GB1528074A - 11-deoxyprostaglandins - Google Patents
11-deoxyprostaglandinsInfo
- Publication number
- GB1528074A GB1528074A GB34528/76A GB3452876A GB1528074A GB 1528074 A GB1528074 A GB 1528074A GB 34528/76 A GB34528/76 A GB 34528/76A GB 3452876 A GB3452876 A GB 3452876A GB 1528074 A GB1528074 A GB 1528074A
- Authority
- GB
- United Kingdom
- Prior art keywords
- optionally substituted
- deoxyprostaglandins
- compounds
- proviso
- cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical compound O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 1
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- -1 alkyl radicals Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
- C07C53/21—Acids containing three or more carbon atoms containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5407—Acyclic saturated phosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60941075A | 1975-09-02 | 1975-09-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1528074A true GB1528074A (en) | 1978-10-11 |
Family
ID=24440691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB34528/76A Expired GB1528074A (en) | 1975-09-02 | 1976-08-19 | 11-deoxyprostaglandins |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US4126754A (cg-RX-API-DMAC7.html) |
| JP (1) | JPS5233651A (cg-RX-API-DMAC7.html) |
| AU (1) | AU502427B2 (cg-RX-API-DMAC7.html) |
| BE (1) | BE845780A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2638827A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2322593A1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB1528074A (cg-RX-API-DMAC7.html) |
| NL (1) | NL7609538A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA764727B (cg-RX-API-DMAC7.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4293704A (en) * | 1975-09-25 | 1981-10-06 | American Cyanamid Company | Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones |
| US4187381A (en) * | 1973-08-06 | 1980-02-05 | Hoffmann-La Roche Inc. | 16-Substituted prostaglandins |
| ZA777142B (en) * | 1976-12-08 | 1978-09-27 | Hoffmann La Roche | Novel prostaglandins |
| DE2702366A1 (de) * | 1977-01-21 | 1978-08-03 | Hoechst Ag | Neue prostaglandin-analoge und verfahren zu ihrer herstellung |
| US4163016A (en) * | 1977-07-05 | 1979-07-31 | Hoffmann-La Roche Inc. | 16-Substituted prostaglandins |
| DE2742407A1 (de) * | 1977-09-21 | 1979-03-29 | Hoechst Ag | Neue fluorhaltige prostaglandinderivate |
| US4312810A (en) * | 1978-11-22 | 1982-01-26 | The Upjohn Company | 2,5-Inter-o-phenylene-3,4-dinor-5,9α-epoxy-9-deoxy-PGF1 compounds |
| US4306078A (en) * | 1979-12-03 | 1981-12-15 | Hoffmann-La Roche Inc. | 16-Substituted prostaglandins |
| US6808933B1 (en) * | 2000-10-19 | 2004-10-26 | Agilent Technologies, Inc. | Methods of enhancing confidence in assays for analytes |
| AU2006209072B2 (en) * | 2005-01-27 | 2011-02-24 | Sucampo Ag | Method and composition for treating central nervous system disorders |
| DE602006018583D1 (de) * | 2005-03-04 | 2011-01-13 | Sucampo Ag | Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten |
| US20180016230A1 (en) * | 2014-12-10 | 2018-01-18 | Apotex Inc. | Salts of Prostaglandin Analog Intermediates |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3935261A (en) * | 1970-01-23 | 1976-01-27 | May & Baker Limited | Cyclopentane derivatives |
| US3932479A (en) * | 1973-04-27 | 1976-01-13 | American Cyanamid Company | Lithium 3-triphenylmethoxy-1-trans-alkenyl-dialkyl alanates |
-
1976
- 1976-08-05 ZA ZA764727A patent/ZA764727B/xx unknown
- 1976-08-06 AU AU16625/76A patent/AU502427B2/en not_active Expired
- 1976-08-19 GB GB34528/76A patent/GB1528074A/en not_active Expired
- 1976-08-27 NL NL7609538A patent/NL7609538A/xx not_active Application Discontinuation
- 1976-08-28 DE DE19762638827 patent/DE2638827A1/de not_active Withdrawn
- 1976-08-28 JP JP51102223A patent/JPS5233651A/ja active Pending
- 1976-09-01 FR FR7626393A patent/FR2322593A1/fr active Granted
- 1976-09-02 BE BE170294A patent/BE845780A/xx not_active IP Right Cessation
-
1978
- 1978-04-17 US US05/897,225 patent/US4126754A/en not_active Expired - Lifetime
- 1978-04-17 US US05/897,222 patent/US4163110A/en not_active Expired - Lifetime
- 1978-04-17 US US05/897,219 patent/US4138577A/en not_active Expired - Lifetime
- 1978-04-17 US US05/897,217 patent/US4138575A/en not_active Expired - Lifetime
- 1978-04-17 US US05/897,220 patent/US4138573A/en not_active Expired - Lifetime
- 1978-04-17 US US05/897,218 patent/US4138576A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2322593B1 (cg-RX-API-DMAC7.html) | 1983-10-21 |
| BE845780A (fr) | 1977-03-02 |
| ZA764727B (en) | 1977-07-27 |
| US4138577A (en) | 1979-02-06 |
| JPS5233651A (en) | 1977-03-14 |
| US4138575A (en) | 1979-02-06 |
| NL7609538A (nl) | 1977-03-04 |
| US4126754A (en) | 1978-11-21 |
| FR2322593A1 (fr) | 1977-04-01 |
| AU502427B2 (en) | 1979-07-26 |
| US4138573A (en) | 1979-02-06 |
| US4163110A (en) | 1979-07-31 |
| AU1662576A (en) | 1978-02-09 |
| DE2638827A1 (de) | 1977-03-10 |
| US4138576A (en) | 1979-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SPA | Amended specification published | ||
| PCNP | Patent ceased through non-payment of renewal fee |