GB1538479A - Imidazobenzoxazines - Google Patents
ImidazobenzoxazinesInfo
- Publication number
- GB1538479A GB1538479A GB21111/76A GB2111176A GB1538479A GB 1538479 A GB1538479 A GB 1538479A GB 21111/76 A GB21111/76 A GB 21111/76A GB 2111176 A GB2111176 A GB 2111176A GB 1538479 A GB1538479 A GB 1538479A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- hydrolysed
- converted
- carboxylic acid
- reduced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Abstract
Compounds of formula: <IMAGE> in which R3 represents a C1-C5 alkyl are prepared by decarboxylation of a corresponding alkyl ester carrying a carboxyl in position 1, followed by a nitration. The compound IB can be reduced to an amino ester (IC), can be hydrolysed to the carboxylic acid (IE) or can be reduced and then hydrolysed. The amine compound IC can be converted by acylation into the acylamino compound, and the carboxylic acid IE can be esterified or converted to the amide. The compounds mentioned above and their salts have antiallergic and bronchodilatory properties; they can be used, especially, in the treatment of allergic asthma.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB21111/76A GB1538479A (en) | 1976-05-21 | 1976-05-21 | Imidazobenzoxazines |
FR7715294A FR2351980A1 (en) | 1976-05-21 | 1977-05-18 | NEW IMIDAZOBENZOXAZINES AND THEIR SALTS, METHOD OF PREPARATION AND APPLICATION AS MEDICINAL PRODUCTS |
DK216977A DK216977A (en) | 1976-05-21 | 1977-05-18 | PROCEDURE FOR THE PREPARATION OF IMIDAZOBENZOXAZINES |
DE19772722772 DE2722772A1 (en) | 1976-05-21 | 1977-05-20 | NEW IMIDAZOBENZOXAZINE DERIVATIVES, THEIR SALT, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
CA278,863A CA1100963A (en) | 1976-05-21 | 1977-05-20 | No translation available |
JP52057812A JPS6045199B2 (en) | 1976-05-21 | 1977-05-20 | Novel imidazobenzoxazines and pharmaceutical compositions containing them |
CH623277A CH624118A5 (en) | 1976-05-21 | 1977-05-20 | Processes for the preparation of new imidazobenzoxazines |
BE177750A BE854850A (en) | 1976-05-21 | 1977-05-20 | NEW IMIDAZOBENZOXAZINES AND THEIR SALTS, METHOD OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS |
NL7705614A NL7705614A (en) | 1976-05-21 | 1977-05-20 | PROCESS FOR THE PREPARATION OF NEW IMIDAZO BENZOXAZINS. |
IE1052/77A IE44905B1 (en) | 1976-05-21 | 1977-05-23 | Imidazobenzoxazines |
US05/820,836 US4145419A (en) | 1976-05-21 | 1977-08-01 | Novel imidazobenzoxazines |
CH666280A CH623053A5 (en) | 1976-05-21 | 1980-09-04 | Processes for the preparation of new imidazobenzoxazines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB21111/76A GB1538479A (en) | 1976-05-21 | 1976-05-21 | Imidazobenzoxazines |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1538479A true GB1538479A (en) | 1979-01-17 |
Family
ID=10157418
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB21111/76A Expired GB1538479A (en) | 1976-05-21 | 1976-05-21 | Imidazobenzoxazines |
Country Status (10)
Country | Link |
---|---|
JP (1) | JPS6045199B2 (en) |
BE (1) | BE854850A (en) |
CA (1) | CA1100963A (en) |
CH (2) | CH624118A5 (en) |
DE (1) | DE2722772A1 (en) |
DK (1) | DK216977A (en) |
FR (1) | FR2351980A1 (en) |
GB (1) | GB1538479A (en) |
IE (1) | IE44905B1 (en) |
NL (1) | NL7705614A (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049422A (en) * | 1976-03-29 | 1977-09-20 | United States Borax & Chemical Corporation | Herbicidal morpholinobenzimidazoles |
SE444319B (en) * | 1977-11-18 | 1986-04-07 | Roussel Uclaf | NEW IMIDAZOBENOXAZINE DERIVATIVES, PROCEDURES FOR PREPARING THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE ASSOCIATIONS |
SE439308B (en) * | 1978-08-02 | 1985-06-10 | Roussel Uclaf | IMIDAZO (1,2-A) KINOXALINES AND PHARMACEUTICAL COMPOSITIONS THEREOF |
IL59104A (en) * | 1979-02-09 | 1984-02-29 | Roussel Uclaf | Heterotricyclic derivatives,process for their preparation and pharmaceutical compositions incorporating them |
US5329012A (en) * | 1987-10-29 | 1994-07-12 | The Research Foundation Of State University Of New York | Bis(acyloxmethyl)imidazole compounds |
GB9212486D0 (en) * | 1992-06-12 | 1992-07-22 | Erba Carlo Spa | Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation |
JP6705262B2 (en) * | 2016-04-04 | 2020-06-03 | 三菱ケミカル株式会社 | Curing agent for anion-curable compound, curable composition, and cured product |
-
1976
- 1976-05-21 GB GB21111/76A patent/GB1538479A/en not_active Expired
-
1977
- 1977-05-18 FR FR7715294A patent/FR2351980A1/en active Granted
- 1977-05-18 DK DK216977A patent/DK216977A/en not_active Application Discontinuation
- 1977-05-20 JP JP52057812A patent/JPS6045199B2/en not_active Expired
- 1977-05-20 CA CA278,863A patent/CA1100963A/en not_active Expired
- 1977-05-20 BE BE177750A patent/BE854850A/en unknown
- 1977-05-20 DE DE19772722772 patent/DE2722772A1/en not_active Withdrawn
- 1977-05-20 CH CH623277A patent/CH624118A5/en not_active IP Right Cessation
- 1977-05-20 NL NL7705614A patent/NL7705614A/en not_active Application Discontinuation
- 1977-05-23 IE IE1052/77A patent/IE44905B1/en unknown
-
1980
- 1980-09-04 CH CH666280A patent/CH623053A5/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CH623053A5 (en) | 1981-05-15 |
NL7705614A (en) | 1977-11-23 |
CA1100963A (en) | 1981-05-12 |
FR2351980A1 (en) | 1977-12-16 |
FR2351980B1 (en) | 1980-03-07 |
DE2722772A1 (en) | 1977-12-08 |
CH624118A5 (en) | 1981-07-15 |
JPS6045199B2 (en) | 1985-10-08 |
JPS52156899A (en) | 1977-12-27 |
DK216977A (en) | 1977-11-22 |
IE44905L (en) | 1982-05-05 |
BE854850A (en) | 1977-11-21 |
IE44905B1 (en) | 1982-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |