GB1591029A - Hematology parameter measuring apparatus - Google Patents
Hematology parameter measuring apparatus Download PDFInfo
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- GB1591029A GB1591029A GB43504/76A GB4350476A GB1591029A GB 1591029 A GB1591029 A GB 1591029A GB 43504/76 A GB43504/76 A GB 43504/76A GB 4350476 A GB4350476 A GB 4350476A GB 1591029 A GB1591029 A GB 1591029A
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- 238000004820 blood count Methods 0.000 claims abstract description 32
- 238000005534 hematocrit Methods 0.000 claims abstract description 27
- 102000001554 Hemoglobins Human genes 0.000 claims description 32
- 108010054147 Hemoglobins Proteins 0.000 claims description 32
- 210000003743 erythrocyte Anatomy 0.000 claims description 21
- 210000000265 leukocyte Anatomy 0.000 claims description 8
- 230000004044 response Effects 0.000 claims description 7
- 238000005259 measurement Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 3
- 230000000881 depressing effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 8
- 238000010276 construction Methods 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000000601 blood cell Anatomy 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 239000003990 capacitor Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 101150038956 cup-4 gene Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N15/131—Details
- G01N15/132—Circuits
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- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
This analyser has a recording apparatus (16) with counters (17-20) for measured blood values, a display unit (38) and a computer (42). This analyser can be used to measure, for example, the red and white blood count, haemoglobin and haematocrit. Before the digital pulses of blood values measured by the recording apparatus (16) and of the blood values calculated by the computer (42) are fed to a printer (44) the relevant blood values can be read off the display unit (38). This permits a considerable saving of report cards. <IMAGE>
Description
(54) HEMATOLOGY PARAMETER MEASURING APPARATUS
(71) We, HYCEL, INC., a Corporation organised under the laws of the State of
Delaware, United States of America, of 7920 Westpark Drive, Houston, State of
Texas 77036, United States of America, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:
This invention relates to hematology measuring apparatus for producing outputs indicative of measured valuers and calculated values, certain parameters being measured directly, and other parameters being provided by a calculation performed within the apparatus.
The context contemplated for the present invention is the type of hematology counting apparatus in which blood cells in a blood dilution sample pass through an aperture in a conductivity sensor and in which electrical output pulses from the conductivity sensor are provided indicative of the number of cells in a sample. The apparatus further includes colorimetric hemoglobin measurement apparatus. An example of such an apparatus is disclosed in a U.S. Patent No.
3,921,066 issued to Henry R. Angel, et al on
November 18, 1975. Further, it is desired to provide improvement in an apparatus which further calculates hematocrit of a blood sample. Hematocrit is the percentage of the volume of red blood cells in a sample in relation to the volume of the blood in the sample. An example of such a circuit for use in a hematology measurement apparatus is shown in U.S. Patent No. 3,828,260 issued to Underwood on August 6, 1974.
In the present apparatus, a measurement is made on a blood dilution sample, and signals indicative of the above-described parameters are generated such as in the manner described in the above-cited patents. The signals are then converted into digital form and stored in digital registers.
Each of the signals may drive display circuitry to provide a visual indication of the values of parameters measured for the sample. Additionally, circuitry is provided to produce further calculated parameters, such as mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin and mean corpuscular volume for provision to further data utilization means. These data utilization means preferably circuitry for printing out values of measured and calculated parameters.
In order to do this, a control circuit causes the circulation of values from each register to digital dividing circuitry. A first parameter is circulated into a digital divider through a digital data line to set a divisor in the data circuit. The control circuit then connects a pulse count having a value indicative of the value in another register for utilization as the signal indicating the dividend supply to the digital divider. This operation is repeated for each calculated parameter desired to be obtained. For example, to obtain mean corpuscular volume, a pulse count indicative of the red blood cell count is mounted into the digital divider. Then, a pulse count indicative of hematocrit is applied to the digital divider, which produces a pulse count output indicating mean corpuscular volume. This pulse count is provided to a further register for connection to utilization means such as a printer and print/out card.
The main object of the invention is to provide as improved automatic hematology parameter measurement apparatus and method in which measured parameters are provided and converted into digital form to registers, selected parameters being circulated to digital divider circuits for use individually as divisors, and in proper sequence, individual stored digital values being circulated to the digital divider for use as dividends, each digital divider providing an output indicative of a calculated parameter for use by further utilization means, such as a printer. A further object of the present invention is to provide hematology parameter data such that only certain output values are avilable for viewing by a technician before all parameter values are provided for printing on a report form.
According to the present invention there is provided a hematology parameter measuring apparatus, for producing outputs indicative of measured values, including transducer means for producing signals indicative of parameter values, and register means for storing indications of measured values, characterised by means for producing calculated parameter values comprising:
(i) calculation means, for calculating a calculated value as a function of measured values supplied thereto, comprising a digital divider having a dividend register and a divisor register, control means for commanding generation of calculated parameter values, and means for supplying preselected measured values from said register means in a preselected sequence to said calculation means in response to an input from said control means, said register means comprising parameter registers, said means for supplying preselected measured values comprising means for circulating a value from one of said parameter registers to one of said registers in said digital divider, and applying a source of clock pulses for incrementing said parameter register by a number of counts to return to its original setting; and sensing the overflow of said parameter register, and
(ii) means for providing to a register in said digital divider at least the number of counts provided to the parameter register after overflow until the provision of the number of counts to the parameter register is completed, whereby said calculation means provides an output indicative of a calculated value.
The construction of the apparatus permits the display of parameters with which a technician operating the apparatus is familiar. The technician may then provide a report card to the system to print out both the display parameters and further calculated parameters. By permitting the technician to examine the familiar parameters first, expense in use of cards is reduced.
Further, the technician need not use print report cards for calibration samples. As well as providing for improvement in operation, the construction is improved in that parameters obtained by prior art methods are very efficiently utilized with a minimum amount of additional circuitry to provide further calculated parameters.
Further according to the invention there is provided a method, for producing parameter values in a hematology measuring apparatus, including steps of producing signals indicative of measured values, and storing said signals in register means, char- acterised by the steps of:
(i) providing calculation means comprising a digital divider having a dividend register and a divisor register for producing calculated values as a function of measured values supplied thereto,
(ii) providing in response to a command preselected ones of said measured values in a predetermined sequence to said calculation means, a first measured value being provided from a first register to the dividend register and a second measured value being provided from a second register to said divisor register,
(iii) providing a value from a register to said calculating means by providing a number of counts to said register to return said register to its original setting, sensing reset of said register, and providing at least the number of counts produced after reset to said calculation means, whereby a value indicative of said calculated value from said calculation means is provided.
An embodiment of apparatus in accordance with the invention is hereinafter particularly described with reference to the accompanying drawings, wherein:
Figure 1 is a block diagram of an apparatus constructed in accordance with the present invention,
Figure 2 is a schematic diagram of digital data handling means for providing calculated output parameters in the system of
Figure 1.
Making reference to the figures, and particularly to Figure 1, the automatic hematology apparatus according to the present invention is shown. A hematology measuring apparatus 1 which may be constructed in accordance with the above-cited patent to Angel is provided for producing measured parameter outputs indicative of red blood cell count, white blood cell count, and hemoglobin of the sample. Additionally, an output indicative of hematocrit is also provided, and the hematocrit circuit may be constructed in accordance with the abovecited patent to Underwood. Since a full description of one type of circuitry which may be used in the present invention may be found in these published patents, the system is briefly described here. A conductivity sensor 2 is provided for sensing blood cells in a sample 3 held by a sample cup 4. Pulses indicative of an uncorrected blood cell count are provided to a buffer amplifier 5 providing an output to a comparator 6. The comparator 6 may compare the outputs to the amplifier 5 to separate threshold levels for red blood cell counts and for white blood cell counts. Reference voltage levels to the comparator 6 are provided by conventional means (not shown).
Blood cell counts are provided from the comparator 6 through a selectable ratio divider 7 to a coincidence correction circuit 8 providing pulse outputs indicative of corrected blood cell counts. The division ratio of the divider 7 is selected by a control circuit 10, which may operate in response to function selection buttons 9 electrically interfaced thereto, such as those in the apparatus according to the above-cited Angel patent. The control circuit 10 also includes conventional timing circuitry for synchronizing further operation as described below.
The output of the coincidence correction circuit 8 is provided to switching means 12, also controlled by the control circuit 10 to selectively provide a white blood cell count or a red blood cell count to a register means 16. The register means 16 includes multistage registers and data interface circuitry.
The register means 16 includes registers 17, 18, 19 and 20, each for respectively storing a digital representation corresponding to the value of white blood cell count, red blood cell count, hemoglobin, and hematocrit for a sample.
A hematocrit circuit 22 is provided having inputs connected to the output of the amplifier 5 and the comparator 6 for providing an analog output indicative of hematocrit for a sample, such as in the manner described in the above-cited Underwood patent. The output of the hematocrit circuit 22 is provided to a memory circuit 24. The memory circuit 24 preferably includes storage capacitors for storing analog values. A hemoglobin output signal is provided by a hemoglobinometer 23, which may be of conventional construction and which provides an input to a further input of the memory circuit 24.
Stored values of hematocrit and hemoglobin are respectively coupled from the memory circuit 24 by first and second potentiometers 25 and 26 respectively, each having outputs coupled to a switching means 28.
The potentiometers 25 and 26 are used to calibrate hemoglobin and hematocrit output levels of reference standards such that an analog output value corresponding to a predetermined reference level may be obtained. This construction is advantageous in that it permits calibration while a particular value is held in the memory circuit 24.
The switching means 28 selectively couples the output of the potentiometer 25 or 26 to an analog to digital converter 30. The analog to digital converter 30 provides an output to a switching means 32 so that the output of the analog to digital converter 30 is selectively connected to the hemoglobin register 19 or the hematocrit register 20.
The switching means 28 and 32 are operated by the control circuit 10 to selectively couple values indicative of hemoglobin or hematocrit to the register means 16 at separate times during operation on one sample.
A first data bus 36 connects outputs in proper sequence from the register means 16 to a display means 38. The data bus 36 is illustrated as a wide line to indicate that digital values are provided from the register means 16 to the display means 38. The display means 38 includes conventional decoder circuitry, display driver circuitry, and display means. Other utilization means could be provided if desired, such as recorders or other forms of data handling circuitry.
A second data bus 40 couples the register means 16 to a calculator means 42 which provides an output to utilization means in the form of a printer circuit 44. The calculator means 42 includes conventional circuitry for coupling the information from the register means 16 to the printing means 44.
Further, the calculation means 42 comprises means for further providing calculated parameter values in a manner further described below with respect to Figure 2. The printer unit 44 receives a report card form and includes conventional means for translating electrical values of parameters supplied thereto, into human readable printed intelligence. The printing unit 44 could be replaced by other utilization means such as a direct input to a computer storage or may comprise data interface for other data processing means. The example of a printer unit is utilized in this description since this will be a preferred form of utilization means in hospital laboratory use.
The calculator means 42 is utilized to efficiently provide calculator values such as mean corpuscular volume, MCV, which is equal to the quotient of hematocrit divided by red blood cell count, mean corpuscular hemoglobin, MCH, which is equivalent to the quotient of the value of the hemoglobin result divided by the red blood cell count, and mean corpuscular hemoglobin concentration, MCHC, which is the equivalent to the quotient of the values of hemoglobin provided by the value of hematocrit.
Figure 2 is a schematic illustration of the circuitry for utilizing the values provided to the register means 16 to provide the aboverecited calculated values. Conventional data translation circuitry is now shown. The same reference numerals are used to denote components corresponding to those in Figure 1.
In the calculator means 42, a data clock 50 is provided connected to a decoder and gate circuit 52. The decoder and gate circuit 52 connects the clock 50 selectively at times determined as described below for in crementing one of the registers 17 through 20. A count sufficient to cause the register 17, 18, 19 or 20 to reset and return to its setting indicative of a parameter value is utilized. For example, if each of the registers 17 - 20 are three-stage decimal counters, then a count of one thousand is provided from the clock 50. Since the registers have only three stages, the carry-over when a count reaches one thousand is lost, and at the end of a count of one thousand, each register retains the same value it did before the count. The number of counts occurring after an overflow condition occurs equals the number of counts initially set in the register 17, 18, 19 or 20. This operation is utilized as further described below for circulating values from the register means 16 to the calculator 42.
In order to determine when a value will be circulated, a calculator control circuit 54 is preset with an operating sequence. At predetermined times, it provides output numbers to an address circuit 56 having addressing outputs connected to the decoder circuit 52. The decoder and gate circuit 52 connect the output of the clock circuit 50 to one of the registers 17, 18, 19 or 20 for an appropriate amount of time in response to the input from the address circuit 56.
A signal indicative of the overflow, or the time at which a count again will begin indicative of the initial value in a register 17, 18, 19 or 20 is provided to a gate circuit 58.
This operation is utilized for circulating the value from the register means 16 to a digital divider 60. The digital divider 60 comprises a divisor register 62, a comparator 64, and a dividend register 66. The comparator 64 provides separate outputs, each consisting of a digital count sequentially to the printer circuit 44 indicative of the above-calculated values.
For example, when the preset sequence of the calculator control circuit 54 determines that mean corpuscular volume will be computed, a value indicative of the red blood cell count is provided to the divisor register 62, and a value indicative of the hematocrit is circulated to the dividend register 66. This is accomplished in the following manner. A gate 72 is connected to the output of the clock 50 and has a further output connected to a gate 74 which in turn delivers a counting input into the divisor register 62. The AND gate 72 has a second input connected thereto from gate circuit 58 so that provision of clock pulses to the gate 74 is enabled. The gate 74 has a second input thereto from the calculator control 54 which enables the gate 74 to provide counts to the divisor register 62 only while the one thousand count is provided to the red blood cell count register
18. Consequently, the time during which input counts are supplied to the divisor register 62 is equal to the intersection of the time period during which a one thousand count is provided and the time period after which the register 18 has overflowed. Therefore, the count provided in the divisor register 62 will be equal to the red blood cell count value in the register 18.
Similarly, in order to circulate a number dependent upon a number in a parameter register to the dividend register 66, a gate 76 is connected between clock circuit 50 and a counting input of the dividend register 66. A scaling circuit 78 may be connected in series between the clock 50 and the gate 76 to provide for decimal point adjustment in the value to be provided to the dividend register 66. The gate 76 also has input from the control circuit 54 and the gate circuit 58 to provide for a similar time period intersection in which counts are applied to the dividend register 66.
In the preferred form of operation, the above described sequence is followed, and the value of the red blood cell count is circulated from the register 18 to the divisor register 62. Subsequently, at times commanded by the preset sequence in the calculator control circuit 54, a count is provided from the register 20 equal to the hematocrit value to the dividend register 66. The divisor register 62 provides an output pulse from the output of the comparator 64 every time they are equal, and also resets the dividend register 66 so that this operation may be repeated. In this manner, division is achieved. In order to provide this operation, the divisor register 62 and comparator 64 may be comprised for example of an RCA 4585 microcircuit chip ("RCA" is a Registered Trade Mark) which comprises both register and comparator stages. The dividend register 66 is chosen to have an equal number of stages to the divisor and comparator combination. Output pulses from the comparator 64 are stored in a register in the printing system 44 for use in a conventional manner. The printing system 44 includes conventional means for handling separate calculated values provided thereto at separate times. Similarly, to calculate mean corpuscular hemoglobin, the red blood cell count value is circulated from the register 18 to the divisor register 62, and subsequently, the hemoglobin value is circulated from the register 20 to the dividend register 66 for a similar operation. At a subsequent time period, to provide a calculated value indicative of mean corpuscular hemoglobin concentration, the hematocrit value is circulated from the register 20 to the divisor register 62, and thereafter the hemoglobin value is circulated from the register 19 into the dividend register 66 so that the number of output pulses provided from the comparator 64 is indicative of mean corpuscular hemoglobin concentration.
The white blood cell count, red blood cell count, hemoglobin, and hematocrit values are provided to the printing system 44 in a conventional manner. In this manner, calculated values are efficiently produced and ease of operation is enhanced.
The calculated values are provided to utilization means for viewing by an operator or for storage. Utilization means preferably comprise the printer 44 and the display 38.
The selection buttons 9 include a "print" button and a "display" button. By depressing the "print" button of the selection buttons 9, the control circuit is actuated to couple signals indicative of measured and calculated values to the printer 44 for printing on a print card. However, in accordance with the present invention, it is not necessary to use a print card to view measured and calculated parameter values.
By depression of the "display" button of the selection buttons 9, parameter values are selectively provided to the display 38 through appropriate elements of the circuitry described above operated by the control circuit 10. In this manner, the operator can preview results obtained and determine whether it is desirable to perform another test on the sample 3 before reporting results on a print card. Also, results of tests on calibration samples are available to the operator when production of a printed card is not necessary.
Improvements are thus provided in obtaining values and providing values to utilization means in a hematology parameter measurement apparatus.
WHAT WE CLAIM IS:
1. A hematology parameter measuring apparatus, for producing outputs indicative of measured values, including transducer means for producing signals indicative of parameter values and register means for storing indications of measured values characterised by means for producing calculated parameter values comprising:
(i) calculation means, for calculating a calculated value as a function of measured values supplied thereto, comprising a digital divider having a dividend register and a divisor register, control means for commanding generation of calculated parameter values, and means for supplying preselected measured values from said register means in a preselected sequence to said calculation means in response to an input from said control means, said register means comprising parameter registers, said means for supplying preselected measured values comprising means for circulating a value from one of said parameter registers to one of said registers in said digital divider, and applying a source of clock pulses for incrementing said parameter register by a number of counts to return to its original setting, and sensing the overflow of said parameter register, and
(ii) means for providing to a register in said digital divider at least the number of counts provided to the parameter register after overflow until the provision of the number of counts to the parameter register is completed, whereby said calculation means provides an output indicative of a calculated value.
2. Apparatus, according to claim 1, wherein said means for circulating a value from one of said parameter registers to said divisor register comprises means for providing to said divisor register a number of counts equal to counts occurring after overflow until the provision of the number of counts to the parameter register is completed.
3. Apparatus, according to claim 1, wherein said means for circulating a value from one of said parameter registers to said dividend register comprises means for providing to said divident register a multiple of the number of counts provided to the parameter register after overflow until the provision of the number of counts provided to the parameter register is completed, which multiple is equal to a scaling factor.
4. Apparatus, according to any one- of claims 1 to 3, wherein said parameter registers comprise a white blood cell count register, red blood cell count register, hemoglobin register, and hematocrit register, and wherein said means for supplying preselected measured values comprises means for accessing a value from each parameter register indicative of the parameter by which the parameter register is named.
5. Apparatus, according to claim 4 wherein said means for supplying preselected measured values comprises means for circulating a value from the red blood cell count register to the divisor register and for circulating a value dependent upon the value in the hematocrit register to dividend register whereby said digital divider provides an output indicative of mean corpuscular volumne, means for circulating a value indicative of the value in the red blood cell count register to the divisor register and circulating a value based on the value in the hemoglobin register to said dividend register, whereby said digital divider provides an output indicative of means corpuscular hemoglobin, and means for circulating a value from said hematocrit register to said divisor register and for circulating a value based on the value in the hemoglobin register to the dividend register, whereby said digital divider provides an output indicative of means corpuscular hemoglobin concentration.
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (7)
1. A hematology parameter measuring apparatus, for producing outputs indicative of measured values, including transducer means for producing signals indicative of parameter values and register means for storing indications of measured values characterised by means for producing calculated parameter values comprising:
(i) calculation means, for calculating a calculated value as a function of measured values supplied thereto, comprising a digital divider having a dividend register and a divisor register, control means for commanding generation of calculated parameter values, and means for supplying preselected measured values from said register means in a preselected sequence to said calculation means in response to an input from said control means, said register means comprising parameter registers, said means for supplying preselected measured values comprising means for circulating a value from one of said parameter registers to one of said registers in said digital divider, and applying a source of clock pulses for incrementing said parameter register by a number of counts to return to its original setting, and sensing the overflow of said parameter register, and
(ii) means for providing to a register in said digital divider at least the number of counts provided to the parameter register after overflow until the provision of the number of counts to the parameter register is completed, whereby said calculation means provides an output indicative of a calculated value.
2. Apparatus, according to claim 1, wherein said means for circulating a value from one of said parameter registers to said divisor register comprises means for providing to said divisor register a number of counts equal to counts occurring after overflow until the provision of the number of counts to the parameter register is completed.
3. Apparatus, according to claim 1, wherein said means for circulating a value from one of said parameter registers to said dividend register comprises means for providing to said divident register a multiple of the number of counts provided to the parameter register after overflow until the provision of the number of counts provided to the parameter register is completed, which multiple is equal to a scaling factor.
4. Apparatus, according to any one- of claims 1 to 3, wherein said parameter registers comprise a white blood cell count register, red blood cell count register, hemoglobin register, and hematocrit register, and wherein said means for supplying preselected measured values comprises means for accessing a value from each parameter register indicative of the parameter by which the parameter register is named.
5. Apparatus, according to claim 4 wherein said means for supplying preselected measured values comprises means for circulating a value from the red blood cell count register to the divisor register and for circulating a value dependent upon the value in the hematocrit register to dividend register whereby said digital divider provides an output indicative of mean corpuscular volumne, means for circulating a value indicative of the value in the red blood cell count register to the divisor register and circulating a value based on the value in the hemoglobin register to said dividend register, whereby said digital divider provides an output indicative of means corpuscular hemoglobin, and means for circulating a value from said hematocrit register to said divisor register and for circulating a value based on the value in the hemoglobin register to the dividend register, whereby said digital divider provides an output indicative of means corpuscular hemoglobin concentration.
6. A method, for producing parameter
values in a hematology parameter measuring apparatus, including steps of producing signals indicative of measured values, and storing said signals in register means, characterised by the steps of:
(i) providing calculation means comprising a digital divider having a dividend register and a divisor register for producing calculated values as a function of measured values supplied thereto,
(ii) providing in response to a command preselected ones of said measured values in a predetermined sequence to said calculation means, a first measured value being provided from a first register to the dividend register and a second measured value being provided from a second register to said divisor register,
(iii) providing a value from a register to said calculating means by providing a number of counts to said register to return said register to its original setting, sensing reset of said register, and providing at least the number of counts produced after reset to said calculation means, whereby a value indicative of said calculated value from said calculation means is provided.
7. The method according to claim 6 further comprising the step of providing a result register and providing the signal indicative of each calculated value to a location in a result register.
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB43504/76A GB1591029A (en) | 1976-10-20 | 1976-10-20 | Hematology parameter measuring apparatus |
| SE7711392A SE7711392L (en) | 1976-10-20 | 1977-10-11 | APPARATUS FOR META HEMATOLOGY PARAMETERS |
| CH1254877A CH626728A5 (en) | 1976-10-20 | 1977-10-14 | Automatic blood analyser |
| FR7731243A FR2368759A1 (en) | 1976-10-20 | 1977-10-18 | HEMATOLOGICAL PARAMETERS MEASUREMENT DEVICE |
| CA289,070A CA1114063A (en) | 1976-10-20 | 1977-10-19 | Calculated parameter generation in a hematology parameter measurement apparatus |
| DE19772747193 DE2747193A1 (en) | 1976-10-20 | 1977-10-20 | MEASURING DEVICE FOR MEASURING HAEMATOLOGY PARAMETERS |
| JP12638977A JPS5353398A (en) | 1976-10-20 | 1977-10-20 | Operating system for blood parameter measurements |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB43504/76A GB1591029A (en) | 1976-10-20 | 1976-10-20 | Hematology parameter measuring apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1591029A true GB1591029A (en) | 1981-06-10 |
Family
ID=10429033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB43504/76A Expired GB1591029A (en) | 1976-10-20 | 1976-10-20 | Hematology parameter measuring apparatus |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS5353398A (en) |
| CA (1) | CA1114063A (en) |
| CH (1) | CH626728A5 (en) |
| DE (1) | DE2747193A1 (en) |
| FR (1) | FR2368759A1 (en) |
| GB (1) | GB1591029A (en) |
| SE (1) | SE7711392L (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4843869A (en) * | 1988-03-21 | 1989-07-04 | Levine Robert A | Method for measuring hemoglobin |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5435434B2 (en) * | 1973-11-13 | 1979-11-02 |
-
1976
- 1976-10-20 GB GB43504/76A patent/GB1591029A/en not_active Expired
-
1977
- 1977-10-11 SE SE7711392A patent/SE7711392L/en unknown
- 1977-10-14 CH CH1254877A patent/CH626728A5/en not_active IP Right Cessation
- 1977-10-18 FR FR7731243A patent/FR2368759A1/en not_active Withdrawn
- 1977-10-19 CA CA289,070A patent/CA1114063A/en not_active Expired
- 1977-10-20 JP JP12638977A patent/JPS5353398A/en active Pending
- 1977-10-20 DE DE19772747193 patent/DE2747193A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5353398A (en) | 1978-05-15 |
| SE7711392L (en) | 1978-04-21 |
| DE2747193A1 (en) | 1978-05-24 |
| CA1114063A (en) | 1981-12-08 |
| FR2368759A1 (en) | 1978-05-19 |
| CH626728A5 (en) | 1981-11-30 |
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| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |