GB1498332A - Artificial beta cell and computer programmed therefor - Google Patents

Artificial beta cell and computer programmed therefor

Info

Publication number
GB1498332A
GB1498332A GB1264/76A GB126476A GB1498332A GB 1498332 A GB1498332 A GB 1498332A GB 1264/76 A GB1264/76 A GB 1264/76A GB 126476 A GB126476 A GB 126476A GB 1498332 A GB1498332 A GB 1498332A
Authority
GB
United Kingdom
Prior art keywords
blood
computer
glucose
reservoir
fed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1264/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hospital for Sick Children HSC
Original Assignee
Hospital for Sick Children HSC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hospital for Sick Children HSC filed Critical Hospital for Sick Children HSC
Publication of GB1498332A publication Critical patent/GB1498332A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Optics & Photonics (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • External Artificial Organs (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

1498332 Automatic control HOSPITAL FOR SICK CHILDREN 13 Jan 1976 [22 Jan 1975] 01264/76 Heading G3N A computer for use in an artificial beta cell is responsive to a programme to relate an input signal indicating the concentration of blood glucose in blood taken from a diabetic subject to an output signal which determines a rate of glucose infusion required to control the blood glucose at a desired level. As shown, in an artificial beta cell blood is withdrawn from a subject 20 through a catheter 22 and, together with an anti-coagulant from a reservoir 24, fed by a peristaltic pump 28 to a glucose analyzer 32. A visual read-out of blood glucose concentration (BG) is provided by a chestrecorder 34 having a retransmitting slide-wire. The analog signal BG is converted to a digital signal in a converter 36 and fed to a digital computer 38. The computer is programmed to average the differences in the values of BG over fixed time intervals and by weighting a succession of averages determine a rate of change of blood-glucose concentration B<SP>#</SP>G. By an algorithm, set out in the Specification, the computer provides an output signal determining the required infusion rate of insulin (R1). This signal is fed to an interface 42 which controls a pulsatile pump 44 receiving insulin from a reservoir 46. Saline solution is added from a reservoir 56 by a peristaltic pump 54. A back-up dextrose supply, shown in dashed lines, may be provided.
GB1264/76A 1975-01-22 1976-01-13 Artificial beta cell and computer programmed therefor Expired GB1498332A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA218,410A CA1040271A (en) 1975-01-22 1975-01-22 Artificial beta cell

Publications (1)

Publication Number Publication Date
GB1498332A true GB1498332A (en) 1978-01-18

Family

ID=4102116

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1264/76A Expired GB1498332A (en) 1975-01-22 1976-01-13 Artificial beta cell and computer programmed therefor

Country Status (8)

Country Link
JP (1) JPS51125993A (en)
AU (1) AU1032476A (en)
CA (1) CA1040271A (en)
DE (1) DE2601893A1 (en)
FR (1) FR2298832A1 (en)
GB (1) GB1498332A (en)
IT (1) IT1053386B (en)
SE (1) SE7600588L (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027470A1 (en) * 1979-04-30 1981-04-29 Lichtenstein Eric Stefan Computer-controlled medical care system.
US7037277B1 (en) 1998-07-21 2006-05-02 Spectrx, Inc. System and method for fluid management in a continuous fluid collection and sensor device
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2737922A1 (en) * 1977-08-23 1979-03-08 Fresenius Chem Pharm Ind ARTIFICIAL ENDOCRINE DRUESE
US4151845A (en) * 1977-11-25 1979-05-01 Miles Laboratories, Inc. Blood glucose control apparatus
US4469681A (en) * 1979-07-31 1984-09-04 The Rockefeller University Method and system for the controlled release of biologically active substances to a body fluid
US4348387A (en) * 1979-07-31 1982-09-07 The Rockefeller University Method and system for the controlled release of biologically active substances to a body fluid
JPS58198351A (en) * 1982-05-15 1983-11-18 株式会社京都第一科学 Method and apparatus for continuously measuring specific component in diluted liquid
JPS598969A (en) * 1982-07-09 1984-01-18 藤沢薬品工業株式会社 Artificial pancreas
FR2531333B1 (en) * 1982-08-09 1986-04-04 Centre Nat Rech Scient BIO-ARTIFICIAL PANCREAS WITH ULTRAFILTRATION
DD230730A3 (en) * 1984-01-02 1985-12-11 Zentralinstitut Fuer Diabetes DEVICE FOR THE PROSPECTIVE AUTOMATIC DETERMINATION OF INDIVIDUAL-SPECIFIC GLUCOSE REGULATION PARAMETERS
CA1254091A (en) * 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
DE3545260A1 (en) * 1985-12-20 1987-06-25 Juergen Schrezenmeir DEVICE FOR THE CONTINUOUS OR DISCONTINUOUS ADMINISTRATION OF INSULIN IN HUMAN BODIES
GB8818690D0 (en) * 1988-08-05 1988-09-07 Red Kite Technology Ltd Refractive index measurement
AUPR632301A0 (en) * 2001-07-11 2001-08-02 Chee, Frederick Howe-Hui Infusion apparatus for regulating blood glucose levels
US7509156B2 (en) 2005-05-18 2009-03-24 Clarian Health Partners, Inc. System for managing glucose levels in patients with diabetes or hyperglycemia
WO2009049252A1 (en) * 2007-10-10 2009-04-16 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
US10737024B2 (en) 2015-02-18 2020-08-11 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
WO2017123525A1 (en) 2016-01-13 2017-07-20 Bigfoot Biomedical, Inc. User interface for diabetes management system
WO2017124006A1 (en) 2016-01-14 2017-07-20 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
WO2018058041A1 (en) 2016-09-23 2018-03-29 Insulet Corporation Fluid delivery device with sensor
US11027063B2 (en) 2017-01-13 2021-06-08 Bigfoot Biomedical, Inc. Insulin delivery methods, systems and devices
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
WO2019213493A1 (en) 2018-05-04 2019-11-07 Insulet Corporation Safety constraints for a control algorithm-based drug delivery system
CN112789070A (en) 2018-09-28 2021-05-11 英赛罗公司 Mode of activity of the artificial pancreas System
EP3864668A1 (en) 2018-10-11 2021-08-18 Insulet Corporation Event detection for drug delivery system
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
EP4354455A2 (en) 2019-12-06 2024-04-17 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11986630B2 (en) 2020-02-12 2024-05-21 Insulet Corporation Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
US11738144B2 (en) 2021-09-27 2023-08-29 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027470A1 (en) * 1979-04-30 1981-04-29 Lichtenstein Eric Stefan Computer-controlled medical care system.
EP0027470A4 (en) * 1979-04-30 1981-09-01 Lichtenstein Eric Stefan Computer-controlled medical care system.
US7037277B1 (en) 1998-07-21 2006-05-02 Spectrx, Inc. System and method for fluid management in a continuous fluid collection and sensor device
US7384396B2 (en) 1998-07-21 2008-06-10 Spectrx Inc. System and method for continuous analyte monitoring

Also Published As

Publication number Publication date
FR2298832A1 (en) 1976-08-20
JPS51125993A (en) 1976-11-02
CA1040271A (en) 1978-10-10
DE2601893A1 (en) 1976-07-29
IT1053386B (en) 1981-08-31
AU1032476A (en) 1977-07-21
SE7600588L (en) 1976-07-23

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee