GB2013689A - Enkephalin analogues - Google Patents

Enkephalin analogues

Info

Publication number
GB2013689A
GB2013689A GB7846692A GB7846692A GB2013689A GB 2013689 A GB2013689 A GB 2013689A GB 7846692 A GB7846692 A GB 7846692A GB 7846692 A GB7846692 A GB 7846692A GB 2013689 A GB2013689 A GB 2013689A
Authority
GB
United Kingdom
Prior art keywords
carboxylic acid
specifically defined
acid amide
enkephalin analogues
tetrapeptide amides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7846692A
Other versions
GB2013689B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of GB2013689A publication Critical patent/GB2013689A/en
Application granted granted Critical
Publication of GB2013689B publication Critical patent/GB2013689B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
    • C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Tetrapeptide amides of the formula <IMAGE> wherein R<1>, B and D represent certain specified substituent groups, and wherein either R<8> is as specifically defined and R<x> is (CH2)s-X wherein s is 2 to 4 and X is specifically defined optionally substituted amine, carboxylic acid, carboxylic acid ester, carboxylic acid amide or oxycarboxylic acid amide group; or NR<8>R<x> represents a heterocyclic ring of specified structure, which tetrapeptide amides have utility as analgesic agents.
GB7846692A 1977-12-15 1978-11-30 Compounds Expired GB2013689B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5223777 1977-12-15

Publications (2)

Publication Number Publication Date
GB2013689A true GB2013689A (en) 1979-08-15
GB2013689B GB2013689B (en) 1982-03-24

Family

ID=10463148

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7846692A Expired GB2013689B (en) 1977-12-15 1978-11-30 Compounds

Country Status (2)

Country Link
BE (1) BE872823A (en)
GB (1) GB2013689B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122018A2 (en) * 1983-03-07 1984-10-17 Eli Lilly And Company Improvements in and relating to pharmacologically active tripeptide derivatives
WO1999032510A1 (en) * 1997-12-23 1999-07-01 Ferring B.V. Kappa receptor opioid peptides

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0122018A2 (en) * 1983-03-07 1984-10-17 Eli Lilly And Company Improvements in and relating to pharmacologically active tripeptide derivatives
EP0122018A3 (en) * 1983-03-07 1985-11-06 Eli Lilly And Company Improvements in and relating to pharmacologically active tripeptide derivatives
WO1999032510A1 (en) * 1997-12-23 1999-07-01 Ferring B.V. Kappa receptor opioid peptides
CZ297281B6 (en) * 1997-12-23 2006-10-11 Cara Therapeutics, Inc. Opioid peptide synthetic amide and pharmaceutical composition in which the amide is comprised

Also Published As

Publication number Publication date
BE872823A (en) 1979-06-15
GB2013689B (en) 1982-03-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee