GB1506833A - 16-substituted steroids of the pregnane series and the preparation of such steroids - Google Patents

16-substituted steroids of the pregnane series and the preparation of such steroids

Info

Publication number
GB1506833A
GB1506833A GB2997176A GB2997176A GB1506833A GB 1506833 A GB1506833 A GB 1506833A GB 2997176 A GB2997176 A GB 2997176A GB 2997176 A GB2997176 A GB 2997176A GB 1506833 A GB1506833 A GB 1506833A
Authority
GB
United Kingdom
Prior art keywords
steroids
alkyl
derivatives
formula
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2997176A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1506833A publication Critical patent/GB1506833A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
GB2997176A 1975-07-23 1976-07-19 16-substituted steroids of the pregnane series and the preparation of such steroids Expired GB1506833A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59844375A 1975-07-23 1975-07-23

Publications (1)

Publication Number Publication Date
GB1506833A true GB1506833A (en) 1978-04-12

Family

ID=24395557

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2997176A Expired GB1506833A (en) 1975-07-23 1976-07-19 16-substituted steroids of the pregnane series and the preparation of such steroids

Country Status (3)

Country Link
FR (1) FR2318647A1 (fr)
GB (1) GB1506833A (fr)
NL (1) NL7607283A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111560047B (zh) * 2020-05-09 2021-07-20 浙江神洲药业有限公司 一种布地奈德的制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704455A (en) * 1984-06-11 1987-11-03 The Upjohn Company 16α-methylatedΔ17(20)-corticoids
JPS611699A (ja) * 1984-06-11 1986-01-07 ジ　アツプジヨン　カンパニー １６α‐メチル化法
US4990612A (en) * 1984-06-11 1991-02-05 The Upjohn Company 16α-methylation process
US4568492A (en) * 1984-09-14 1986-02-04 The Upjohn Company Δ16-20-Keto steroid conversion to 17α-hydroxy-20-keto steroids
HU203768B (en) * 1986-06-04 1991-09-30 Upjohn Co New metilating process for producing 16-alpha-methyl-steroides
FR2681069B1 (fr) * 1991-09-06 1995-04-28 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
FR2700548B1 (fr) * 1993-01-20 1995-03-03 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030389A (en) * 1961-01-23 1962-04-17 Julian Lab Inc Processes for the preparation of 16-alkylpregnenes
US3876633A (en) * 1973-02-21 1975-04-08 Omni Research Processes and intermediates for 16-substituted corticoid synthesis

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111560047B (zh) * 2020-05-09 2021-07-20 浙江神洲药业有限公司 一种布地奈德的制备方法

Also Published As

Publication number Publication date
NL7607283A (nl) 1977-01-25
FR2318647A1 (fr) 1977-02-18
FR2318647B1 (fr) 1978-12-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee