GB1565492A - Apparatus and method for measuring white blood cell platelet cncentrations in blood - Google Patents
Apparatus and method for measuring white blood cell platelet cncentrations in blood Download PDFInfo
- Publication number
- GB1565492A GB1565492A GB11753/78A GB1175378A GB1565492A GB 1565492 A GB1565492 A GB 1565492A GB 11753/78 A GB11753/78 A GB 11753/78A GB 1175378 A GB1175378 A GB 1175378A GB 1565492 A GB1565492 A GB 1565492A
- Authority
- GB
- United Kingdom
- Prior art keywords
- capillary tube
- cell
- light
- cell layer
- measured
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004369 blood Anatomy 0.000 title claims description 24
- 239000008280 blood Substances 0.000 title claims description 24
- 238000000034 method Methods 0.000 title claims description 16
- 210000001772 blood platelet Anatomy 0.000 title description 8
- 210000000265 leukocyte Anatomy 0.000 title description 4
- 210000004027 cell Anatomy 0.000 claims description 77
- 239000000470 constituent Substances 0.000 claims description 11
- 230000003287 optical effect Effects 0.000 claims description 10
- 210000000601 blood cell Anatomy 0.000 claims description 6
- 239000007850 fluorescent dye Substances 0.000 claims description 6
- 238000012856 packing Methods 0.000 claims description 3
- 238000012935 Averaging Methods 0.000 claims description 2
- 238000004040 coloring Methods 0.000 claims description 2
- 238000010186 staining Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims 2
- 238000009987 spinning Methods 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 11
- 230000005499 meniscus Effects 0.000 description 11
- 210000003714 granulocyte Anatomy 0.000 description 10
- 230000000881 depressing effect Effects 0.000 description 5
- 230000000994 depressogenic effect Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 210000005087 mononuclear cell Anatomy 0.000 description 3
- 238000004820 blood count Methods 0.000 description 2
- 239000013536 elastomeric material Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
- DPKHZNPWBDQZCN-UHFFFAOYSA-N acridine orange free base Chemical compound C1=CC(N(C)C)=CC2=NC3=CC(N(C)C)=CC=C3C=C21 DPKHZNPWBDQZCN-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000012505 colouration Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 201000006747 infectious mononucleosis Diseases 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/042—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates
- G01N2015/045—Investigating sedimentation of particle suspensions by centrifuging and investigating centrifugates by optical analysis
Landscapes
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/788,509 US4156570A (en) | 1977-04-18 | 1977-04-18 | Apparatus and method for measuring white blood cell and platelet concentrations in blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1565492A true GB1565492A (en) | 1980-04-23 |
Family
ID=25144711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB11753/78A Expired GB1565492A (en) | 1977-04-18 | 1978-03-23 | Apparatus and method for measuring white blood cell platelet cncentrations in blood |
Country Status (7)
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390283A (en) * | 1979-09-04 | 1983-06-28 | Beckman Instruments, Inc. | Magnetic strirrer for sample container |
| US4558947A (en) * | 1983-11-07 | 1985-12-17 | Wardlaw Stephen C | Method and apparatus for measuring blood constituent counts |
| US4567754A (en) * | 1985-03-29 | 1986-02-04 | Wardlaw Stephen C | Measurement of small heavy constituent layer in stratified mixture |
| JPH06100596B2 (ja) * | 1986-09-10 | 1994-12-12 | 東亜医用電子株式会社 | フロ−サイトメトリ−による白血球の分類方法 |
| US4828716A (en) * | 1987-04-03 | 1989-05-09 | Andronic Devices, Ltd. | Apparatus and method for separating phases of blood |
| US5030341A (en) * | 1987-04-03 | 1991-07-09 | Andronic Technologies, Inc. | Apparatus for separating phases of blood |
| US4779976A (en) * | 1987-08-31 | 1988-10-25 | Levine Robert A | Multiparameter hematology measurement for veterinarians |
| WO1989006803A1 (en) * | 1988-01-14 | 1989-07-27 | Nordisk Gentofte A/S | Apparatus for determination of the coagulation time of a blood sample |
| US4843869A (en) * | 1988-03-21 | 1989-07-04 | Levine Robert A | Method for measuring hemoglobin |
| JP2501460B2 (ja) * | 1988-03-23 | 1996-05-29 | オリンパス光学工業株式会社 | ヘマトクリット値の測定方法 |
| US4887458A (en) * | 1988-09-21 | 1989-12-19 | Separation Techology, Inc. | Hematocrit reader apparatus and method |
| US5239360A (en) * | 1988-10-21 | 1993-08-24 | Applied Biosystems, Inc. | Lens for capillary electrophoresis and chromatography |
| US5089384A (en) * | 1988-11-04 | 1992-02-18 | Amoco Corporation | Method and apparatus for selective cell destruction using amplified immunofluorescence |
| US5132087A (en) * | 1989-10-16 | 1992-07-21 | Kristen L Manion | Apparatus for measuring blood constituent counts |
| US5506145A (en) * | 1994-12-02 | 1996-04-09 | Bull; Brian S. | Determination of an individual's inflammation index from whole blood fibrinogen and hematocrit or hemoglobin measurements |
| GB9606559D0 (en) * | 1996-03-28 | 1996-06-05 | Zynocyte Ltd | Apparatus and method for analysing blood samples |
| US6152868A (en) * | 1998-03-02 | 2000-11-28 | Becton, Dickinson And Company | Inertial tube indexer |
| US5888184A (en) * | 1997-03-10 | 1999-03-30 | Robert A. Levine | Method for rapid measurement of cell layers |
| CA2230222A1 (en) * | 1997-03-10 | 1998-09-10 | Stephen C. Wardlaw | Method and assembly for rapid measurement of cell layers |
| US5811303A (en) * | 1997-04-01 | 1998-09-22 | Streck Laboratories, Inc. | Quantitative buffy coat control composition |
| US6197523B1 (en) * | 1997-11-24 | 2001-03-06 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood |
| US6911315B2 (en) * | 1997-11-24 | 2005-06-28 | David L. Rimm | Method for the detection, identification, enumeration and confirmation of virally infected cells and other epitopically defined cells in whole blood |
| US6080366A (en) * | 1998-03-02 | 2000-06-27 | Becton, Dickinson And Company | Disposable blood tube holder |
| US6030086A (en) * | 1998-03-02 | 2000-02-29 | Becton, Dickinson And Company | Flash tube reflector with arc guide |
| US6074883A (en) * | 1998-03-02 | 2000-06-13 | Becton, Dickinson And Company | Method for using disposable blood tube holder |
| US6002474A (en) * | 1998-03-02 | 1999-12-14 | Becton Dickinson And Company | Method for using blood centrifugation device with movable optical reader |
| US6285450B1 (en) | 1998-03-02 | 2001-09-04 | Bradley S. Thomas | Blood centrifugation device with movable optical reader |
| US6120429A (en) * | 1998-03-02 | 2000-09-19 | Becton, Dickinson And Company | Method of using inertial tube indexer |
| US6153148A (en) * | 1998-06-15 | 2000-11-28 | Becton, Dickinson And Company | Centrifugal hematology disposable |
| EP2278383A1 (en) * | 2004-11-24 | 2011-01-26 | Battelle Memorial Institute | A test tube handling apparatus |
| SE528697C2 (sv) * | 2005-03-11 | 2007-01-30 | Hemocue Ab | Volymetrisk bestämning av antalet vita blodkroppar i ett blodprov |
| US7998696B2 (en) * | 2007-12-05 | 2011-08-16 | Zyomyx, Inc. | Cell assay kit and method |
| US8988881B2 (en) | 2007-12-18 | 2015-03-24 | Sandia Corporation | Heat exchanger device and method for heat removal or transfer |
| EP2249701B1 (en) | 2008-03-05 | 2020-04-29 | Becton, Dickinson and Company | Capillary action collection container assembly |
| US9005417B1 (en) | 2008-10-01 | 2015-04-14 | Sandia Corporation | Devices, systems, and methods for microscale isoelectric fractionation |
| US20110178424A1 (en) | 2010-01-19 | 2011-07-21 | Becton, Dickinson And Company | Specimen Collection Container Having a Transitional Fill-Volume Indicator Indicating Extraction Method |
| US9186668B1 (en) | 2010-06-04 | 2015-11-17 | Sandia Corporation | Microfluidic devices, systems, and methods for quantifying particles using centrifugal force |
| US8962346B2 (en) | 2010-07-08 | 2015-02-24 | Sandia Corporation | Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation |
| US8945914B1 (en) | 2010-07-08 | 2015-02-03 | Sandia Corporation | Devices, systems, and methods for conducting sandwich assays using sedimentation |
| US9795961B1 (en) | 2010-07-08 | 2017-10-24 | National Technology & Engineering Solutions Of Sandia, Llc | Devices, systems, and methods for detecting nucleic acids using sedimentation |
| US9261100B2 (en) | 2010-08-13 | 2016-02-16 | Sandia Corporation | Axial flow heat exchanger devices and methods for heat transfer using axial flow devices |
| US8460620B2 (en) | 2010-12-03 | 2013-06-11 | Becton, Dickinson And Company | Specimen collection container assembly |
| US9244065B1 (en) | 2012-03-16 | 2016-01-26 | Sandia Corporation | Systems, devices, and methods for agglutination assays using sedimentation |
| US9903001B1 (en) | 2012-07-19 | 2018-02-27 | National Technology & Engineering Solutions Of Sandia, Llc | Quantitative detection of pathogens in centrifugal microfluidic disks |
| WO2014074737A1 (en) | 2012-11-07 | 2014-05-15 | Sandstone Diagnostics, Inc. | Methods and devices for processing samples and counting cells |
| US10197480B2 (en) | 2012-11-07 | 2019-02-05 | Sandstone Diagnostics, Inc. | Methods and devices for processing samples and counting cells |
| US9304128B1 (en) | 2013-02-01 | 2016-04-05 | Sandia Corporation | Toxin activity assays, devices, methods and systems therefor |
| WO2014124179A1 (en) | 2013-02-07 | 2014-08-14 | Sandstone Diagnostics, Inc. | Automated sample processing, fluid distribution, and sedimentation assay |
| US9500579B1 (en) | 2013-05-01 | 2016-11-22 | Sandia Corporation | System and method for detecting components of a mixture including tooth elements for alignment |
| CN103529230B (zh) * | 2013-10-23 | 2015-07-29 | 北京倍肯恒业科技发展有限责任公司 | 一种干式血液细胞分析装置 |
| CN103558403A (zh) * | 2013-10-23 | 2014-02-05 | 北京倍肯恒业科技发展有限责任公司 | 一种干式血液细胞分析装置的主控数据处理系统 |
| CN103528936B (zh) * | 2013-10-23 | 2016-05-18 | 北京倍肯恒业科技发展股份有限公司 | 一种干式血液细胞分析装置的光学检测系统 |
| CN103529231B (zh) * | 2013-10-23 | 2016-01-13 | 北京倍肯恒业科技发展有限责任公司 | 一种干式血液细胞分析装置的机械进样系统 |
| US9803238B1 (en) | 2013-11-26 | 2017-10-31 | National Technology & Engineering Solutions Of Sandia, Llc | Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid |
| US9702871B1 (en) | 2014-11-18 | 2017-07-11 | National Technology & Engineering Solutions Of Sandia, Llc | System and method for detecting components of a mixture including a valving scheme for competition assays |
| US10254298B1 (en) | 2015-03-25 | 2019-04-09 | National Technology & Engineering Solutions Of Sandia, Llc | Detection of metabolites for controlled substances |
| KR101701334B1 (ko) * | 2015-11-24 | 2017-02-13 | 전북대학교산학협력단 | 포터블 혈액점도측정장치 |
| US10406528B1 (en) | 2016-08-04 | 2019-09-10 | National Technology & Engineering Solutions Of Sandia, Llc | Non-contact temperature control system for microfluidic devices |
| US10981174B1 (en) | 2016-08-04 | 2021-04-20 | National Technology & Engineering Solutions Of Sandia, Llc | Protein and nucleic acid detection for microfluidic devices |
| US10786811B1 (en) | 2016-10-24 | 2020-09-29 | National Technology & Engineering Solutions Of Sandia, Llc | Detection of active and latent infections with microfluidic devices and systems thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2840915A (en) * | 1954-03-23 | 1958-07-01 | Louis E Drummond | Apparatus for determining the percentage of red cells in a blood specimen |
| US2973580A (en) * | 1958-09-24 | 1961-03-07 | American Optical Corp | Apparatus for use in analyzing blood |
| US3561877A (en) * | 1967-06-30 | 1971-02-09 | Delta Research Inc | Hematocrit reader |
| US3582218A (en) * | 1969-10-17 | 1971-06-01 | Atomic Energy Commission | Multistation photometric analyzer |
| NL169367C (nl) * | 1970-12-09 | 1982-07-01 | Lode S Instr N V | Werkwijze en inrichting voor het bepalen van de coagulatietijd van bloed. |
| US3916205A (en) * | 1973-05-31 | 1975-10-28 | Block Engineering | Differential counting of leukocytes and other cells |
| US3914985A (en) * | 1974-03-29 | 1975-10-28 | American Hospital Supply Corp | Centrifuging device and method |
| US4031399A (en) * | 1975-02-24 | 1977-06-21 | Beckman Instruments, Inc. | Fluorometer |
| US4054387A (en) * | 1975-12-22 | 1977-10-18 | Vickers Instruments, Inc. | Measuring with microscope |
| US4027660A (en) * | 1976-04-02 | 1977-06-07 | Wardlaw Stephen C | Material layer volume determination |
-
1977
- 1977-04-18 US US05/788,509 patent/US4156570A/en not_active Expired - Lifetime
-
1978
- 1978-03-23 GB GB11753/78A patent/GB1565492A/en not_active Expired
- 1978-04-12 IT IT48875/78A patent/IT1102583B/it active
- 1978-04-17 JP JP4515478A patent/JPS53129485A/ja active Granted
- 1978-04-17 SU SU782605501A patent/SU940656A3/ru active
- 1978-04-18 DE DE2816870A patent/DE2816870C2/de not_active Expired
- 1978-04-18 FR FR7811372A patent/FR2388277A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| US4156570A (en) | 1979-05-29 |
| DE2816870C2 (de) | 1987-04-23 |
| JPS53129485A (en) | 1978-11-11 |
| FR2388277A1 (fr) | 1978-11-17 |
| IT1102583B (it) | 1985-10-07 |
| DE2816870A1 (de) | 1978-10-26 |
| SU940656A3 (ru) | 1982-06-30 |
| FR2388277B1 (US07923587-20110412-C00001.png) | 1982-04-16 |
| IT7848875A0 (it) | 1978-04-12 |
| JPS6139620B2 (US07923587-20110412-C00001.png) | 1986-09-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19980322 |