GB1524237A - Cyclic imides processes for their preparation and medicaments containing theseimides - Google Patents

Cyclic imides processes for their preparation and medicaments containing theseimides

Info

Publication number
GB1524237A
GB1524237A GB49626/75A GB4962675A GB1524237A GB 1524237 A GB1524237 A GB 1524237A GB 49626/75 A GB49626/75 A GB 49626/75A GB 4962675 A GB4962675 A GB 4962675A GB 1524237 A GB1524237 A GB 1524237A
Authority
GB
United Kingdom
Prior art keywords
theseimides
processes
preparation
medicaments containing
cyclic imides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49626/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of GB1524237A publication Critical patent/GB1524237A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The novel compounds correspond to the formula: <IMAGE> in which R represents the methyl, ethyl or n-propyl radical. They are prepared starting from beta -phthalimidoglutaric acid or one of its functional derivatives by reaction with an amine H2N-R or a salt thereof, or from a 4-aminopiperidine-2,6-dione substituted on N<1> by R or one of its salts by reaction with phthalic anhydride, phthaloyl chloride or an activated derivative of phthalimide. The compounds, in particular those in which R represents the n-propyl radical, are able to suppress the growth of tumours and have a very low toxicity.
GB49626/75A 1974-12-20 1975-12-03 Cyclic imides processes for their preparation and medicaments containing theseimides Expired GB1524237A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2460304A DE2460304C2 (en) 1974-12-20 1974-12-20 1-n-Propyl-4-phthalimido-piperidine-2,6-dione, process for its preparation and pharmaceuticals containing it

Publications (1)

Publication Number Publication Date
GB1524237A true GB1524237A (en) 1978-09-06

Family

ID=5933927

Family Applications (1)

Application Number Title Priority Date Filing Date
GB49626/75A Expired GB1524237A (en) 1974-12-20 1975-12-03 Cyclic imides processes for their preparation and medicaments containing theseimides

Country Status (14)

Country Link
JP (1) JPS5191268A (en)
AT (1) AT344696B (en)
BE (1) BE836698A (en)
CA (1) CA1058182A (en)
CH (2) CH616671A5 (en)
DE (1) DE2460304C2 (en)
DK (1) DK139386C (en)
ES (1) ES443648A1 (en)
FR (1) FR2294704A1 (en)
GB (1) GB1524237A (en)
IE (1) IE42363B1 (en)
NL (1) NL7514145A (en)
SE (1) SE419860B (en)
ZA (1) ZA756624B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112022012110A2 (en) 2019-12-19 2022-12-13 Arvinas Operations Inc COMPOUNDS AND METHODS FOR TARGETED ANDROGEN RECEPTOR DEGRADATION

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1545706A1 (en) * 1965-05-08 1969-10-09 Gruenenthal Chemie Dicarboximide derivatives and processes for their preparation
DE1670391A1 (en) * 1965-05-08 1970-11-05 Gruenenthal Chemie Dicarboximide derivatives and processes for their preparation
DE1545672B2 (en) * 1965-05-08 1974-11-07 Chemie Gruenenthal Gmbh, 5190 Stolberg Dicarboximide derivatives and processes for their preparation
DE1545707A1 (en) * 1965-05-08 1969-06-12 Gruenenthal Chemie Process for the preparation of dicarboximide derivatives
AT278739B (en) * 1966-11-08 1970-02-10 Kwizda Fa F Johann Process for the preparation of new anhydrides and imides of substituted dicarboxylic acids

Also Published As

Publication number Publication date
NL7514145A (en) 1976-06-22
ES443648A1 (en) 1977-05-01
CH616671A5 (en) 1980-04-15
CH616672A5 (en) 1980-04-15
AT344696B (en) 1978-08-10
SE7512191L (en) 1976-06-21
DE2460304C2 (en) 1983-08-04
FR2294704A1 (en) 1976-07-16
DK139386B (en) 1979-02-12
IE42363B1 (en) 1980-07-30
CA1058182A (en) 1979-07-10
ATA799575A (en) 1977-12-15
BE836698A (en) 1976-06-16
DK139386C (en) 1979-07-23
FR2294704B1 (en) 1979-09-21
JPS5191268A (en) 1976-08-10
SE419860B (en) 1981-08-31
IE42363L (en) 1976-06-20
ZA756624B (en) 1976-09-29
DK583475A (en) 1976-06-21
DE2460304A1 (en) 1976-07-01

Similar Documents

Publication Publication Date Title
GB1058332A (en) Improvements in or relating to the preparation of maleamic acid derivatives
ES462065A1 (en) Thiazolidine derivatives
GB1425354A (en) Indole derivatives
GB1466390A (en) L-tartrate crystals
SE7604476L (en) PROCEDURE FOR PREPARING 1- (3,3,3-TRIARYLPROPYL) -4-PHENYL-4-PIPERIDINEMETHANOL COMPOUNDS
GB1263408A (en) Ara-cytidine derivatives and the manufacture thereof
SE7901493L (en) NEW AMIDE DERIVATIVES OF 5-PYRIMIDINE CARBONIC ACIDS AND METHODS FOR THEIR PREPARATION AND USE AS MEDICINES
GB1386150A (en) 6-acylaminophenyl-4,5-dihydropyridazones
SE7909017L (en) SET TO PREPARE 1,2,3-THIADIAZOL-5-YL CARBAMIDES
SE7411243L (en)
GB1524237A (en) Cyclic imides processes for their preparation and medicaments containing theseimides
GB1415471A (en) Phenylethylamine derivatives
ES405555A1 (en) 7-Alkoxycarbonyl-4-hydroxymethyl-1-phthalazone compounds
SE7607300L (en) THIAXANTENE ASSOCIATIONS AND PROCEDURES FOR THE PREPARATION OF THEM
CH609319A5 (en) Process for the preparation of perfluorinated carbonyl compounds and use of the compounds obtained by this process
GB1458410A (en) 1-oxadethiapenicillanic acid derivatives
GB989557A (en) Hydroxylamine derivative and processes for making it
GB1069337A (en) Basically substituted bis-naphthalimides and their production
ES407866A1 (en) Preparation of n -diethylaminoethyl - 2 - methoxy- 5 - methyl sulphonylbenzamide
SE412907B (en) PROCEDURE FOR PREPARING NEW N-2&#39;-CARBOXIFENYL-4-CHLORANTRANIC ACIDS
GB1502248A (en) Benzofuran derivatives preparation thereof and pharmaceutical compositions thereof
GB1538603A (en) Hexetidine salts
SE7510784L (en) WAY TO PRODUCE NEW, NITROGENIC, POLYCYCLIC ASSOCIATIONS
IE32443B1 (en) Pharmaceutical compositions containing 2-aryl thiazoles
GB1417411A (en) Method of producing cyclic imidic acid esters

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee