GB1562643A - Method of and apparatus for applying cover-slips to slidescarrying specimens for microscopic examination - Google Patents
Method of and apparatus for applying cover-slips to slidescarrying specimens for microscopic examination Download PDFInfo
- Publication number
- GB1562643A GB1562643A GB811177A GB811177A GB1562643A GB 1562643 A GB1562643 A GB 1562643A GB 811177 A GB811177 A GB 811177A GB 811177 A GB811177 A GB 811177A GB 1562643 A GB1562643 A GB 1562643A
- Authority
- GB
- United Kingdom
- Prior art keywords
- slide
- cover
- slip
- solvent
- nozzle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 16
- 239000002904 solvent Substances 0.000 claims description 47
- 239000011248 coating agent Substances 0.000 claims description 17
- 238000000576 coating method Methods 0.000 claims description 17
- 239000010410 layer Substances 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 11
- 230000001070 adhesive effect Effects 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 10
- 229920003023 plastic Polymers 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 239000012790 adhesive layer Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- 238000000151 deposition Methods 0.000 claims description 2
- 238000012840 feeding operation Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims description 2
- 239000004033 plastic Substances 0.000 description 4
- 239000011888 foil Substances 0.000 description 3
- 239000006059 cover glass Substances 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
- B29C66/47—Joining single elements to sheets, plates or other substantially flat surfaces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4805—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the type of adhesives
- B29C65/481—Non-reactive adhesives, e.g. physically hardening adhesives
- B29C65/482—Drying adhesives, e.g. solvent based adhesives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/4895—Solvent bonding, i.e. the surfaces of the parts to be joined being treated with solvents, swelling or softening agents, without adhesives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
- B29C65/48—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding
- B29C65/52—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive
- B29C65/524—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor using adhesives, i.e. using supplementary joining material; solvent bonding characterised by the way of applying the adhesive by applying the adhesive from an outlet device in contact with, or almost in contact with, the surface of the part to be joined
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/01—General aspects dealing with the joint area or with the area to be joined
- B29C66/05—Particular design of joint configurations
- B29C66/10—Particular design of joint configurations particular design of the joint cross-sections
- B29C66/11—Joint cross-sections comprising a single joint-segment, i.e. one of the parts to be joined comprising a single joint-segment in the joint cross-section
- B29C66/112—Single lapped joints
- B29C66/1122—Single lap to lap joints, i.e. overlap joints
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/40—General aspects of joining substantially flat articles, e.g. plates, sheets or web-like materials; Making flat seams in tubular or hollow articles; Joining single elements to substantially flat surfaces
- B29C66/47—Joining single elements to sheets, plates or other substantially flat surfaces
- B29C66/472—Joining single elements to sheets, plates or other substantially flat surfaces said single elements being substantially flat
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C66/00—General aspects of processes or apparatus for joining preformed parts
- B29C66/80—General aspects of machine operations or constructions and parts thereof
- B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
- B29C66/834—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools moving with the parts to be joined
- B29C66/8341—Roller, cylinder or drum types; Band or belt types; Ball types
- B29C66/83431—Roller, cylinder or drum types; Band or belt types; Ball types rollers, cylinders or drums cooperating with bands or belts
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
Description
(54) METHOD OF AND APPARATUS FOR APPLYING COVER-SLIPS
TO SLIDES CARRYING SPECIMENS FOR
MICROSCOPIC EXAMINATION
(71) We, CYTOLOGISKA CEN
TRALLABORATORIET AB, A Swedish
Body Corporate of, Box 20047, S-20074
Malmo 20, Sweden, do hereby declare the invention for which we pray that a Patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement:
The present invention relates to a method of and apparatus for applying cover-slips to slides carrying specimens for microscopic examination.
Slides are used for instance in pathology and cytology for the microscopy of sections and smears from different types of members and tissues, the speciments being deposited on said slides in very thin sections or in the form of smears. The slides are subsequently coloured in different manners, and then provided with a cover-slip or cover-glass, which is, by means of a transparent mounting, attached on the top of the specimen.
Covers of a liquid plastics have been used, which after drying solidify into a transparent layer. If a cover-glass or a plastics coating is used, it must be transparent and possess the optical properties necessary for microscopy with transmitted light, and it also serves as a protective layer for the specimen.
Cover layers or cover-slips, are at present always applied manually. While attempts have been made to make this work more or less mechanical, this has so far been impossible to achieve in an efficient and practical way. Among the difficulties are that the specimens deposited on the slides must not, during the application of the cover-plate, come into contact with extraneous mechanical parts and that the mounting of the cover-slip has to be carried out so as to avoid totally any air inclusions beneath the same.
According to the present invention there is provided a method of mechanically applying cover-slips onto slides bearing specimens for microscopic examination, wherein the slides are fed consecutively to a coating station at which a solvent film is applied to each slide from a nozzle which spreads the film of solvent over the slide during movement of the slide therebeneath, the nozzle being sufficiently spaced from the slide during such movement as to avoid contact with the specimen thereon, and each slide is then fed to an application station where the cover-slips, which are flexible and each have a dry adhesive layer on the side thereof arranged to bear against the solvent film on the slide, are applied to the slides, each cover slip being applied to an associated slide progressively from one end as the slide is advanced in order to squeeze any excess solvent and air from between the cover slip and slide during such application.
It has been found that cover slips can be applied in this way without the formation of air inclusions.
Previously adhesive coated foils may be used as cover-slips. It is, of course, preferred and expected that the adhesive will not be tacky until contacted by the solvent which has the primary purpose of activating the adhesive.
The solvent film is applied to the slides and spread by means of a nozzle, which does not come into contact with the specimens, a solvent "bridge" or layer being maintained between the nozzle and the slide and specimen.
A transparent plastics material in the form of a roll may conveniently be used for the cover-slips, the side of the ribbon arranged to contact the solvent layer being previously provided with the adhesive coating, the adhesive capacity of which is only initiated when the coating comes into contact with said solvent layer. Cover-slips can then be successively severed from the endless ribbon at the time of their application.
During cover-slip application, each coverslip is depressed so as to have one end at an angle to the slide this forming a solvent excess in the apex between slide and slip.
The cover-slip can then be flattened gradually towards the opposite end of the cover-slip while maintaining the solvent excess in the apex.
The invention also provides apparatus for the application of cover-slips onto slides provided with specimens for microscopic examination, such apparatus comprising a coating station, an application station and a conveyor for feeding slides in succession to and through the said stations, the coating station comprising a nozzle arranged to dispense and spread solvent onto a slide during use of the apparatus while so spaced from the slide as not to contact a specimen on the slide as the conveyor carries the slide beneath the nozzle and the application station comprising means for applying an adhesive covered side of a flexible cover slip progressively from one end onto a slide as the slide is carried forward by the conveyor whereby any excess solvent and air is squeezed from between the cover-slip and slide.
The invention will be more clearly understood from the following description which is given by way of example with reference to the accompanying drawings, in which:
Figure 1 is a side view of apparatus according to the invention;
Figures 2 and 3 show partial enlargements of the nozzle which acts as a spreading member;
Figure 4 shows a detail of the application of the cover-slip to a slide: and
Figure 5 is a plan view of a slide provided with a cover-slip.
In Figure 1 a ribbon of a plastics foil is wound up on a supply spool 2 and has an adhesive coating on the side designed to be brought to bear against the slide. This coating is provided in advance on the plastics foil, and dried to remove solvent prior to being wound, so as to make it possible to wind up the ribbon onto a spool without risk of adjacent turns adhering to one another.
The ribbon 2 is passed over a number of guide rollers to a first driving roller 4, and from there via a severing station 9 to a second driving roller 5. The rollers 4, 5 are driven by belt drive 8 from a master shaft 6.
Slides 7 on which specimens have been placed are fed synchronously simultaneously with operation of the belt drive by a chain conveyor in an essentially horizontal path from a station 7a, and they then pass a
coating station 7b for solvent comprising a solvent container 10, which is connected by
a feeder tube 16 to a nozzle which acts as a
spreading member 11. At a slip applying station 7c a roller 12 is provided for the application of the cover-slips to the slides.
The apparatus also includes a starting device 13 and a braking mechanism 14, 15.
A cover-slip applied to the slide 7 is indicated at 22 in Figure 5. The cover-slip 22 and the slide 7 are, in application, fed at the same velocity, but since the cover-slip 22 is shorter than the slide and as a certain space exists between two subsequent slides 7 on the conveyor 8, the length of the cover-slip fed in a given time is reduced by means of discontinuities in the driving rollers 4 and 5.
Solvent is hermetically enclosed in the container 10, which has a connection to the exterior only through the feeder tube 16.
Tube 16 is at its lower end provided with a
V-shaped nozzle 11 with a slit opening or a series of apertures across its bottom. The spreading nozzle 11 shaped in this manner is of an appropriate width with respect to the slide. The distance h from the mouth of the feeder tube 16 to the tip of the spreading nozzle 11 is adjusted so as to make the surface tension of the solvent resist the pressure of the column of liquid h when the dispensing nozzle hangs freely in the air.
This implies of course, that the solvent cannot drop from the nozzle.
The device shown in the drawing operates in the following manner: When a slide 7 has been deposited on the belt conveyor at the position 7a the machine will start, whereby the slide 7 is fed along by the conveyor into the position 7b by reason of a cam 14 being rotated one revolution, after which it will temporarily interrupt the feeding movement of the conveyor. When a new slide 7 is supplied to the conveyor at the position 7a, the previous slide will be fed from the position 7b to the position 7c and during this process will be coated with solvent layer in the following manner. At the position 7b as shown in an enlarged scale in Figure 2, the spreading or dispensing nozzle 11 is lowered against the leading end of the now stationary slide, said end being free of the specimen. When the dispensing nozzle contacts the slide a small liquid excess swelling 17 will form, but will be restricted owing to the surface tension. When the slide 7 is then fed along, as indicated by Figure 3, the dispensing nozzle 11 is somewhat raised from the slide so as to be able to dispense and spread a film of solvent onto the slide during such slide feeding movement, the raising being such that the nozzle will thus not come into contact with the specimen. During this movement a liquid film 18 is formed on the slide and spread out from the nozzle over the slide. When the column of liquid h sinks, air can be supplied through the mouth in the feeder tube 16, whereupon new liquid flows down into the nozzle. Immediately before the opposite end of the slide passes the nozzle 11, the nozzle is raised, whereby the application of the liquid film 18 is interrupted.
At the same time as the slides 7 are transferred along on the conveyor the ribbon 2 is fed into a position 19 between rollers 4 and 5, and where a cover strip of a convenient length is severed by means of the device 9.
As the slide 7 reaches the position 7c, a coverslip of appropriate length is simultaneously fed along into the position 19. At the next feeding operation, the cover-slip will, by means of the feeding rollers 5, be fed down to the roller 12 (see in this connection Figure 4). In the angle between the cover-slip and the slide a swelling or excess 20 of solvent will form. Thereafter the slide moves relative to the roller 12 so that the cover-slip is pressed down over the length of the slide. The excess 20 of solvent will be pushed along and by this the air is prevented from getting admission, so that the film 21 forming between the cover-slip and the slide will be quite free from air bubbles. The roller 12 is accordingly positioned at a certain distance from the slide, so that a liquid film will at all times remain between the cover slip and the preparation.
The slide thus provided with a cover-slip will then leave the machine by a chute 23 and may then be placed in a drying rack with step-by-step feeding. The entire system can of course be made fully automatic for the depositing as well as the removal of the slides.
WHAT WE CLAIM IS:
1. A method of mechanically applying coverslips onto slides bearing specimens for microscopic examination, wherein the slides are fed consecutively to a coating station at which a solvent film is applied to each slide from a nozzle which spreads the film of solvent over the slide during movement of the slide therebeneath, the nozzle being sufficiently spaced from the slide during such movement as to avoid contact with the specimen thereon, and each slide is then fed to an application station where the coverslips, which are flexible and each have a dry adhesive layer on the side thereof arranged to bear against the solvent film on the slide, are applied to the slides, each cover-slip being applied to an associated slide progressively from one end as the slide is advanced in order to squeeze any excess solvent and air from between the cover-slip and the slide during such application.
2. A method according to claim 1, wherein each cover-slip is, during its application to the slide, pressed towards the side at one end so as to make an angle with the slide, and then flattened towards the solvent layer as the slide and cover slip are advanced beneath a roller which presses the cover slip towards the slide.
3. A method according to claim 1 or 2, wherein the cover-slips are, before being applied to the slides, successively severed from a ribbon of transparent plastics material one side of which has been precoated with an adhesive to be activated by the solvent layer.
4. A method according to any preceding claim where the nozzle is first lowered against the leading end of the slide before being raised therefrom during the movement of the slide beneath the nozzle as the nozzle applies and spreads the film of solvent over the slide.
5. Apparatus for the application of coverslips onto slides provided with specimens for microscopic examination, such apparatus comprising a coating station, an application station and a conveyor for feeding slides in succession to and through the said stations, the coating station comprising a nozzle arranged to dispense and spread solvent onto a slide during use of the apparatus while so spaced from the slide as not to contact a specimen on the slide as the conveyor carries the slide beneath the nozzle and the application station comprising means for applying an adhesive covered side of a flexible cover-slip progressively from one end onto a slide as the slide is carried forward by the conveyor whereby any excess solvent and air is squeezed from between the coverslip and slide.
6. Apparatus according to claim 5, including, at the coating station, a feeder tube connected to a solvent container and leading to a spreading member comprised by the nozzle.
7. Apparatus according to claim 5 or 6, including in the application station a roller provided to depress the cover-slip against the solvent layer starting from one end of the slide.
8. A device according to claim 5, 6 or 7 including means for supporting a supply spool comprising a ribbon of cover-slip material, a severing means, and guide and drive rollers for feeding the ribbon into the severing means, one of said driving rollers being provided to feed severed cover-slips to the application means for application.
9. A method of mechanically applying cover-slips onto specimen carrying slides substantially as hereinbefore described with
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (10)
1. A method of mechanically applying coverslips onto slides bearing specimens for microscopic examination, wherein the slides are fed consecutively to a coating station at which a solvent film is applied to each slide from a nozzle which spreads the film of solvent over the slide during movement of the slide therebeneath, the nozzle being sufficiently spaced from the slide during such movement as to avoid contact with the specimen thereon, and each slide is then fed to an application station where the coverslips, which are flexible and each have a dry adhesive layer on the side thereof arranged to bear against the solvent film on the slide, are applied to the slides, each cover-slip being applied to an associated slide progressively from one end as the slide is advanced in order to squeeze any excess solvent and air from between the cover-slip and the slide during such application.
2. A method according to claim 1, wherein each cover-slip is, during its application to the slide, pressed towards the side at one end so as to make an angle with the slide, and then flattened towards the solvent layer as the slide and cover slip are advanced beneath a roller which presses the cover slip towards the slide.
3. A method according to claim 1 or 2, wherein the cover-slips are, before being applied to the slides, successively severed from a ribbon of transparent plastics material one side of which has been precoated with an adhesive to be activated by the solvent layer.
4. A method according to any preceding claim where the nozzle is first lowered against the leading end of the slide before being raised therefrom during the movement of the slide beneath the nozzle as the nozzle applies and spreads the film of solvent over the slide.
5. Apparatus for the application of coverslips onto slides provided with specimens for microscopic examination, such apparatus comprising a coating station, an application station and a conveyor for feeding slides in succession to and through the said stations, the coating station comprising a nozzle arranged to dispense and spread solvent onto a slide during use of the apparatus while so spaced from the slide as not to contact a specimen on the slide as the conveyor carries the slide beneath the nozzle and the application station comprising means for applying an adhesive covered side of a flexible cover-slip progressively from one end onto a slide as the slide is carried forward by the conveyor whereby any excess solvent and air is squeezed from between the coverslip and slide.
6. Apparatus according to claim 5, including, at the coating station, a feeder tube connected to a solvent container and leading to a spreading member comprised by the nozzle.
7. Apparatus according to claim 5 or 6, including in the application station a roller provided to depress the cover-slip against the solvent layer starting from one end of the slide.
8. A device according to claim 5, 6 or 7 including means for supporting a supply spool comprising a ribbon of cover-slip material, a severing means, and guide and drive rollers for feeding the ribbon into the severing means, one of said driving rollers being provided to feed severed cover-slips to the application means for application.
9. A method of mechanically applying cover-slips onto specimen carrying slides substantially as hereinbefore described with
reference to the accompanying drawings.
10. Apparatus for the application of cover-slips onto slides constructed and arranged to operate substantially as hereinbefore described with reference to and as illustrated in the accompanying drawings.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7602476A SE403940B (en) | 1976-02-26 | 1976-02-26 | SET AND DEVICE FOR MACHINE APPLICATION OF DRAWINGS ON WITH PREPARATIONS FOR MICROSCOPIC EXAMINATION FITTED SLIDES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1562643A true GB1562643A (en) | 1980-03-12 |
Family
ID=20327129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB811177A Expired GB1562643A (en) | 1976-02-26 | 1977-02-25 | Method of and apparatus for applying cover-slips to slidescarrying specimens for microscopic examination |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB1562643A (en) |
| SE (1) | SE403940B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000461A1 (en) * | 1995-06-15 | 1997-01-03 | Australian Biomedical Corporation Limited | Coverslip pick-up and laydown apparatus |
| AU701118B2 (en) * | 1995-06-15 | 1999-01-21 | Vision Instruments Limited | Coverslip pick-up and laydown apparatus |
| WO2005064309A1 (en) * | 2003-12-23 | 2005-07-14 | Ventana Medical Systems, Inc. | Method and apparatus for efficient thin film fluid |
| WO2005098393A1 (en) * | 2004-04-09 | 2005-10-20 | Sakura Seiki Co., Ltd. | Sticking device for cover film |
| US8911815B2 (en) | 2009-11-13 | 2014-12-16 | Ventana Medical Systems, Inc. | Thin film processing apparatuses for adjustable volume accommodation |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
-
1976
- 1976-02-26 SE SE7602476A patent/SE403940B/en not_active IP Right Cessation
-
1977
- 1977-02-25 GB GB811177A patent/GB1562643A/en not_active Expired
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997000461A1 (en) * | 1995-06-15 | 1997-01-03 | Australian Biomedical Corporation Limited | Coverslip pick-up and laydown apparatus |
| AU694049B2 (en) * | 1995-06-15 | 1998-07-09 | Vision Instruments Limited | Coverslip pick-up and laydown apparatus |
| AU701118B2 (en) * | 1995-06-15 | 1999-01-21 | Vision Instruments Limited | Coverslip pick-up and laydown apparatus |
| US5989386A (en) * | 1995-06-15 | 1999-11-23 | Vision Instruments Ltd. | Coverslip pick-up and laydown apparatus |
| US7615371B2 (en) | 2003-12-23 | 2009-11-10 | Ventana Medical Systems, Inc. | Method and apparatus for treating a biological sample with a liquid reagent |
| WO2005064309A1 (en) * | 2003-12-23 | 2005-07-14 | Ventana Medical Systems, Inc. | Method and apparatus for efficient thin film fluid |
| WO2005098393A1 (en) * | 2004-04-09 | 2005-10-20 | Sakura Seiki Co., Ltd. | Sticking device for cover film |
| US7748423B2 (en) | 2004-04-09 | 2010-07-06 | Sakura Seiki Co., Ltd. | Cover film sticking device |
| US8911815B2 (en) | 2009-11-13 | 2014-12-16 | Ventana Medical Systems, Inc. | Thin film processing apparatuses for adjustable volume accommodation |
| US9498791B2 (en) | 2009-11-13 | 2016-11-22 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US9618430B2 (en) | 2009-11-13 | 2017-04-11 | Ventana Medical Systems, Inc. | Thin film processing apparatuses for adjustable volume accommodation |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| USD728120S1 (en) | 2013-03-15 | 2015-04-28 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
| USD772424S1 (en) | 2013-03-15 | 2016-11-22 | Ventana Medical Systems, Inc. | Arcuate member for moving liquids along a microscope slide |
Also Published As
| Publication number | Publication date |
|---|---|
| SE403940B (en) | 1978-09-11 |
| SE7602476L (en) | 1977-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19970224 |