containing acylaminoacid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2446100C3 (en) * 1974-09-26 1982-01-14 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Phenoxyalkanecarboxamides of thiazolidinecarboxylic acids, process for their preparation and pharmaceuticals
AU518147B2 (en) * 1976-12-03 1981-09-17 E.R. Squibb & Sons, Inc. Derivatives of thiazolidine, thiazine and morpholine carboxylic acids
JPS5455565A (en) * 1977-10-06 1979-05-02 Santen Pharmaceut Co Ltd Novel thiazolidine derivative

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4457935A (en) * 1978-04-08 1984-07-03 Santen Pharmaceutical Co., Ltd. Antihypertensive 4-thiazolidinecarboxylic acids (substituted phenyl derivatives)
FR2440365A1 (en) * 1978-10-31 1980-05-30 Santen Pharmaceutical Co Ltd NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS
EP0031104A1 (en) * 1979-12-13 1981-07-01 Santen Pharmaceutical Co., Ltd. Thiazolidine compounds, processes for their preparation and pharmaceutical compositions containing them
US4822818A (en) * 1980-10-31 1989-04-18 Takeda Chemical Industries, Ltd. Bicycle compounds, their production and use
EP0086453A2 (en) * 1982-02-09 1983-08-24 LUITPOLD-WERK Chemisch-pharmazeutische Fabrik GmbH &amp; Co. Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
EP0086453A3 (en) * 1982-02-09 1984-03-07 Luitpold-Werk Chemisch-Pharmazeutische Fabrik Gmbh & Co. Thiazaspiro derivatives, process for their preparation and pharmaceutical composition
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension

Also Published As

Publication number Publication date
IT1105731B (en) 1985-11-04
NL7807023A (en) 1979-01-03
DE2828578A1 (en) 1979-01-11
ES471239A1 (en) 1979-01-16
SE7807335L (en) 1978-12-30
DE2828578C2 (en) 1983-12-15
FR2395998B1 (en) 1982-07-23
IT7850037A0 (en) 1978-06-27
SE434836B (en) 1984-08-20
GB2000508B (en) 1982-05-19
FR2395998A1 (en) 1979-01-26

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Legal Events

Date Code Title Description
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee