GB1554050A - Prostacyclin derivatives - Google Patents

Prostacyclin derivatives

Info

Publication number
GB1554050A
GB1554050A GB36450/77A GB3645077A GB1554050A GB 1554050 A GB1554050 A GB 1554050A GB 36450/77 A GB36450/77 A GB 36450/77A GB 3645077 A GB3645077 A GB 3645077A GB 1554050 A GB1554050 A GB 1554050A
Authority
GB
United Kingdom
Prior art keywords
formula
image
compounds
compound
mercury
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36450/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1554050A publication Critical patent/GB1554050A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)

Abstract

5,9-Cyclic ethers of 9-deoxyprostaglandin-F1 alpha -type compounds of the formula <IMAGE> in which the substituents are defined in Patent Claim 1, are prepared. These compounds are obtained by converting a compound of the formula <IMAGE> into a mercury compound of the formula <IMAGE> and subsequently subjecting this latter compound to a reductive removal of mercury, resulting in the formation of the ether. The compounds which are obtained may be used as antiinflammatory agents as well as for inhibiting blood platelet aggregation in vivo or in vitro.
GB36450/77A 1977-04-19 1977-09-01 Prostacyclin derivatives Expired GB1554050A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78814377A 1977-04-19 1977-04-19
US78814477A 1977-04-19 1977-04-19

Publications (1)

Publication Number Publication Date
GB1554050A true GB1554050A (en) 1979-10-17

Family

ID=27120750

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36450/77A Expired GB1554050A (en) 1977-04-19 1977-09-01 Prostacyclin derivatives

Country Status (9)

Country Link
JP (1) JPS53132573A (en)
AU (1) AU509357B2 (en)
CA (1) CA1184906A (en)
CH (1) CH636347A5 (en)
DE (1) DE2746932A1 (en)
FR (1) FR2387975A1 (en)
GB (1) GB1554050A (en)
NL (1) NL7800011A (en)
SE (1) SE434266B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206127A (en) * 1977-11-23 1980-06-03 Miles Laboratories, Inc. 5,6-Dihydro analogues of prostaglandin I2
JPH02294718A (en) * 1989-05-09 1990-12-05 Fujitsu Ltd Digital signal input circuit
PT1220849E (en) * 1999-10-15 2004-10-29 Sucampo Ag COMPOSITION OF BICYCLIC COMPOUNDS AND METHOD FOR THEIR STABILIZATION
RU2540330C2 (en) 2009-07-28 2015-02-10 Оно Фармасьютикал Ко., Лтд. Bicyclic compound and using it for medical applications
US9029574B2 (en) 2011-01-27 2015-05-12 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
ES2581852T3 (en) * 2011-01-27 2016-09-07 Ono Pharmaceutical Co., Ltd. Bicyclic compound and use thereof for medical purposes
US10899729B2 (en) 2016-06-30 2021-01-26 Ono Pharmaceutical Co.. Ltd. Method for producing bicyclic compound

Also Published As

Publication number Publication date
AU509357B2 (en) 1980-05-08
SE434266B (en) 1984-07-16
SE7709477L (en) 1978-10-20
JPS53132573A (en) 1978-11-18
JPS6151597B2 (en) 1986-11-10
FR2387975A1 (en) 1978-11-17
CA1184906A (en) 1985-04-02
AU2820677A (en) 1979-03-01
NL7800011A (en) 1978-10-23
DE2746932C2 (en) 1988-03-31
FR2387975B1 (en) 1980-08-08
CH636347A5 (en) 1983-05-31
DE2746932A1 (en) 1978-11-02

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee