GB1563284A - Production of mutant of aujeszky's virus - Google Patents
Production of mutant of aujeszky's virus Download PDFInfo
- Publication number
- GB1563284A GB1563284A GB27522/77A GB2752277A GB1563284A GB 1563284 A GB1563284 A GB 1563284A GB 27522/77 A GB27522/77 A GB 27522/77A GB 2752277 A GB2752277 A GB 2752277A GB 1563284 A GB1563284 A GB 1563284A
- Authority
- GB
- United Kingdom
- Prior art keywords
- virus
- aujeszky
- mutant
- desoxyuridine
- iodo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 241000700605 Viruses Species 0.000 title description 37
- 238000004519 manufacturing process Methods 0.000 title description 6
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 13
- 238000000034 method Methods 0.000 description 11
- 230000003612 virological effect Effects 0.000 description 9
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical group O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 7
- 230000000340 anti-metabolite Effects 0.000 description 7
- 229940100197 antimetabolite Drugs 0.000 description 7
- 239000002256 antimetabolite Substances 0.000 description 7
- 230000002068 genetic effect Effects 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 230000002163 immunogen Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 229960005486 vaccine Drugs 0.000 description 5
- 229920001817 Agar Polymers 0.000 description 4
- 239000008272 agar Substances 0.000 description 4
- 230000004075 alteration Effects 0.000 description 4
- 244000309466 calf Species 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 102000039446 nucleic acids Human genes 0.000 description 3
- 108020004707 nucleic acids Proteins 0.000 description 3
- 150000007523 nucleic acids Chemical class 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
- 241000282472 Canis lupus familiaris Species 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- 230000017613 viral reproduction Effects 0.000 description 2
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical class C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 description 1
- 241000450599 DNA viruses Species 0.000 description 1
- 206010064571 Gene mutation Diseases 0.000 description 1
- 102000004407 Lactalbumin Human genes 0.000 description 1
- 108090000942 Lactalbumin Proteins 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 210000001726 chromosome structure Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/245—Herpetoviridae, e.g. herpes simplex virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
- C12N2710/16761—Methods of inactivation or attenuation
- C12N2710/16763—Methods of inactivation or attenuation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BG3365276 | 1976-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1563284A true GB1563284A (en) | 1980-03-26 |
Family
ID=3902412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27522/77A Expired GB1563284A (en) | 1976-07-02 | 1977-06-30 | Production of mutant of aujeszky's virus |
Country Status (7)
| Country | Link |
|---|---|
| AR (1) | AR216081A1 (enExample) |
| BE (1) | BE856351A (enExample) |
| CA (1) | CA1069821A (enExample) |
| ES (1) | ES460321A1 (enExample) |
| FR (1) | FR2356726A1 (enExample) |
| GB (1) | GB1563284A (enExample) |
| NL (1) | NL7707341A (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3122669A1 (de) * | 1980-06-12 | 1982-02-11 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | "verfahren zur herstellung von neuen mutanten von herpes simplex-viren typ 1 und typ 2" |
| HU187421B (en) * | 1982-10-27 | 1986-01-28 | Phylaxia Oltoanyagtermeloe Vallalat,Hu | Process for producing inactivated, adjuvated serum against aujeszky's illness |
| US4514497B1 (en) * | 1983-12-30 | 1998-02-24 | Novagene Inc | Modified live pseudorabies viruses |
-
1977
- 1977-06-29 AR AR268231A patent/AR216081A1/es active
- 1977-06-30 GB GB27522/77A patent/GB1563284A/en not_active Expired
- 1977-06-30 CA CA281,836A patent/CA1069821A/en not_active Expired
- 1977-07-01 NL NL7707341A patent/NL7707341A/xx not_active Application Discontinuation
- 1977-07-01 FR FR7720399A patent/FR2356726A1/fr active Granted
- 1977-07-01 ES ES460321A patent/ES460321A1/es not_active Expired
- 1977-07-01 BE BE2056044A patent/BE856351A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL7707341A (nl) | 1978-01-04 |
| CA1069821A (en) | 1980-01-15 |
| BE856351A (fr) | 1977-10-31 |
| FR2356726B1 (enExample) | 1981-01-16 |
| AR216081A1 (es) | 1979-11-30 |
| FR2356726A1 (fr) | 1978-01-27 |
| ES460321A1 (es) | 1978-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Sager | Cytoplasmic genes and organelles | |
| Yaffe | Cellular aspects of muscle differentiation in vitro | |
| US6303568B1 (en) | Therapeutic antimicrobial polypeptides, their use and methods for preparation | |
| Coleman et al. | A clonal study of the reversible inhibition of muscle differentiation by the halogenated thymidine analog 5-bromodeoxyuridine | |
| Gardner | The use of tricine buffer in animal tissue cultures | |
| Bonami et al. | Rickettsial infection in marine crustacea | |
| KR860000900B1 (ko) | 인체 황체형성 호르몬의 제조방법 | |
| Jeon et al. | Temperature sensitivity: a cell character determined by obligate endosymbionts in amoebas | |
| US4169761A (en) | Process for the cultivation of viruses | |
| Müller et al. | Morphogenetic factors in hydroids: I. Stolon tip activation and inhibition | |
| Sonnenschein et al. | Loss of growth hormone production following hybridization of a functional rat pituitary cell strain with a mouse fibroblast line | |
| GB1563284A (en) | Production of mutant of aujeszky's virus | |
| JP4267689B2 (ja) | 鳥類由来の細胞の培養方法および該培養方法によって得られた細胞系 | |
| US3616203A (en) | Virus culture and method | |
| RU2106879C1 (ru) | Способ культивирования медленнорастущих микобактерий | |
| RU2085584C1 (ru) | Способ получения рекомбинантных туляремийных микроорганизмов - продуцентов факторов вирулентности, рекомбинантный штамм francisella tularensis subspecies, holarctica r5s - продуцент фактора вирулентности francisella tularensis nearctica shu, рекомбинантный штамм francisella tularensis holarctica rn4 - продуцент фактора вирулентности pseudomonas pseudomallei c 141, рекомбинантный штамм francisella tularensis subspecies holarctica r1a - продуцент фактора вирулентности francisella tularensis nearctica b 399 a cole | |
| WO1982003408A1 (fr) | Procede de preparation d'un adn-hybride, contenant le genome complementaire du virus de l'hepatite a, l'adn-hybride lui-meme, le vecteur plasmidique le contenant, les proteines specifiques du virus codees par l'adn-hybride et des vaccins les contenant | |
| Gibson et al. | Extranuclear DNA and the endosymbionts of Paramecium aurelia | |
| SU1659474A1 (ru) | Способ культивировани ооцитов коров | |
| Volpe et al. | Somatic cell mating and segregation in chimeric frogs | |
| RU2067995C1 (ru) | Способ получения культур клеток | |
| Mukherjee et al. | Mammalian cell culture: an overview | |
| Klebe | Genetic mapping of a human regulator gene | |
| Sandle et al. | Fundamentals of cell culture | |
| RU2209829C2 (ru) | Способ культивирования микроорганизмов mycobacterium tuberculosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |