GB1515685A - Aminoglycoside antibiotics - Google Patents
Aminoglycoside antibioticsInfo
- Publication number
- GB1515685A GB1515685A GB46212/75A GB4621275A GB1515685A GB 1515685 A GB1515685 A GB 1515685A GB 46212/75 A GB46212/75 A GB 46212/75A GB 4621275 A GB4621275 A GB 4621275A GB 1515685 A GB1515685 A GB 1515685A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl group
- methyl
- aminoglycoside antibiotics
- eliminated
- methyl groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Reaction of the following compound with an oxidising agent results in preparation of the corresponding demethylated compounds <IMAGE> in which either both R1 and R2 are methyl groups or one of the two radicals is a methyl group and the other is a hydrogen atom. When both R1 and R2 are methyl groups, the methyl group in the 3''-N position or both methyl groups are eliminated, but when one of R1 and R2 is a methyl group and the other hydrogen, the methyl group is eliminated. The resulting compounds are valuable antibiotics.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12931674A JPS573680B2 (en) | 1974-11-09 | 1974-11-09 | |
| JP12931774A JPS5156430A (en) | 1974-11-09 | 1974-11-09 | SHINKOSEIBUTSUSHITSUJUDOTAINO SEIZOHOHO |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1515685A true GB1515685A (en) | 1978-06-28 |
Family
ID=26464745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB46212/75A Expired GB1515685A (en) | 1974-11-09 | 1975-11-07 | Aminoglycoside antibiotics |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT341670B (en) |
| CA (1) | CA1053664A (en) |
| CH (1) | CH617208A5 (en) |
| DE (1) | DE2550168C3 (en) |
| DK (1) | DK502375A (en) |
| ES (1) | ES442472A1 (en) |
| FR (1) | FR2290450A1 (en) |
| GB (1) | GB1515685A (en) |
| IN (1) | IN143025B (en) |
| NL (1) | NL7513082A (en) |
| NO (1) | NO140826C (en) |
| SE (1) | SE422944B (en) |
-
1975
- 1975-11-04 NO NO753691A patent/NO140826C/en unknown
- 1975-11-05 IN IN2118/CAL/1975A patent/IN143025B/en unknown
- 1975-11-07 NL NL7513082A patent/NL7513082A/en not_active Application Discontinuation
- 1975-11-07 SE SE7512520A patent/SE422944B/en unknown
- 1975-11-07 AT AT849775A patent/AT341670B/en not_active IP Right Cessation
- 1975-11-07 DE DE2550168A patent/DE2550168C3/en not_active Expired
- 1975-11-07 CH CH1445575A patent/CH617208A5/en not_active IP Right Cessation
- 1975-11-07 GB GB46212/75A patent/GB1515685A/en not_active Expired
- 1975-11-07 DK DK502375A patent/DK502375A/en unknown
- 1975-11-07 CA CA239,190A patent/CA1053664A/en not_active Expired
- 1975-11-07 FR FR7534183A patent/FR2290450A1/en active Granted
- 1975-11-08 ES ES442472A patent/ES442472A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NO140826B (en) | 1979-08-13 |
| NO140826C (en) | 1979-11-21 |
| ES442472A1 (en) | 1977-08-01 |
| DE2550168B2 (en) | 1978-03-09 |
| AT341670B (en) | 1978-02-27 |
| FR2290450A1 (en) | 1976-06-04 |
| DE2550168C3 (en) | 1978-10-26 |
| CH617208A5 (en) | 1980-05-14 |
| SE422944B (en) | 1982-04-05 |
| NL7513082A (en) | 1976-05-11 |
| DK502375A (en) | 1976-05-10 |
| FR2290450B1 (en) | 1978-05-12 |
| SE7512520L (en) | 1976-05-10 |
| DE2550168A1 (en) | 1976-05-20 |
| ATA849775A (en) | 1977-06-15 |
| CA1053664A (en) | 1979-05-01 |
| AU8646375A (en) | 1977-05-19 |
| IN143025B (en) | 1977-09-24 |
| NO753691L (en) | 1976-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |