GB1513875A - N-cycloalkylmethyl decahydroisoquinolines - Google Patents
N-cycloalkylmethyl decahydroisoquinolinesInfo
- Publication number
- GB1513875A GB1513875A GB23871/75A GB2387175A GB1513875A GB 1513875 A GB1513875 A GB 1513875A GB 23871/75 A GB23871/75 A GB 23871/75A GB 2387175 A GB2387175 A GB 2387175A GB 1513875 A GB1513875 A GB 1513875A
- Authority
- GB
- United Kingdom
- Prior art keywords
- decahydroisoquinoline
- methoxyphenyl
- methyl
- prepared
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1 - Cyclopropylcarbonyl Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 230000000202 analgesic effect Effects 0.000 abstract 2
- NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- JFWMYCVMQSLLOO-UHFFFAOYSA-N cyclobutanecarbonyl chloride Chemical compound ClC(=O)C1CCC1 JFWMYCVMQSLLOO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 abstract 1
- ZOOSILUVXHVRJE-UHFFFAOYSA-N cyclopropanecarbonyl chloride Chemical compound ClC(=O)C1CC1 ZOOSILUVXHVRJE-UHFFFAOYSA-N 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 230000017858 demethylation Effects 0.000 abstract 1
- 238000010520 demethylation reaction Methods 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- AHWALFGBDFAJAI-UHFFFAOYSA-N phenyl carbonochloridate Chemical compound ClC(=O)OC1=CC=CC=C1 AHWALFGBDFAJAI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/477,222 US4001248A (en) | 1974-06-07 | 1974-06-07 | N-cycloalkylmethyl decahydroisoquinolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1513875A true GB1513875A (en) | 1978-06-14 |
Family
ID=23895027
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB23871/75A Expired GB1513875A (en) | 1974-06-07 | 1975-06-03 | N-cycloalkylmethyl decahydroisoquinolines |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4001248A (enExample) |
| AR (1) | AR205202A1 (enExample) |
| AU (1) | AU8166175A (enExample) |
| BE (1) | BE829832A (enExample) |
| CS (1) | CS176142B2 (enExample) |
| DD (1) | DD120437A5 (enExample) |
| DE (1) | DE2524054A1 (enExample) |
| DK (1) | DK250175A (enExample) |
| ES (1) | ES438315A1 (enExample) |
| FR (1) | FR2273541A1 (enExample) |
| GB (1) | GB1513875A (enExample) |
| HU (1) | HU170562B (enExample) |
| IL (1) | IL47389A0 (enExample) |
| NL (1) | NL7506587A (enExample) |
| PL (1) | PL98218B1 (enExample) |
| RO (1) | RO68141A (enExample) |
| SE (1) | SE7506160L (enExample) |
| ZA (1) | ZA753496B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4419517A (en) * | 1973-06-01 | 1983-12-06 | E. I. Du Pont De Nemours & Co. | 4a-Aryl-trans-decahydroisoquinolines |
| US4001248A (en) * | 1974-06-07 | 1977-01-04 | Eli Lilly And Company | N-cycloalkylmethyl decahydroisoquinolines |
| US4042707A (en) * | 1976-02-19 | 1977-08-16 | E. I. Du Pont De Nemours And Company | 3α-Arylhydroisoindoles |
| US4141894A (en) * | 1976-11-02 | 1979-02-27 | Eli Lilly And Company | Trans-5a-aryl-decahydrobenzazepines |
| US4337341A (en) * | 1976-11-02 | 1982-06-29 | Eli Lilly And Company | 4a-Aryl-octahydro-1H-2-pyrindines |
| US4141893A (en) * | 1976-11-02 | 1979-02-27 | Eli Lilly And Company | Decahydrocyclopent[c]azepines |
| US4289882A (en) * | 1978-04-26 | 1981-09-15 | The United States Of America As Represented By The Department Of Health & Human Services | 4A-Aryl-decahydroisoquinolines |
| US4243668A (en) * | 1979-07-09 | 1981-01-06 | E. I. Du Pont De Nemours And Company | Octahydro-1H-benzo[4,5]furo[3,2-e]-isoquinoline analgesic and narcotic antagonistic compounds |
| US4277608A (en) * | 1979-06-21 | 1981-07-07 | Eli Lilly And Company | Method of preparing 4a-arylhexahydro-1H-2-pyrindines and 4a-aryloctahydroisoquinolines |
| US4236009A (en) * | 1979-06-21 | 1980-11-25 | Eli Lilly And Company | Method of preparing 4A-arylhexahydro-1H-2-pyrindines and 4A-aryloctahydroisoquinolines |
| US4579952A (en) * | 1981-12-28 | 1986-04-01 | E. I. Du Pont De Nemours And Company | Intermediates for octahydrobenzofuro[3,2-e]isoquinolines |
| US4537963A (en) * | 1981-12-28 | 1985-08-27 | E. I. Du Pont De Nemours And Company | Intermediates for octahydrobenzofuro[3,2-E]isoquinolines |
| US4421916A (en) * | 1981-12-28 | 1983-12-20 | E. I. Du Pont De Nemours & Co. | Intermediates for octahydrobenzofuro[3,2-e]isoquinolines |
| US4529736A (en) * | 1982-07-28 | 1985-07-16 | American Cyanamid Company | 3a-(Substituted phenyl)-2,3,3a,4,7,7a-hexahydro[or 3a-(substituted-phenyl)octahydro]-4,7-alkano-1H-isoindoles for treating depression in warm-blooded animals |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT330179B (de) * | 1972-07-20 | 1976-06-25 | Du Pont | Verfahren zur herstellung von neuen 4a-aryl- transdecahydroisochinolinderivaten sowie deren optischen isomeren |
| US4001248A (en) * | 1974-06-07 | 1977-01-04 | Eli Lilly And Company | N-cycloalkylmethyl decahydroisoquinolines |
-
1974
- 1974-06-07 US US05/477,222 patent/US4001248A/en not_active Expired - Lifetime
-
1975
- 1975-01-01 AR AR259120A patent/AR205202A1/es active
- 1975-05-29 SE SE7506160A patent/SE7506160L/xx unknown
- 1975-05-29 ZA ZA3496A patent/ZA753496B/xx unknown
- 1975-05-29 AU AU81661/75A patent/AU8166175A/en not_active Expired
- 1975-05-30 IL IL47389A patent/IL47389A0/xx unknown
- 1975-05-30 DE DE19752524054 patent/DE2524054A1/de active Pending
- 1975-06-02 CS CS3848A patent/CS176142B2/cs unknown
- 1975-06-03 FR FR7517313A patent/FR2273541A1/fr not_active Withdrawn
- 1975-06-03 RO RO7582417A patent/RO68141A/ro unknown
- 1975-06-03 NL NL7506587A patent/NL7506587A/xx unknown
- 1975-06-03 DD DD186416A patent/DD120437A5/xx unknown
- 1975-06-03 GB GB23871/75A patent/GB1513875A/en not_active Expired
- 1975-06-03 PL PL1975180885A patent/PL98218B1/pl unknown
- 1975-06-04 DK DK250175A patent/DK250175A/da unknown
- 1975-06-04 BE BE1006702A patent/BE829832A/xx unknown
- 1975-06-06 ES ES438315A patent/ES438315A1/es not_active Expired
- 1975-06-06 HU HUEI628A patent/HU170562B/hu unknown
-
1976
- 1976-10-22 US US05/734,895 patent/US4100166A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2273541A1 (fr) | 1976-01-02 |
| BE829832A (fr) | 1975-12-04 |
| SE7506160L (sv) | 1975-12-08 |
| DK250175A (da) | 1975-12-08 |
| US4100166A (en) | 1978-07-11 |
| NL7506587A (nl) | 1975-12-09 |
| DD120437A5 (enExample) | 1976-06-12 |
| AU8166175A (en) | 1976-12-02 |
| IL47389A0 (en) | 1975-07-28 |
| DE2524054A1 (de) | 1975-12-18 |
| ES438315A1 (es) | 1977-01-16 |
| US4001248A (en) | 1977-01-04 |
| ZA753496B (en) | 1977-01-26 |
| HU170562B (enExample) | 1977-07-28 |
| AR205202A1 (es) | 1976-04-12 |
| CS176142B2 (enExample) | 1977-06-30 |
| PL98218B1 (pl) | 1978-04-29 |
| RO68141A (ro) | 1981-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 49R | Reference inserted (sect. 9/1949) | ||
| SP | Amendment (slips) printed | ||
| PCNP | Patent ceased through non-payment of renewal fee |