FR2318647A1 - Procede de preparation de pregnanes 16 alpha-substitues - Google Patents

Procede de preparation de pregnanes 16 alpha-substitues

Info

Publication number
FR2318647A1
FR2318647A1 FR7622216A FR7622216A FR2318647A1 FR 2318647 A1 FR2318647 A1 FR 2318647A1 FR 7622216 A FR7622216 A FR 7622216A FR 7622216 A FR7622216 A FR 7622216A FR 2318647 A1 FR2318647 A1 FR 2318647A1
Authority
FR
France
Prior art keywords
pregnanes
substitut
alpha
preparing
substitut pregnanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7622216A
Other languages
English (en)
Other versions
FR2318647B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2318647A1 publication Critical patent/FR2318647A1/fr
Application granted granted Critical
Publication of FR2318647B1 publication Critical patent/FR2318647B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
FR7622216A 1975-07-23 1976-07-21 Procede de preparation de pregnanes 16 alpha-substitues Granted FR2318647A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59844375A 1975-07-23 1975-07-23

Publications (2)

Publication Number Publication Date
FR2318647A1 true FR2318647A1 (fr) 1977-02-18
FR2318647B1 FR2318647B1 (fr) 1978-12-15

Family

ID=24395557

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7622216A Granted FR2318647A1 (fr) 1975-07-23 1976-07-21 Procede de preparation de pregnanes 16 alpha-substitues

Country Status (3)

Country Link
FR (1) FR2318647A1 (fr)
GB (1) GB1506833A (fr)
NL (1) NL7607283A (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0165037A2 (fr) * 1984-06-11 1985-12-18 The Upjohn Company 16 Alpha méthyl stéroides et leur préparation
EP0175540A2 (fr) * 1984-09-14 1986-03-26 The Upjohn Company 20-Sylil éther de stéroides et préparation de 17-hydroxy-20-céto stéroides
WO1987007612A1 (fr) * 1986-06-04 1987-12-17 The Upjohn Company PROCEDE DE 16alpha-METHYLATION
US4929395A (en) * 1984-06-11 1990-05-29 The Upjohn Company 16α-methylation process
US4990612A (en) * 1984-06-11 1991-02-05 The Upjohn Company 16α-methylation process
EP0531212A2 (fr) * 1991-09-06 1993-03-10 Roussel Uclaf Nouveau procédé de préparation de l'hydrocortisone et nouveaux intermédiaires
FR2700548A1 (fr) * 1993-01-20 1994-07-22 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111560047B (zh) * 2020-05-09 2021-07-20 浙江神洲药业有限公司 一种布地奈德的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030389A (en) * 1961-01-23 1962-04-17 Julian Lab Inc Processes for the preparation of 16-alkylpregnenes
DE2407967A1 (de) * 1973-02-21 1974-08-29 Omni Research 16-substituierte corticoide und verfahren zu deren herstellung

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3030389A (en) * 1961-01-23 1962-04-17 Julian Lab Inc Processes for the preparation of 16-alkylpregnenes
DE2407967A1 (de) * 1973-02-21 1974-08-29 Omni Research 16-substituierte corticoide und verfahren zu deren herstellung

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929395A (en) * 1984-06-11 1990-05-29 The Upjohn Company 16α-methylation process
EP0165037A2 (fr) * 1984-06-11 1985-12-18 The Upjohn Company 16 Alpha méthyl stéroides et leur préparation
EP0165037A3 (en) * 1984-06-11 1987-01-21 The Upjohn Company 16 alpha-methyl steroids and their preparation
US4990612A (en) * 1984-06-11 1991-02-05 The Upjohn Company 16α-methylation process
EP0278319A1 (fr) * 1984-06-11 1988-08-17 The Upjohn Company 9,11-Epoxy-21-hydroxy prégnanes
EP0175540A3 (en) * 1984-09-14 1986-09-03 The Upjohn Company 20-silyl ether steroids, and preparing 17-hydroxy-20-keto steroids
EP0175540A2 (fr) * 1984-09-14 1986-03-26 The Upjohn Company 20-Sylil éther de stéroides et préparation de 17-hydroxy-20-céto stéroides
WO1987007612A1 (fr) * 1986-06-04 1987-12-17 The Upjohn Company PROCEDE DE 16alpha-METHYLATION
EP0531212A3 (en) * 1991-09-06 1993-05-26 Roussel-Uclaf New process for the preparation of hydrocortison and new intermediates of this process
FR2681069A1 (fr) * 1991-09-06 1993-03-12 Roussel Uclaf Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.
EP0531212A2 (fr) * 1991-09-06 1993-03-10 Roussel Uclaf Nouveau procédé de préparation de l'hydrocortisone et nouveaux intermédiaires
FR2700548A1 (fr) * 1993-01-20 1994-07-22 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 16 alpha-méthylés.
EP0608178A1 (fr) * 1993-01-20 1994-07-27 Roussel Uclaf Nouveau procédé de préparation de stéroides 16alpha-méthylés
US5508452A (en) * 1993-01-20 1996-04-16 Roussel Uclaf Preparation of 16α-methyl steroids

Also Published As

Publication number Publication date
NL7607283A (nl) 1977-01-25
FR2318647B1 (fr) 1978-12-15
GB1506833A (en) 1978-04-12

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Legal Events

Date Code Title Description
ST Notification of lapse