GB1529974A - Nucleotide derivatives and process for preparing the same - Google Patents
Nucleotide derivatives and process for preparing the sameInfo
- Publication number
- GB1529974A GB1529974A GB42200/75A GB4220075A GB1529974A GB 1529974 A GB1529974 A GB 1529974A GB 42200/75 A GB42200/75 A GB 42200/75A GB 4220075 A GB4220075 A GB 4220075A GB 1529974 A GB1529974 A GB 1529974A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- salified
- stearoyl
- analogues
- oct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003729 nucleotide group Chemical group 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000008209 arabinosides Chemical class 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 230000000052 comparative effect Effects 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 150000008223 ribosides Chemical class 0.000 abstract 2
- -1 1-adamantanecarbonyl Chemical group 0.000 abstract 1
- 229920006310 Asahi-Kasei Polymers 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 150000007933 aliphatic carboxylic acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000007717 exclusion Effects 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 125000003843 furanosyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 125000002264 triphosphate group Chemical group [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11766474A JPS5148682A (ja) | 1974-10-15 | 1974-10-15 | Nukureochidojudotainoseiho |
JP13557474A JPS5163180A (ja) | 1974-11-27 | 1974-11-27 | Nukureochidojudotaino seizoho |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1529974A true GB1529974A (en) | 1978-10-25 |
Family
ID=26455746
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB42200/75A Expired GB1529974A (en) | 1974-10-15 | 1975-10-15 | Nucleotide derivatives and process for preparing the same |
Country Status (5)
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4210638A (en) * | 1978-03-17 | 1980-07-01 | Pcr, Inc. | Antiviral composition and method of treating virus diseases |
CH640412A5 (de) * | 1978-05-26 | 1984-01-13 | Kureha Chemical Ind Co Ltd | Medikament zur behandlung von hyperglykaemie, hyperlipaemie, hypertension, entzuendungen, schmerz, fieber oder tumoren. |
JPS552602A (en) * | 1978-06-20 | 1980-01-10 | Yamasa Shoyu Co Ltd | 1-beta-d-arabinofranosylcytosine-5'-phosphoric acid oleyl ester |
JPS552601A (en) * | 1978-06-20 | 1980-01-10 | Yamasa Shoyu Co Ltd | Anti-tumor agent for non-injection use |
JPS5526669U (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1978-08-11 | 1980-02-21 | ||
GB2037289B (en) * | 1978-10-31 | 1983-05-05 | Katsunuma N | Nucleoside derivatives and an antileukemial agent containing the same as an active ingredient |
US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
JPS61112093A (ja) * | 1984-11-05 | 1986-05-30 | Wakunaga Seiyaku Kk | ヌクレオチド誘導体 |
EP0209996A3 (en) * | 1985-06-25 | 1987-09-02 | Siska Diagnostics,Inc. | Nucleic acid probes comprising n4 -(substituted amino)cytidines |
US5109124A (en) * | 1988-06-01 | 1992-04-28 | Biogen, Inc. | Nucleic acid probe linked to a label having a terminal cysteine |
WO2001036007A2 (en) * | 1999-11-12 | 2001-05-25 | Angiotech Pharmaceuticals, Inc. | Compositions of a combination of radioactive therapy and cell-cycle inhibitors |
US20030216758A1 (en) * | 2001-12-28 | 2003-11-20 | Angiotech Pharmaceuticals, Inc. | Coated surgical patches |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
GB0305422D0 (en) | 2003-03-10 | 2003-04-16 | Univ Open | Detection, monitoring and treatment of cancer |
GB0808357D0 (en) * | 2008-05-08 | 2008-06-18 | Cyclacel Ltd | Process |
WO2011067588A1 (en) * | 2009-12-04 | 2011-06-09 | Generics [Uk] Limited | Cyclic sulphinyl esters of cytidine |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3457253A (en) * | 1965-06-01 | 1969-07-22 | Upjohn Co | 5',5'-di-(ara)-nucleoside phosphates |
US3317512A (en) * | 1965-06-01 | 1967-05-02 | Upjohn Co | 5', 5'-dinucleoside phosphates |
US3423399A (en) * | 1966-06-09 | 1969-01-21 | Takeda Chemical Industries Ltd | Method for the production of 5'-ribonucleotide |
US3773755A (en) * | 1970-12-09 | 1973-11-20 | Us Health Education & Welfare | Conversion of cytidylic acid into aracytidine-3'-phosphate |
US3894000A (en) * | 1971-01-27 | 1975-07-08 | Upjohn Co | Ara-cytidine derivatives and process of preparation |
US3804827A (en) * | 1972-02-28 | 1974-04-16 | Icn Pharmaceuticals | 1-beta-d-arabinofuranosylcytosine-3',5'-cyclic phosphate and derivatives thereof |
-
1975
- 1975-10-15 DE DE19752546073 patent/DE2546073A1/de not_active Withdrawn
- 1975-10-15 FR FR7531569A patent/FR2287910A1/fr active Granted
- 1975-10-15 CH CH1336475A patent/CH614720A5/xx not_active IP Right Cessation
- 1975-10-15 US US05/622,794 patent/US4086417A/en not_active Expired - Lifetime
- 1975-10-15 GB GB42200/75A patent/GB1529974A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
CH614720A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-12-14 |
FR2287910A1 (fr) | 1976-05-14 |
US4086417A (en) | 1978-04-25 |
DE2546073A1 (de) | 1976-04-22 |
FR2287910B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1979-09-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |