GB1559983A - Bis-(meta-amidinophenoxy)-compounds - Google Patents

Bis-(meta-amidinophenoxy)-compounds Download PDF

Info

Publication number
GB1559983A
GB1559983A GB39861/76A GB3986176A GB1559983A GB 1559983 A GB1559983 A GB 1559983A GB 39861/76 A GB39861/76 A GB 39861/76A GB 3986176 A GB3986176 A GB 3986176A GB 1559983 A GB1559983 A GB 1559983A
Authority
GB
United Kingdom
Prior art keywords
bis
amidinophenoxy
compound
meta
xylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB39861/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of GB1559983A publication Critical patent/GB1559983A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB39861/76A 1976-01-13 1976-09-24 Bis-(meta-amidinophenoxy)-compounds Expired GB1559983A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51002458A JPS5922697B2 (ja) 1976-01-13 1976-01-13 ビス−（メタ−アミジノフエノキシ）−化合物

Publications (1)

Publication Number Publication Date
GB1559983A true GB1559983A (en) 1980-01-30

Family

ID=11529845

Family Applications (1)

Application Number Title Priority Date Filing Date
GB39861/76A Expired GB1559983A (en) 1976-01-13 1976-09-24 Bis-(meta-amidinophenoxy)-compounds

Country Status (5)

Country Link
US (2) US4034010A (US20110009641A1-20110113-C00116.png)
JP (1) JPS5922697B2 (US20110009641A1-20110113-C00116.png)
DE (1) DE2643090A1 (US20110009641A1-20110113-C00116.png)
FR (1) FR2338039A1 (US20110009641A1-20110113-C00116.png)
GB (1) GB1559983A (US20110009641A1-20110113-C00116.png)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2397387A1 (fr) * 1976-04-27 1979-02-09 Serobiologiques Lab Sa 4,4'-bis-formyl-polyhalo-diphenoxyalcanes, procede de preparation et application a la synthese de 4,4'-dicyano-polyhalo-diphenoxyalcanes
US4262021A (en) * 1977-08-18 1981-04-14 Pfizer Inc. Antiviral amine and amidine derivatives of glycerol and propanediols
US5084480A (en) * 1987-11-06 1992-01-28 Fujisawa Usa, Inc. Pentamidine salts useful in the treatment of pneumocystis carinii pneumonia
WO1991007828A1 (en) * 1989-11-09 1991-05-30 Roger Reed Digital circuit for a frequency modulation and carrier synthesis in a digital radio system
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
KR960004887B1 (ko) * 1991-06-19 1996-04-16 쉐링 코포레이션 경구 활성 항바이러스성 화합물
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives
WO1996028427A1 (en) * 1995-03-10 1996-09-19 Berlex Laboratories, Inc. Benzamidine derivatives their preparation and their use as anti-coagulants
US5691364A (en) * 1995-03-10 1997-11-25 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
US5994375A (en) * 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
US5753635A (en) * 1996-08-16 1998-05-19 Berlex Laboratories, Inc. Purine derivatives and their use as anti-coagulants
US6008234A (en) * 1996-09-12 1999-12-28 Berlex Laboratories, Inc. Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
CN1234798A (zh) 1996-09-12 1999-11-10 舍林股份公司 环状氨基酸和环状羟基羧酸衍生物取代的苄脒衍生物和它们用作抗凝剂的用途
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
CA2315070A1 (en) 1997-12-17 1999-07-01 Schering Aktiengesellschaft Ortho-anthranilamide derivatives as anti-coagulants
DE19819548A1 (de) 1998-04-30 1999-11-04 Merck Patent Gmbh Biphenylderivate
EP1685836A3 (en) * 1998-09-17 2007-05-09 University Of North Carolina At Chapel Hill Antifungal activity of dicationic molecules
DE69933890T2 (de) 1998-09-17 2007-03-15 University Of North Carolina At Chapel Hill Antimykotische wirkung von dikationischen molekülen
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) * 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
JP4664634B2 (ja) * 2003-09-05 2011-04-06 富山化学工業株式会社 新規なベンズアミジン誘導体またはその塩
CN112566631A (zh) * 2018-06-14 2021-03-26 乔治亚州大学研究基金会 用于治疗细菌感染和增强抗生素的脒和脒类似物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2277862A (en) * 1938-12-05 1942-03-31 May & Baker Ltd Process for the preparation of diamidine derivatives
US2449724A (en) * 1945-07-11 1948-09-21 Short Wallace Frank Manufacture of amidines
US3105853A (en) * 1959-11-30 1963-10-01 Monsanto Canada Ltd Bis

Also Published As

Publication number Publication date
DE2643090A1 (de) 1977-07-21
JPS5287135A (en) 1977-07-20
JPS5922697B2 (ja) 1984-05-28
US4064169A (en) 1977-12-20
FR2338039B1 (US20110009641A1-20110113-C00116.png) 1980-03-07
FR2338039A1 (fr) 1977-08-12
US4034010A (en) 1977-07-05

Similar Documents

Publication Publication Date Title
GB1559983A (en) Bis-(meta-amidinophenoxy)-compounds
Daidone et al. Antimicrobial and antineoplastic activities of new 4-diazopyrazole derivatives
Wujec et al. Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-delta2-1, 2, 4-triazoline-5-thiones
US4483866A (en) Agricultural composition and method utilizing 1-benzylimidazole derivatives
WO2000066120A1 (en) Novel catechols as antimicrobial agents
GB2178037A (en) Distamycin derivatives and process for their preparation
EP0221781B1 (en) Benzylamine derivatives, process for production thereof, and use thereof
US4684644A (en) Basic monocarboxyamide derivatives of actagardine having antibiotic activity and compositions thereof
US3417087A (en) 3(aminopropionyl)benzothiophenes
US4515954A (en) Metal chelates of anthracene-9,10-bis-carbonylhydrazones
PL149009B1 (en) Method for manufacturing new derivatives of (benzofuran-2-ilo)imidazoles
US3939177A (en) 4-Aminomethyl-9-benzyl-1,2,3,4-tetrahydrocarbazoles
US4282230A (en) Imidazolylethoxy derivatives of quinoline-2- or 4-methanols, antimicrobial compositions containing them and method for treating bacterial or fungal infections with them
US4044130A (en) Compositions for the control of microorganisms
US4159380A (en) Imidazolylethoxy derivatives of pyrazolo[3,4-b]pyridine-5-methanols
US4169205A (en) Imidazole derivatives of 6,11-dihydrodibenz[b,e]oxepines and 6,11-dihydrodibenz[b,e]thiepines
CN113880780A (zh) 苯甲脒类衍生物、制备方法及应用
US3146232A (en) 5-(5-nitro-2-furyl-mono- and di-vinylene)-1, 3, 4-oxadiazoline-2-one and process
US4582851A (en) Anti-bacterial 1,4-aminoalkylamino-9H-thioxanthen-9-one derivatives, compositions, and method of use therefor
Shinde et al. Design and synthesis of triazine amine derivatives as antibacterial and antifungal agents
US3963774A (en) Anilino derivatives of chelocardin
Rollas et al. N‐[4‐(3H‐1, 3, 4‐Oxadiazoline‐2‐thion‐5‐yl) phenyl]‐N′‐substituted Thioureas: Synthesis and Antimicrobiological Activities
GB2068963A (en) Basic ethers of 4-hydroxy-benzophenones acting as beta-blocking agents and relevant preparation processes
US3622621A (en) 2-alkyl-n-aryl-3-arylimino-1-cyclopenten-1-ylamine salts
US4001265A (en) 3,4-dimethyl-5-isoxazolylsulfamylaniline

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee