GB1510977A - Tetrahydropyridine and piperidine derivatives and processes for the production thereof - Google Patents

Tetrahydropyridine and piperidine derivatives and processes for the production thereof

Info

Publication number
GB1510977A
GB1510977A GB35529/75A GB3552975A GB1510977A GB 1510977 A GB1510977 A GB 1510977A GB 35529/75 A GB35529/75 A GB 35529/75A GB 3552975 A GB3552975 A GB 3552975A GB 1510977 A GB1510977 A GB 1510977A
Authority
GB
United Kingdom
Prior art keywords
carbon atoms
denote
denotes
radical
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB35529/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of GB1510977A publication Critical patent/GB1510977A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals

Abstract

The novel piperidine derivatives of the general formula I <IMAGE> in which R1 denotes a saturated aliphatic hydrocarbon radical having 1-12 or a saturated cycloaliphatic hydrocarbon radical having 3-12 carbon atoms, which radicals can be substituted by hydroxyl groups and/or interrupted by oxygen, or a phenyl-(lower alkyl) or cinnamyl radical which is optionally substituted in a specific manner, R2 denotes hydrogen or a lower alkyl group, R3 and R4 independently of one another denote hydrogen, lower alkyl or lower alkoxy groups, halogen atoms up to atomic number 35, benzyloxy or hydroxyl groups, and R3 also denotes a trifluoromethyl group, a lower 1-hydroxyalkyl group, a 1-hydroxycycloalkyl or cycloalkyl group each having 5-8 carbon atoms, or R3 and R4 together denote the trimethylene, tetramethylene or 1,3-butadienylene radical, R5 denotes hydrogen or an alkyl group having at most 4 carbon atoms and A and B denote divalent saturated aliphatic hydrocarbon radicals and B can also denote the direct bond, where A and B together always form 3 ring members and together with R5 have a total of at most 9 carbon atoms, and their acid addition salts have antidepressant activity. They are prepared by hydrogenation of the corresponding tetrahydropyridine derivatives.
GB35529/75A 1974-08-30 1975-08-28 Tetrahydropyridine and piperidine derivatives and processes for the production thereof Expired GB1510977A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1183774A CH605925A5 (en) 1974-08-30 1974-08-30
CH1511677A CH609980A5 (en) 1974-08-30 1974-08-30 Process for the preparation of novel piperidine derivatives

Publications (1)

Publication Number Publication Date
GB1510977A true GB1510977A (en) 1978-05-17

Family

ID=25709012

Family Applications (1)

Application Number Title Priority Date Filing Date
GB35529/75A Expired GB1510977A (en) 1974-08-30 1975-08-28 Tetrahydropyridine and piperidine derivatives and processes for the production thereof

Country Status (11)

Country Link
JP (1) JPS5148673A (en)
AT (1) AT348523B (en)
AU (1) AU499372B2 (en)
BE (1) BE832885A (en)
CA (1) CA1076118A (en)
CH (2) CH609980A5 (en)
DE (1) DE2537837A1 (en)
FR (1) FR2282887A1 (en)
GB (1) GB1510977A (en)
NL (1) NL7510142A (en)
SE (1) SE7508897L (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668026B2 (en) * 1993-04-28 1996-04-18 Takeda Chemical Industries Ltd. Pyridine derivatives, their production and use
US5891895A (en) * 1996-04-15 1999-04-06 Takeda Chemical Industries, Ltd. Hydroxypyridine derivatives their production and use

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006524A1 (en) * 1978-06-22 1980-01-09 Ciba-Geigy Ag Tetrahydropyridine and tetrahydropiperidine derivatives, their acid addition salts, processes for their preparation and pharmaceutical compositions containing them
US4455427A (en) * 1981-07-01 1984-06-19 The Upjohn Company Pyridyl-substituted-benzofurans
US4495357A (en) * 1981-07-01 1985-01-22 The Upjohn Company Pyridyl-substituted-benzofurans
US4490531A (en) * 1981-07-01 1984-12-25 The Upjohn Company Pyridyl-substituted-benzofurans
US4447620A (en) * 1982-06-08 1984-05-08 The Upjohn Company Imidazolyl-substituted benzothiophenes
US4452986A (en) * 1982-06-08 1984-06-05 The Upjohn Company Imidazolyl-substituted benzofurans
US4611059A (en) * 1982-10-12 1986-09-09 The Upjohn Company Pyridyl-substituted benzothiophenes
US4855435A (en) * 1982-10-12 1989-08-08 The Upjohn Company Pyridyl-substituted benzothiophenes
AU579647B2 (en) * 1985-02-21 1988-12-01 Asahi Kasei Kogyo Kabushiki Kaisha Process for adsorption treatment of dissolved fluorine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668026B2 (en) * 1993-04-28 1996-04-18 Takeda Chemical Industries Ltd. Pyridine derivatives, their production and use
US5716971A (en) * 1993-04-28 1998-02-10 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
US5891895A (en) * 1996-04-15 1999-04-06 Takeda Chemical Industries, Ltd. Hydroxypyridine derivatives their production and use

Also Published As

Publication number Publication date
ATA667875A (en) 1978-07-15
CH609980A5 (en) 1979-03-30
AU8435675A (en) 1977-03-03
FR2282887B1 (en) 1980-04-18
FR2282887A1 (en) 1976-03-26
DE2537837A1 (en) 1976-03-18
CH605925A5 (en) 1978-10-13
NL7510142A (en) 1976-03-02
AT348523B (en) 1979-02-26
AU499372B2 (en) 1979-04-12
CA1076118A (en) 1980-04-22
SE7508897L (en) 1976-03-01
BE832885A (en) 1976-03-01
JPS5148673A (en) 1976-04-26

Similar Documents

Publication Publication Date Title
ATE69813T1 (en) CARBOXAMIDES USEFUL AS ANTIEMETICS OR ANTIPSYCHOTICS.
GB1510977A (en) Tetrahydropyridine and piperidine derivatives and processes for the production thereof
FR2382476A1 (en) LINEAR POLYESTERS, THEIR PREPARATION PROCESS AND THEIR USE
MY105402A (en) 17-beta-substituted-4-aza-5alpha-androstan-3-one derivatives and process for their preparation.
ES449418A1 (en) 1-Phenoxy-{8 imidazolyl-(1){9 -2-hydroxy-alkanes
GB1369248A (en) Amides the preparation thereof and their use in pharmacjeutical compositions
GB1116692A (en) A method for producing sydnonimine derivatives
ES462040A1 (en) Derivatives of perhydro-aza-heterocycles
ES451979A1 (en) Phenylethanolamine derivatives
JPS5543077A (en) Preparation of 1,3-dithiolan-2-ylidenemalonate derivative
DK120483D0 (en) PHENYL PIPERAZINE DERIVATIVES AND PROCEDURES FOR THEIR PREPARATION
MY102921A (en) Amino-alcohol derivatives and processes for their preparation.
ATE78689T1 (en) USE OF -7-THIAPROSTAGLANDIN E1 OR ITS DERIVATIVES FOR THE MANUFACTURE OF AN ANTIDIABETIC.
ES2110454T3 (en) COMPOUNDS OF 6-OXO-AZEPINOINDOL, AS WELL AS PROCEDURE AND INTERMEDIATE PRODUCTS FOR ITS PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS.
ES8106729A1 (en) 4,1-Benzoxazepines
ES8104247A1 (en) 3-(3&#39;-Amino-2&#39;-hydroxy-n-prop-1&#39;-oxy)-6-isopropylidenehydrazino-pyridazines, process for their production and medicaments containing them.
GB872997A (en) Substituted ún-aminoalkoxy-acyl benzenes and processes for their manufacture
FR2275455A1 (en) D-Hydroxyalkyl desoxyvincaminates - by hydrogenation of 2-oxoalkyl desoxyvincaminates and the corresp. apovincaminates (NO190176)
ES457829A1 (en) Bis-penicillanoyloxy-alkanes
FR2220260A1 (en)
SE7905330L (en) NEW CYCLIC ACETALS
FR2163322A1 (en) Tert aminomethyl pentenyl dioxolanes - vasodilators hypotensives spasmolytics diuretics and analgesics
NO902881L (en) PROCEDURE FOR PREPARING AN S-2,2-R1, R2-1,3-DIOKSOLAN-4-METHANOL.
ES446089A1 (en) Procedure for the obtaining of derivatives of tetrahidropiridina and piperidina. (Machine-translation by Google Translate, not legally binding)
ATE25584T1 (en) USE OF GAMMA PIPERIDINO BUTYROPHENONES IN THE MANUFACTURE OF PHARMACEUTICALS FOR THE TREATMENT OF DIARRHOEA.

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee