GB1499414A - Method and apparatus for accurate pipetting of small liquid volumes - Google Patents
Method and apparatus for accurate pipetting of small liquid volumesInfo
- Publication number
- GB1499414A GB1499414A GB2921/75A GB292175A GB1499414A GB 1499414 A GB1499414 A GB 1499414A GB 2921/75 A GB2921/75 A GB 2921/75A GB 292175 A GB292175 A GB 292175A GB 1499414 A GB1499414 A GB 1499414A
- Authority
- GB
- United Kingdom
- Prior art keywords
- small liquid
- liquid volumes
- pipetting
- accurate pipetting
- accurate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/02—Burettes; Pipettes
- B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/041—Connecting closures to device or container
- B01L2300/042—Caps; Plugs
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/04—Closures and closing means
- B01L2300/046—Function or devices integrated in the closure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optical Measuring Cells (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
1499414 Pipetting apparatus O A SUOVANIEMI 23 Jan 1975 [5 July 1974] 2921/75 Heading G1B Apparatus for accurate pipetting includes a thermostatically heated frame 1, with containers 7 therein and a pipette 3 having at least one jet located externally and also thermostatically heated, means being provided to move a jet into a container so as to transfer liquid therefrom to another container. The enclosure may further comprise a shaker.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI353273A FI353273A (en) | 1973-11-14 | 1973-11-14 | |
FI104674A FI57665C (en) | 1974-04-05 | 1974-04-05 | KUVETTENHET |
FI2083/74A FI55093C (en) | 1974-07-05 | 1974-07-05 | FOERFARANDE FOER EXAKT MAETNING AV ABSORPTION AV SMAO VAETSKEMAENGDER SAMT ANORDNING FOER DESS GENOMFOERANDE |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1499414A true GB1499414A (en) | 1978-02-01 |
Family
ID=27240859
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB46540/74A Expired GB1486210A (en) | 1973-11-14 | 1974-10-28 | Cuvette assembly for use in automatic reading and recording of reaction results |
GB2921/75A Expired GB1499414A (en) | 1973-11-14 | 1975-01-23 | Method and apparatus for accurate pipetting of small liquid volumes |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB46540/74A Expired GB1486210A (en) | 1973-11-14 | 1974-10-28 | Cuvette assembly for use in automatic reading and recording of reaction results |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5912982B2 (en) |
CA (1) | CA1031183A (en) |
CH (3) | CH590472A5 (en) |
DE (3) | DE2451769C2 (en) |
DK (1) | DK591774A (en) |
FR (3) | FR2250991B1 (en) |
GB (2) | GB1486210A (en) |
IT (1) | IT1024813B (en) |
NL (3) | NL7414782A (en) |
NO (1) | NO744080L (en) |
SE (1) | SE7413810L (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6433868B1 (en) | 1999-02-15 | 2002-08-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method for differential spectroscopic measurements |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1486210A (en) * | 1973-11-14 | 1977-09-21 | Suovaniemi Osmo Antero | Cuvette assembly for use in automatic reading and recording of reaction results |
US4011048A (en) * | 1976-06-17 | 1977-03-08 | Micromedic Systems, Inc. | Incubation apparatus |
LU77642A1 (en) * | 1976-07-09 | 1977-10-03 | ||
FR2379809A2 (en) * | 1977-02-02 | 1978-09-01 | Dev Automatisme Biolog | Testing liq. microsamples esp. blood with various reagents - with multiple reagent syringes operating simultaneously to load and discharge |
JPS5812550B2 (en) * | 1977-10-05 | 1983-03-09 | 工業技術院長 | Multi-sample multi-item automatic chemical analyzer |
FR2417093A1 (en) * | 1978-02-09 | 1979-09-07 | Dev Automatisme Biolog | Simultaneous transfer of several liq. doses - is effected by syringes with pistons attached to motor driven plate |
DE2839131A1 (en) * | 1978-09-08 | 1980-03-20 | Suovaniemi Finnpipette | Fluid soln. colour intensity or opacity measurement - by passing light beam through samples and determining extinction region |
US4240751A (en) | 1978-11-09 | 1980-12-23 | Akzona Incorporated | Method and apparatus for specific binding substances |
FI790692A (en) * | 1979-03-01 | 1980-09-02 | Suovaniemi Finnpipette | MIKROKYVETTENHET |
JPS55136958A (en) * | 1979-04-14 | 1980-10-25 | Olympus Optical Co Ltd | Automatic analyzer |
EP0030148A1 (en) * | 1979-11-28 | 1981-06-10 | Portalab Instruments Limited | Portable photometer |
ATE3371T1 (en) * | 1980-04-23 | 1983-06-15 | Contraves Ag | SENSOR CANNULES. |
WO1982000354A1 (en) * | 1980-07-24 | 1982-02-04 | Oy Labsystems | Method and apparatus for the measurement of the properties of an agglutination |
WO1982000357A1 (en) * | 1980-07-24 | 1982-02-04 | Oy Labsystems | Method and apparatus for the measurement of the properties of an agglutination |
WO1982000358A1 (en) * | 1980-07-24 | 1982-02-04 | Oy Labsystems | Method of measurement and a cuvette |
WO1982000359A1 (en) * | 1980-07-24 | 1982-02-04 | Oy Labsystems | Set of cuvettes |
EP0056415A1 (en) * | 1980-07-24 | 1982-07-28 | Labsystems Oy | Analyzer |
JPS5733592A (en) * | 1980-08-01 | 1982-02-23 | Fujisawa Pharmaceut Co Ltd | Equipment for identifying bacteria |
FR2488407B1 (en) * | 1980-08-11 | 1984-01-13 | Inst Nat Sante Rech Med | OPTICAL MEASUREMENT METHOD IN VARIABLE OPTICAL PATH AND DEVICE FOR IMPLEMENTING THE METHOD |
JPS5770459A (en) * | 1980-10-22 | 1982-04-30 | Toshiba Corp | Cell cassette |
FI812933L (en) * | 1981-09-21 | 1983-03-22 | Eflab Oy | ANORDINATION FOR MAINTENANCE OF FLUORESCENS |
JPS5891165U (en) * | 1981-12-15 | 1983-06-20 | オリンパス光学工業株式会社 | Particle aggregation determination container |
FI64862C (en) * | 1982-02-05 | 1984-01-10 | Kone Oy | REQUIREMENTS FOR PHOTOMETRIC MAINTENANCE OF THE REQUIREMENTS AND REACTIONS |
JPS5970946A (en) * | 1982-10-15 | 1984-04-21 | Toshiba Corp | Apparatus for measuring absorbance |
FI831936A0 (en) * | 1983-05-30 | 1983-05-30 | Labsystems Oy | FLUORESCENS, TURBIDITY, LUMINESCENS ELLER ABSORPTION |
FI833077A0 (en) * | 1983-08-30 | 1983-08-30 | Labsystems Oy | MED EN VAETSKEDOSERARE FOERSEDD MAETNINGSANORDNING |
DE3336738A1 (en) * | 1983-10-08 | 1985-05-02 | Wolfgang Dr. 7400 Tübingen Heizmann | Titre plate |
FI834756A0 (en) * | 1983-12-22 | 1983-12-22 | Labsystems Oy | KYVETTENHET |
JPS60194168U (en) * | 1984-06-01 | 1985-12-24 | 愛三工業株式会社 | electromagnetic fuel injector |
FR2567538B1 (en) * | 1984-07-12 | 1986-12-26 | Inst Nat Sante Rech Med | AUTOMATON FOR THE ANALYSIS AND CLONING OF CELL CULTURES AND FOR BACTERIOLOGICAL ANALYSIS |
DD239473A1 (en) * | 1985-07-01 | 1986-09-24 | Zeiss Jena Veb Carl | SAMPLE SUPPLIER FOR DISCRETE ANALYSIS OF LIQUID ANALYSIS ASSAYS |
FI852736A0 (en) * | 1985-07-10 | 1985-07-10 | Labsystems Oy | THERMOSTERBAR CAN SEE. |
JPS6188158A (en) * | 1985-09-03 | 1986-05-06 | Olympus Optical Co Ltd | Automatic analysis instrument |
US4675163A (en) * | 1986-03-25 | 1987-06-23 | Mybeck Jessica F | Laboratory device |
US4824642A (en) * | 1986-10-21 | 1989-04-25 | Costar Corporation | Multi-channel pipetter |
US4828386A (en) * | 1987-06-19 | 1989-05-09 | Pall Corporation | Multiwell plates containing membrane inserts |
DE3734588A1 (en) * | 1987-10-13 | 1989-04-27 | Schmidt Werner Dr Rer Nat Habi | Recording photometer of high adaptability |
FR2630928B1 (en) * | 1988-05-03 | 1991-09-06 | Rhone Poulenc Chimie | APPARATUS FOR SUPPORTING AND HEATING REACTION, TREATMENT OR ANALYSIS CONTAINERS OF VARIOUS PRODUCTS |
DE8813340U1 (en) * | 1988-10-24 | 1988-12-08 | Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad | Sample rack for sample vessels |
US5048957A (en) * | 1989-07-11 | 1991-09-17 | Fritz Berthold | Speciman rack with insertable cuvettes |
DE9111441U1 (en) * | 1991-01-26 | 1992-01-09 | Behringwerke Ag, 3550 Marburg | Pipette device with temperature-controlled pipette tube |
DK0496962T3 (en) * | 1991-01-26 | 1995-06-12 | Behringwerke Ag | Pipette tubes with adjustable heating |
US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
EP0542422A1 (en) * | 1991-11-12 | 1993-05-19 | General Atomics | Multi-well microtiter plate |
DE9204388U1 (en) | 1992-03-31 | 1992-06-25 | Jenoptron Gesellschaft für Optoelektronik und Handling mbH, O-6905 Göschwitz | Sealing arrangement |
DE4405375C2 (en) * | 1994-02-19 | 1996-07-25 | Fritz Nerbe Nachfolger Juergen | Microtiter plate |
DE4429383A1 (en) * | 1994-08-12 | 1996-02-15 | Europhoton Gmbh Ges Fuer Optis | Time and space-resolved fluorescence and scattered light measurement |
DE29505897U1 (en) * | 1995-01-12 | 1995-08-24 | Schulz, Joachim, Dipl.-Ing., 06484 Quedlinburg | Thermal shaker |
EP0722136A2 (en) * | 1995-01-12 | 1996-07-17 | Joachim Schulz | Thermostatised shaker |
DE19521947C1 (en) * | 1995-06-16 | 1996-08-22 | Medipro Medizinische Diagnosti | Vibrating water bath assembly with at least two individually temp.-controlled positions |
DE19907011A1 (en) * | 1999-02-18 | 2000-08-31 | Deutsches Krebsforsch | Fluorescence correlation spectroscopy device and method, in particular for multicolor fluorescence correlation spectroscopy |
DE19916748A1 (en) * | 1999-04-14 | 2000-10-19 | Zeiss Carl Jena Gmbh | Fluorescence reaction analysis unit, comprises a transparent container with an adjustable cover that has at least one opening. |
EP1102057A1 (en) * | 1999-11-17 | 2001-05-23 | EG & G Perkin Elmer Ltd. | Sample holder for use in spectroscopic analysis |
FI20000492A0 (en) | 2000-03-03 | 2000-03-03 | Labsystems Oy | Absorbance measurement |
GB0110120D0 (en) * | 2001-04-25 | 2001-06-20 | Medical Res Council | Modified sample plate cover and associated method |
DE10157664A1 (en) * | 2001-11-24 | 2003-06-05 | Stefan Kuerschner | Sample withdrawal device has piston-cylinder unit, in which cylinder is connected to vessel via liquid-guiding fitting with switchable outlet, and piston can be adjusted to receive sample |
GB0303453D0 (en) * | 2003-02-14 | 2003-03-19 | Thermo Clinical Labsystems Oy | Automated sample analyzer and cuvette |
DE10324397A1 (en) * | 2003-05-28 | 2005-01-20 | Hte Ag The High Throughput Experimentation Company | Modular sample holder, to hold and prepare samples for analysis, has a module with sample holders held in a second module in turn held in a third module |
DE102004020591A1 (en) * | 2004-04-27 | 2005-11-17 | Carl Zeiss Jena Gmbh | measuring device |
DE102006044324A1 (en) * | 2006-09-18 | 2008-03-27 | Labor L + S Aktiengesellschaft | Method for the photometric measurement of a liquid sample contained in sample container, comprises irradiating liquid sample during the measurement with a photometric measuring beam and detecting its absorption |
CN101674887B (en) | 2006-11-09 | 2013-01-02 | Asmag控股有限公司 | Titer plate with thin-film-light sensor |
US8877507B2 (en) | 2007-04-06 | 2014-11-04 | Qiagen Gaithersburg, Inc. | Ensuring sample adequacy using turbidity light scattering techniques |
US8703492B2 (en) | 2007-04-06 | 2014-04-22 | Qiagen Gaithersburg, Inc. | Open platform hybrid manual-automated sample processing system |
US8355132B2 (en) | 2007-04-06 | 2013-01-15 | Qiagen Gaithersburg, Inc. | Sample adequacy measurement system having a plurality of sample tubes and using turbidity light scattering techniques |
EP2045015B1 (en) * | 2007-10-01 | 2011-11-23 | Tecan Trading AG | Micro-cuvette assembly and its utilisation |
AT510898B1 (en) * | 2007-12-21 | 2014-11-15 | Medizinische Universität Graz | MENISKUS EQUILIBRATION SYSTEM FOR A MICROTITER PLATE |
EP2255172B2 (en) * | 2008-02-29 | 2019-01-23 | Starna Cells, Inc. | Method of validating a vertical light beam spectrophotometer |
US8115922B2 (en) | 2008-02-29 | 2012-02-14 | Starna Cells, Inc. | Apparatus and method for adapting conventional cuvettes for use in a vertical light beam spectrophotometer |
JP2014077665A (en) * | 2012-10-09 | 2014-05-01 | Aoi Seiki Kk | Container for sample fractionation |
KR101562318B1 (en) * | 2014-02-10 | 2015-10-22 | 나노바이오시스 주식회사 | Microfluidic chip and real-time analyzing apparatus using the same |
KR101696259B1 (en) * | 2014-07-23 | 2017-01-13 | 나노바이오시스 주식회사 | Multiplex pcr chip and multiplex pcr device comprising the same |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3415361A (en) * | 1966-12-22 | 1968-12-10 | Miles Lab | Test device and container therefor |
US3190731A (en) * | 1961-03-08 | 1965-06-22 | Technicon Instr | Sample-supply cups for analysis apparatus |
US3540858A (en) * | 1968-01-22 | 1970-11-17 | Beckman Instruments Inc | Sample holder with filter means |
FR1562948A (en) * | 1968-01-23 | 1969-04-11 | ||
DE1988396U (en) * | 1968-04-18 | 1968-06-27 | Siemens Ag | SAMPLE TUBES FOR TAKING UP BODY FLUIDS. |
FR1592765A (en) * | 1968-11-21 | 1970-05-19 | ||
GB1322728A (en) * | 1969-11-05 | 1973-07-11 | Smith Kline French Lab | Mixing and measuring container for spectrophotometric analyzing apparatus |
US3781120A (en) * | 1970-09-14 | 1973-12-25 | Technicon Instr | Self-locating sample receptacle having integral identification label |
US3680967A (en) * | 1970-09-14 | 1972-08-01 | Technicon Instr | Self-locating sample receptacle having integral identification label |
GB1486210A (en) * | 1973-11-14 | 1977-09-21 | Suovaniemi Osmo Antero | Cuvette assembly for use in automatic reading and recording of reaction results |
-
1974
- 1974-10-28 GB GB46540/74A patent/GB1486210A/en not_active Expired
- 1974-10-31 DE DE2451769A patent/DE2451769C2/en not_active Expired
- 1974-10-31 DE DE2463113A patent/DE2463113C2/en not_active Expired
- 1974-11-04 SE SE7413810A patent/SE7413810L/xx unknown
- 1974-11-11 CH CH1513574A patent/CH590472A5/xx not_active IP Right Cessation
- 1974-11-11 CH CH305677A patent/CH590085A5/xx not_active IP Right Cessation
- 1974-11-12 CA CA213,512A patent/CA1031183A/en not_active Expired
- 1974-11-12 IT IT70323/74A patent/IT1024813B/en active
- 1974-11-13 DK DK591774A patent/DK591774A/da not_active Application Discontinuation
- 1974-11-13 NL NL7414782A patent/NL7414782A/en not_active Application Discontinuation
- 1974-11-13 NO NO744080A patent/NO744080L/no unknown
- 1974-11-14 JP JP49131557A patent/JPS5912982B2/en not_active Expired
- 1974-12-13 FR FR7442147A patent/FR2250991B1/fr not_active Expired
-
1975
- 1975-01-23 GB GB2921/75A patent/GB1499414A/en not_active Expired
- 1975-02-01 DE DE19752504269 patent/DE2504269A1/en active Granted
- 1975-02-03 CH CH141175A patent/CH585400A5/xx not_active IP Right Cessation
- 1975-03-07 FR FR7507953A patent/FR2277341A1/en active Granted
- 1975-03-12 NL NL7502918A patent/NL7502918A/en not_active Application Discontinuation
-
1978
- 1978-01-06 FR FR7800847A patent/FR2363098A1/en active Granted
-
1981
- 1981-11-12 NL NL8105126A patent/NL8105126A/en not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6433868B1 (en) | 1999-02-15 | 2002-08-13 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method for differential spectroscopic measurements |
Also Published As
Publication number | Publication date |
---|---|
FR2363098B1 (en) | 1980-04-18 |
IT1024813B (en) | 1978-07-20 |
FR2277341B3 (en) | 1978-07-21 |
CA1031183A (en) | 1978-05-16 |
FR2250991B1 (en) | 1978-09-29 |
DE2451769A1 (en) | 1975-05-15 |
JPS5912982B2 (en) | 1984-03-27 |
NO744080L (en) | 1975-06-09 |
JPS5089092A (en) | 1975-07-17 |
DE2463113C2 (en) | 1985-06-27 |
FR2277341A1 (en) | 1976-01-30 |
DE2504269A1 (en) | 1976-01-22 |
AU7516274A (en) | 1976-05-13 |
CH590472A5 (en) | 1977-08-15 |
DE2451769C2 (en) | 1985-07-04 |
GB1486210A (en) | 1977-09-21 |
AU7792975A (en) | 1976-08-05 |
DE2504269C2 (en) | 1988-10-20 |
DK591774A (en) | 1975-07-14 |
NL7414782A (en) | 1975-05-16 |
FR2250991A1 (en) | 1975-06-06 |
NL8105126A (en) | 1982-03-01 |
NL7502918A (en) | 1976-01-07 |
CH590085A5 (en) | 1977-07-29 |
FR2363098A1 (en) | 1978-03-24 |
CH585400A5 (en) | 1977-02-28 |
SE7413810L (en) | 1975-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |