GB1582234A - Morphine derivatives - Google Patents

Morphine derivatives Download PDF

Info

Publication number
GB1582234A
GB1582234A GB34195/76A GB3419576A GB1582234A GB 1582234 A GB1582234 A GB 1582234A GB 34195/76 A GB34195/76 A GB 34195/76A GB 3419576 A GB3419576 A GB 3419576A GB 1582234 A GB1582234 A GB 1582234A
Authority
GB
United Kingdom
Prior art keywords
compound
minutes
reaction
mixture
thebaine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34195/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Macfarlan Smith Ltd
Original Assignee
Macfarlan Smith Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macfarlan Smith Ltd filed Critical Macfarlan Smith Ltd
Priority to GB34195/76A priority Critical patent/GB1582234A/en
Priority to IL52632A priority patent/IL52632A/xx
Priority to AU27549/77A priority patent/AU517187B2/en
Priority to US05/821,834 priority patent/US4140687A/en
Priority to YU1948/77A priority patent/YU40008B/xx
Priority to CA284,635A priority patent/CA1085834A/en
Priority to DE19772736260 priority patent/DE2736260A1/de
Priority to BE180138A priority patent/BE857753A/xx
Priority to FR7724867A priority patent/FR2362144A1/fr
Priority to NL7709024A priority patent/NL7709024A/xx
Priority to NO772852A priority patent/NO772852L/no
Priority to PL1977200323A priority patent/PL104043B1/pl
Priority to JP9861477A priority patent/JPS5323998A/ja
Priority to HU77MA2905A priority patent/HU176841B/hu
Publication of GB1582234A publication Critical patent/GB1582234A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB34195/76A 1976-08-17 1976-08-17 Morphine derivatives Expired GB1582234A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB34195/76A GB1582234A (en) 1976-08-17 1976-08-17 Morphine derivatives
IL52632A IL52632A (en) 1976-08-17 1977-08-01 Process for conversion of thebaine to codeine and the novel 8 halodihydrocodeinone hydrohalide intermediate therefor
AU27549/77A AU517187B2 (en) 1976-08-17 1977-08-02 Morphine derivatives
US05/821,834 US4140687A (en) 1976-08-17 1977-08-04 Process for the preparation of 8-halodihydrocodeinone hydrohalides and codeine
YU1948/77A YU40008B (en) 1976-08-17 1977-08-09 Process for obtaining 8-halohydrocodeinne halohydrates
CA284,635A CA1085834A (en) 1976-08-17 1977-08-09 8-halodihydrocodeinone hydrohalide and process for their preparation
DE19772736260 DE2736260A1 (de) 1976-08-17 1977-08-11 Dihydrocodeinonderivate
BE180138A BE857753A (fr) 1976-08-17 1977-08-12 Derives de la dihydrocodeinone, leur preparation et leur emploi
FR7724867A FR2362144A1 (fr) 1976-08-17 1977-08-12 Derives de la dihydrocodeinone, leur preparation et leur emploi dans la synthese de la codeine
NL7709024A NL7709024A (nl) 1976-08-17 1977-08-16 Dihydrocodeiinon-derivaten, werkwijze voor het bereiden daarvan en werkwijze voor het met be- hulp van deze derivaten bereiden van codeinon en codeine.
NO772852A NO772852L (no) 1976-08-17 1977-08-16 Dihydrokodeinon-derivater og fremgangsm}te for fremstilling derav
PL1977200323A PL104043B1 (pl) 1976-08-17 1977-08-17 Sposob wytwarzania nowych pochodnych kodeinonu
JP9861477A JPS5323998A (en) 1976-08-17 1977-08-17 Production of dihydrocodeine novel derivative and use of said derivative in codeinone and codeine making
HU77MA2905A HU176841B (en) 1976-08-17 1977-08-17 Process for producing 8-halogeno-dihydro-codeinone-hydrohalogenides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB34195/76A GB1582234A (en) 1976-08-17 1976-08-17 Morphine derivatives

Publications (1)

Publication Number Publication Date
GB1582234A true GB1582234A (en) 1981-01-07

Family

ID=10362573

Family Applications (1)

Application Number Title Priority Date Filing Date
GB34195/76A Expired GB1582234A (en) 1976-08-17 1976-08-17 Morphine derivatives

Country Status (14)

Country Link
US (1) US4140687A (en:Method)
JP (1) JPS5323998A (en:Method)
AU (1) AU517187B2 (en:Method)
BE (1) BE857753A (en:Method)
CA (1) CA1085834A (en:Method)
DE (1) DE2736260A1 (en:Method)
FR (1) FR2362144A1 (en:Method)
GB (1) GB1582234A (en:Method)
HU (1) HU176841B (en:Method)
IL (1) IL52632A (en:Method)
NL (1) NL7709024A (en:Method)
NO (1) NO772852L (en:Method)
PL (1) PL104043B1 (en:Method)
YU (1) YU40008B (en:Method)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101198612A (zh) * 2005-06-16 2008-06-11 马林克罗特公司 通过1-卤代-蒂巴因或类似物制备14-羟基阿片类的合成路线

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3112323A (en) * 1963-11-26 Method for the preparation of
US2778832A (en) * 1954-06-22 1957-01-22 Merck & Co Inc Reduction of codeinone to codeine
FR1282642A (fr) * 1960-12-13 1962-01-27 S E M P A Préparation de la codéine et de composés apparentés
FR1290174A (fr) 1961-01-25 1962-04-13 S E M P A Chemie Préparation de la codéïnone à partir de la thébaïne
ES427722A1 (es) 1974-06-24 1976-08-01 Quim Fab De Prod Metodo para la preparacion de codeinona a partir de tebai- na.
GB1472397A (en) 1976-02-23 1977-05-04 Prod Quimicos Y Farmaceuticos Method of preparing codeinone from thebaine
FR2342288A1 (fr) * 1976-02-26 1977-09-23 Quimicos Farma Fab Prod Procede pour la preparation de codeinone a partir de thebaine
US4054566A (en) * 1976-03-10 1977-10-18 The Regents Of The University Of California Process for converting neopinone to codeinone
US4052402A (en) * 1976-03-15 1977-10-04 Fabrica De Productos Quimicos Y Farmaceuticos Abello, S.A. Process for synthesizing codeinone from thebaine

Also Published As

Publication number Publication date
HU176841B (en) 1981-05-28
YU40008B (en) 1985-06-30
YU194877A (en) 1983-01-21
CA1085834A (en) 1980-09-16
FR2362144B1 (en:Method) 1983-01-28
IL52632A (en) 1980-02-29
NO772852L (no) 1978-02-20
US4140687A (en) 1979-02-20
BE857753A (fr) 1978-02-13
JPS6312872B2 (en:Method) 1988-03-23
PL200323A1 (pl) 1978-05-08
PL104043B1 (pl) 1979-07-31
AU2754977A (en) 1979-02-08
FR2362144A1 (fr) 1978-03-17
JPS5323998A (en) 1978-03-06
IL52632A0 (en) 1977-10-31
AU517187B2 (en) 1981-07-16
DE2736260A1 (de) 1978-02-23
NL7709024A (nl) 1978-02-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee