GB1595168A - Expoxysuccinic acid derivatives - Google Patents
Expoxysuccinic acid derivatives Download PDFInfo
- Publication number
- GB1595168A GB1595168A GB4717/78A GB471778A GB1595168A GB 1595168 A GB1595168 A GB 1595168A GB 4717/78 A GB4717/78 A GB 4717/78A GB 471778 A GB471778 A GB 471778A GB 1595168 A GB1595168 A GB 1595168A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- epoxysuccinate
- cor
- formula
- potassium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 150000004702 methyl esters Chemical class 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- UJQMLHKSZKBMMO-UHFFFAOYSA-N n,n-diethylethanamine;pyridine Chemical compound C1=CC=NC=C1.CCN(CC)CC UJQMLHKSZKBMMO-UHFFFAOYSA-N 0.000 description 1
- CZFNISFYDPIDNM-UHFFFAOYSA-N n,n-dimethylformamide;oxolane Chemical compound CN(C)C=O.C1CCOC1 CZFNISFYDPIDNM-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- KVNYFPKFSJIPBJ-UHFFFAOYSA-N ortho-diethylbenzene Natural products CCC1=CC=CC=C1CC KVNYFPKFSJIPBJ-UHFFFAOYSA-N 0.000 description 1
- DCEMCPAKSGRHCN-UHFFFAOYSA-L oxirane-2,3-dicarboxylate Chemical compound [O-]C(=O)C1OC1C([O-])=O DCEMCPAKSGRHCN-UHFFFAOYSA-L 0.000 description 1
- 125000000466 oxiranyl group Chemical group 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- KBGJIKKXNIQHQH-UHFFFAOYSA-N potassium;methanidylbenzene Chemical compound [K+].[CH2-]C1=CC=CC=C1 KBGJIKKXNIQHQH-UHFFFAOYSA-N 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- DMBCZKSNUJRXCN-UHFFFAOYSA-N propyl 3-[(2-oxo-2-phenylmethoxyethyl)carbamoyl]oxirane-2-carboxylate Chemical compound C(C1=CC=CC=C1)OC(CNC(=O)C1OC1C(=O)OCCC)=O DMBCZKSNUJRXCN-UHFFFAOYSA-N 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960002898 threonine Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 229960004799 tryptophan Drugs 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52023092A JPS6059232B2 (ja) | 1977-03-03 | 1977-03-03 | エポキシサクシニルアミノ酸誘導体 |
| JP2353777A JPS6037105B2 (ja) | 1977-03-04 | 1977-03-04 | エポキシコハク酸モノエステル化合物 |
| JP52023536A JPS6037104B2 (ja) | 1977-03-04 | 1977-03-04 | エポキシコハク酸モノエステル誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1595168A true GB1595168A (en) | 1981-08-12 |
Family
ID=27284115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4717/78A Expired GB1595168A (en) | 1977-03-03 | 1978-02-06 | Expoxysuccinic acid derivatives |
Country Status (5)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507297A (en) * | 1981-04-10 | 1985-03-26 | Nippon Chemiphar Co., Ltd. | Piperazine derivatives and a medicine containing the same |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5547668A (en) * | 1978-09-30 | 1980-04-04 | Taisho Pharmaceut Co Ltd | Epoxysuccinamic acid |
| JPS55115878A (en) * | 1979-02-27 | 1980-09-06 | Taisho Pharmaceut Co Ltd | Epoxysuccinic acid derivative |
| JPS55153778A (en) | 1979-05-17 | 1980-11-29 | Taisho Pharmaceut Co Ltd | Epoxysuccinylamino acid derivative |
| JPS56104816A (en) * | 1980-01-25 | 1981-08-20 | Nippon Chemiphar Co Ltd | Preventive and remedy for caridac infarction |
| US4474800A (en) * | 1980-05-13 | 1984-10-02 | Taisho Pharmaceutical Co., Ltd. | Epoxysuccinyl amino acid derivatives |
| JPS6276A (ja) * | 1985-03-26 | 1987-01-06 | Toyo Jozo Co Ltd | 酵素阻害性新規物質 |
| CA2389233A1 (en) | 1999-10-29 | 2001-05-10 | Paul K. S. Nam | Oligomers and oligomeric segments of alpha-hydroxy carboxylic acids and alpha-amino acids |
| US6939693B2 (en) * | 1999-10-29 | 2005-09-06 | Novus International, Inc. | Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids |
| CN107151236B (zh) | 2016-03-03 | 2021-04-30 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种2,3-环氧丁二酰衍生物及其制备方法和用途 |
| EP4140542A1 (en) * | 2021-08-24 | 2023-03-01 | Centre National De La Recherche Scientifique (Cnrs) | New vashs inhibitors, conjugates thereof and their uses as drugs or as research tools |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS548759B2 (US08188275-20120529-C00054.png) * | 1973-03-06 | 1979-04-18 | ||
| GB1469797A (en) * | 1974-11-07 | 1977-04-06 | Pfizer Ltd | Antibacterial cephalosporin derivatives |
-
1978
- 1978-02-06 GB GB4717/78A patent/GB1595168A/en not_active Expired
- 1978-02-21 FR FR7804933A patent/FR2382447A1/fr active Granted
- 1978-02-22 US US05/880,180 patent/US4393228A/en not_active Expired - Lifetime
- 1978-03-02 DE DE19782809036 patent/DE2809036A1/de active Granted
- 1978-03-03 CH CH229778A patent/CH629492A5/fr not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507297A (en) * | 1981-04-10 | 1985-03-26 | Nippon Chemiphar Co., Ltd. | Piperazine derivatives and a medicine containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2382447B1 (US08188275-20120529-C00054.png) | 1981-07-31 |
| DE2809036A1 (de) | 1978-09-07 |
| CH629492A5 (fr) | 1982-04-30 |
| DE2809036C2 (US08188275-20120529-C00054.png) | 1987-01-08 |
| FR2382447A1 (fr) | 1978-09-29 |
| US4393228A (en) | 1983-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |