ES442472A1 - Aminoglycoside antibiotics - Google Patents

Aminoglycoside antibiotics

Info

Publication number
ES442472A1
ES442472A1 ES442472A ES442472A ES442472A1 ES 442472 A1 ES442472 A1 ES 442472A1 ES 442472 A ES442472 A ES 442472A ES 442472 A ES442472 A ES 442472A ES 442472 A1 ES442472 A1 ES 442472A1
Authority
ES
Spain
Prior art keywords
methyl group
methyl
aminoglycoside antibiotics
eliminated
methyl groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442472A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12931674A external-priority patent/JPS573680B2/ja
Priority claimed from JP12931774A external-priority patent/JPS5156430A/en
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of ES442472A1 publication Critical patent/ES442472A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Reaction of the following compound with an oxidising agent results in preparation of the corresponding demethylated compounds < IMAGE > in which either both R1 and R2 are methyl groups or one of the two radicals is a methyl group and the other is a hydrogen atom. When both R1 and R2 are methyl groups, the methyl group in the 3''-N position or both methyl groups are eliminated, but when one of R1 and R2 is a methyl group and the other hydrogen, the methyl group is eliminated. The resulting compounds are valuable antibiotics.
ES442472A 1974-11-09 1975-11-08 Aminoglycoside antibiotics Expired ES442472A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP12931674A JPS573680B2 (en) 1974-11-09 1974-11-09
JP12931774A JPS5156430A (en) 1974-11-09 1974-11-09 SHINKOSEIBUTSUSHITSUJUDOTAINO SEIZOHOHO

Publications (1)

Publication Number Publication Date
ES442472A1 true ES442472A1 (en) 1977-08-01

Family

ID=26464745

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442472A Expired ES442472A1 (en) 1974-11-09 1975-11-08 Aminoglycoside antibiotics

Country Status (12)

Country Link
AT (1) AT341670B (en)
CA (1) CA1053664A (en)
CH (1) CH617208A5 (en)
DE (1) DE2550168C3 (en)
DK (1) DK502375A (en)
ES (1) ES442472A1 (en)
FR (1) FR2290450A1 (en)
GB (1) GB1515685A (en)
IN (1) IN143025B (en)
NL (1) NL7513082A (en)
NO (1) NO140826C (en)
SE (1) SE422944B (en)

Also Published As

Publication number Publication date
SE422944B (en) 1982-04-05
DE2550168B2 (en) 1978-03-09
DK502375A (en) 1976-05-10
GB1515685A (en) 1978-06-28
AU8646375A (en) 1977-05-19
NO140826C (en) 1979-11-21
FR2290450A1 (en) 1976-06-04
SE7512520L (en) 1976-05-10
AT341670B (en) 1978-02-27
IN143025B (en) 1977-09-24
FR2290450B1 (en) 1978-05-12
ATA849775A (en) 1977-06-15
DE2550168C3 (en) 1978-10-26
NL7513082A (en) 1976-05-11
NO753691L (en) 1976-05-11
CA1053664A (en) 1979-05-01
NO140826B (en) 1979-08-13
CH617208A5 (en) 1980-05-14
DE2550168A1 (en) 1976-05-20

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