GB1538603A - Hexetidine salts - Google Patents

Hexetidine salts

Info

Publication number
GB1538603A
GB1538603A GB46121/76A GB4612176A GB1538603A GB 1538603 A GB1538603 A GB 1538603A GB 46121/76 A GB46121/76 A GB 46121/76A GB 4612176 A GB4612176 A GB 4612176A GB 1538603 A GB1538603 A GB 1538603A
Authority
GB
United Kingdom
Prior art keywords
salts
hexetidine
proviso
cooh
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46121/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Doll GmbH
Original Assignee
Doll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2549733A external-priority patent/DE2549733C2/en
Priority claimed from DE19762624980 external-priority patent/DE2624980C2/en
Priority claimed from DE19762626935 external-priority patent/DE2626935A1/en
Application filed by Doll GmbH filed Critical Doll GmbH
Publication of GB1538603A publication Critical patent/GB1538603A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/14—Monocyclic dicarboxylic acids
    • C07C63/15—Monocyclic dicarboxylic acids all carboxyl groups bound to carbon atoms of the six-membered aromatic ring
    • C07C63/26—1,4 - Benzenedicarboxylic acid
    • C07C63/28—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/04—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

There is described a process for the preparation of novel salts of hexetidine with aromatic carboxylic acids of the formula II <IMAGE> in which n denotes 1 or 2 and if n = 1 the substituent X is -COOH, -OH, -NH2, -SO3H or -SO2NH2 with the proviso that X is present as -COOH or -OH in the 4-position, and if n = 2 X has the prior meaning with the proviso that different X radicals are present. The base is reacted with the said acid in a solvent and the salt is obtained by crystallising out. The salts prepared are distinguished by poor solublity in organic solvents and can therefore easily be separated off from accompanying by-products. Pure hexetidine can also be obtained from the resulting salts by reactions with an aqueous base. Since both the salts and the pure hexetidine have antimicrobial activity, they are used in particular as an antiseptic for the oral mucosal membrane.
GB46121/76A 1975-11-06 1976-11-05 Hexetidine salts Expired GB1538603A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2549733A DE2549733C2 (en) 1975-11-06 1975-11-06 1,3-Bis - (β-ethylhexyl) -5-amino-5-methyl-hexahydropyrimidine terephthalate, process for its preparation and pharmaceutical compositions containing it
DE19762624980 DE2624980C2 (en) 1976-06-03 1976-06-03 Salts of 1,3-bis (β-aethyl-hexyl) -5-amino-5-methyl-hexahydropyrimidine, process for their preparation and medicinal preparations containing them
DE19762626935 DE2626935A1 (en) 1976-06-16 1976-06-16 DISINFECTANTS

Publications (1)

Publication Number Publication Date
GB1538603A true GB1538603A (en) 1979-01-24

Family

ID=27186608

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46121/76A Expired GB1538603A (en) 1975-11-06 1976-11-05 Hexetidine salts

Country Status (12)

Country Link
JP (1) JPS5257312A (en)
AU (1) AU508662B2 (en)
CA (1) CA1043336A (en)
CH (1) CH621343A5 (en)
DK (1) DK142846C (en)
ES (1) ES453074A1 (en)
FR (1) FR2330399A1 (en)
GB (1) GB1538603A (en)
GR (1) GR60354B (en)
MX (1) MX4008E (en)
NL (1) NL7612326A (en)
SE (1) SE7612402L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2082724A1 (en) * 2001-11-15 2009-07-29 Laboratorios Miret, S.A. Use of cationic surfactant as antimicrobial activity enhancer in deodorants and oral care

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2082724A1 (en) * 2001-11-15 2009-07-29 Laboratorios Miret, S.A. Use of cationic surfactant as antimicrobial activity enhancer in deodorants and oral care

Also Published As

Publication number Publication date
DK501576A (en) 1977-05-07
FR2330399A1 (en) 1977-06-03
JPS6150950B2 (en) 1986-11-06
SE7612402L (en) 1977-07-06
AU508662B2 (en) 1980-03-27
DK142846B (en) 1981-02-09
CH621343A5 (en) 1981-01-30
MX4008E (en) 1981-10-30
JPS5257312A (en) 1977-05-11
AU1934076A (en) 1978-05-11
CA1043336A (en) 1978-11-28
FR2330399B1 (en) 1980-11-07
ES453074A1 (en) 1977-12-01
NL7612326A (en) 1977-05-10
GR60354B (en) 1978-05-18
DK142846C (en) 1981-08-24

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee