CN213219990U - Diabetes patient management system based on continuous monitoring of sweat and insulin infusion - Google Patents
Diabetes patient management system based on continuous monitoring of sweat and insulin infusion Download PDFInfo
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- CN213219990U CN213219990U CN202021311437.4U CN202021311437U CN213219990U CN 213219990 U CN213219990 U CN 213219990U CN 202021311437 U CN202021311437 U CN 202021311437U CN 213219990 U CN213219990 U CN 213219990U
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Abstract
The utility model discloses a diabetes patient management system based on continuous monitoring of sweat and insulin infusion, which comprises a sweat detection module, a data processing module, a communication module, an insulin infusion calculation module and an insulin pump module, wherein the sweat detection module collects sweat and electrolyzes glucose in the sweat and transmits current generated by electrolyzing glucose to the data processing module; the data processing module determines the concentration of the sweat and determines the concentration of the blood sugar according to the concentration of the sweat; the insulin infusion calculation module determines the infusion amount of insulin according to the continuously detected blood glucose concentration and transmits the infusion amount of the insulin to the insulin pump through the communication module; the insulin pump receives the insulin infusion instruction and the insulin infusion amount and performs insulin injection on the patient. The utility model discloses utilize the glucose in the continuous monitoring diabetes patient sweat of no enzyme sensor, confirm patient's blood glucose value through glucose concentration in the detection sweat, and then confirm the insulin injection volume, realized not having the wound measurement.
Description
Technical Field
The utility model relates to an electrochemical detection of physiological glucose, concretely relates to diabetes mellitus patient management system based on sweat continuous monitoring and insulin infusion.
Background
The international diabetes union (IDF)2019 showed about 4.63 hundred million adult diabetics worldwide, with about 1.11 million diabetics over the age of 65. About 420 thousands of adults died from diabetes and complications thereof in 2019, accounting for 11.3% of the total number of death worldwide, and the health management of diabetes patients becomes a problem to be urgently solved. Insulin injection is currently the primary treatment modality for controlling blood glucose levels in diabetic patients. The traditional way of insulin injection is to administer the drug to the patient by means of a syringe or an insulin pen, and a more convenient way of injection is by means of an insulin pump, all of which determine the injection volume based on the blood glucose level of the patient.
The conventional blood glucose measuring method is to take measurements by collecting blood from fingertips, and a diabetic needs to measure blood glucose several times a day to determine the insulin injection amount. Blood glucose levels of diabetic patients vary greatly during the day, which cannot be reflected by this method, and invasive detection of multiple pricked fingers places a physical and psychological burden on the patient.
SUMMERY OF THE UTILITY MODEL
The purpose of the invention is as follows: an object of the utility model is to provide a realize not having the wound measurement, confirm patient's blood glucose value through glucose concentration in detecting the sweat, and then confirm the diabetes mellitus patient management system based on sweat continuous monitoring and insulin infusion of insulin injection volume.
The technical scheme is as follows: the utility model comprises a sweat detection module, a data processing module, a communication module, an insulin infusion calculation module and an insulin pump module, wherein the sweat detection module is connected with the data processing module, collects sweat and electrolyzes glucose in the sweat, and then transmits the current generated by electrolyzing glucose to the data processing module; the data processing module determines the concentration of glucose in sweat and determines the concentration of glucose in plasma according to the concentration of glucose in sweat; the data processing module is connected with the insulin infusion calculation module and the insulin infusion calculation module is connected with the insulin pump through the communication module, the insulin infusion calculation module determines the infusion amount of insulin according to the continuously detected glucose concentration in the blood plasma, and the infusion amount of the insulin is transmitted to the insulin pump through the communication module; the insulin pump receives the insulin infusion instruction and the insulin infusion amount transmitted by the insulin infusion calculation module and injects the insulin to the patient.
The sweat detection module comprises a power supply module, a sweat collection module and an enzyme-free sensor; the enzyme-free sensor comprises a working electrode, a reference electrode and a counter electrode, in the process of detecting the sweat, glucose in the sweat is electrolyzed by applying different pressures to the working electrode and the reference electrode respectively at different time periods, and the process does not involve glucose oxidase, so that the high repeatability of the sensor is ensured.
The current generated by the electrolytic glucose is transmitted to the data processing module through the circuit board.
The data processing module determines the concentration of glucose in sweat according to the quantity relation between the current generated by glucose electrolysis and the glucose electrolysis, and the measurement result is more scientific and reliable.
The storage module is connected with the data processing module and the insulin infusion calculation module through the communication module and is used for storing continuous blood glucose data and insulin injection data of the patient and forming long-term blood glucose data and insulin injection data of the patient.
Still include the display module, the display module is connected with storage module for show patient's continuous blood glucose data and insulin injection data curve, make things convenient for the doctor to know patient's blood glucose condition, provide data reference for patient's treatment.
The sweat detection module, the data processing module and the communication module are manufactured into a flexible circuit board, so that the wearable device can be finally manufactured into a head-wearing type or wrist-wearing type wearable device.
The communication module adopts Bluetooth communication, and wireless communication is realized.
Has the advantages that: compared with the prior art, the utility model, its beneficial effect lies in: (1) the blood glucose value of the patient is determined by detecting the glucose in the sweat, so that noninvasive detection is realized; (2) can display the continuous blood sugar data and the insulin injection data curve of the patient and provide data reference for the treatment of the patient; (3) the data can be stored to form the personal long-term blood glucose data of the patient.
Drawings
FIG. 1 is a block diagram of the present invention;
fig. 2 is a flow chart of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and the accompanying drawings.
As shown in figure 1, the utility model discloses a sweat detects module, data processing module, communication module, insulin infusion calculation module, insulin pump module, storage module and display module. The sweat detection module comprises a power supply module, a sweat collection module and an enzyme-free sensor. The sweat collection module collects sweat on the wrist or the head, and provides raw materials and places for sweat detection. The enzyme-free sensor comprises a working electrode, a reference electrode and a counter electrode, glucose in sweat is electrolyzed by applying different pressures to the working electrode and the reference electrode respectively in different time periods in the process of detecting the sweat, a sweat detection module is connected with a data processing module, and the current generated by electrolyzing the glucose is transmitted to the data processing module by the sweat detection module through a circuit board. The glucose oxidase is not involved in the process, so that the high repeatability of the sensor is ensured.
As shown in fig. 2, sweat generated by human body movement or other daily activities is collected in a small groove by a sweat collecting device, a three-electrode system is inserted into the groove, and when the glucose content in the sweat is detected, stable voltage is supplied to the sweat by a power supply module of a flexible circuit. The time when the detection is started is set to t 0, 0V is applied to reference electrode R, 1V is applied to working electrode W, and the voltage of working electrode W with respect to reference electrode R is maintained at + 1V. t is 2s, 2V is applied to reference electrode R, 0V is applied to working electrode W, and the state is maintained for 20s with the voltage of working electrode W relative to reference electrode R kept at-2V. When t is 22s, reference electrode R applies 0V, working electrode W applies 0.1V, and the voltage of working electrode W relative to the reference electrode is maintained at + 0.1V. And transmitting the current i generated in the process to a data processing module through the circuit board.
Human glucose produces, utilizes and insulin between there is complicated physiological process, the utility model discloses a to the physiological process establishment mathematical model in glucose transmits the sweat in the plasma in advance, combine the control algorithm of insulin infusion, calculate diabetic's insulin infusion volume. The data processing module receives the current in the sweat glucose detection process and determines the glucose concentration in the sweat according to the quantitative relation between the current generated by glucose electrolysis and the glucose electrolysis. Then, the glucose concentration in sweat is used as the input of the glucose insulin kinetic model, and the corresponding glucose concentration in blood plasma is obtained through output. Wherein, the glucose insulin kinetic model is prior art, does not belong to the utility model discloses the content of claim, and this prior art is: CN98810334.6, insoluble insulin composition. And the continuously detected glucose concentration in the blood plasma is sent to a storage module through a communication module to be stored, so that the personal long-term blood glucose data of the patient is formed. In this embodiment, the communication module adopts bluetooth communication.
The data processing module, the insulin infusion calculating module and the insulin pump are connected through the communication module. The data processing module sends the concentration of the glucose in the blood plasma to an insulin infusion calculation module through the communication module, and the insulin infusion calculation module comprises a glucose insulin kinetic model of the diabetic patient and an insulin infusion control algorithm. Wherein, the insulin infusion control algorithm is prior art, does not belong to the utility model discloses the content of claim, and this prior art is: a daily variability model of blood glucose-insulin regulation after 12 weeks of family administration with closed-loop insulin, IEEE bioengineering, 2017, was established. The insulin infusion calculating module determines the infusion amount of insulin according to the continuously detected glucose concentration in the blood plasma, the insulin infusion amount is transmitted to the insulin pump through the communication module, and the insulin pump receives the insulin infusion instruction and the infusion amount transmitted by the insulin infusion calculating module and performs insulin injection on a patient. The insulin injection data is also sent to the storage module through the communication module to be stored, and long-term insulin injection data of the patient is formed. The display module is connected with the storage module and is used for displaying the continuous blood sugar data and the insulin injection data curve of the patient. In this embodiment, the sweat detection module, the data processing module and the communication module are manufactured into a flexible circuit board, and then manufactured into a head-wearing type or wrist-wearing type wearable device.
Claims (8)
1. Diabetes mellitus patient management system based on sweat continuous monitoring and insulin infusion its characterized in that: the device comprises a sweat detection module, a data processing module, a communication module, an insulin infusion calculation module and an insulin pump module, wherein the sweat detection module is connected with the data processing module, collects sweat and electrolyzes glucose in the sweat, and then transmits current generated by electrolyzing the glucose to the data processing module; the data processing module determines the concentration of glucose in sweat and determines the concentration of glucose in plasma according to the concentration of glucose in sweat; the data processing module is connected with the insulin infusion calculation module and the insulin infusion calculation module is connected with the insulin pump through the communication module, the insulin infusion calculation module determines the infusion amount of insulin according to the continuously detected glucose concentration in the blood plasma, and the infusion amount of the insulin is transmitted to the insulin pump through the communication module; the insulin pump receives the insulin infusion instruction and the insulin infusion amount transmitted by the insulin infusion calculation module and injects the insulin to the patient.
2. The continuous sweat monitoring and insulin infusion based diabetes patient management system of claim 1, wherein: the sweat detection module comprises a power supply module, a sweat collection module and an enzyme-free sensor; wherein the enzyme-free sensor comprises a working electrode, a reference electrode and a counter electrode, and glucose in sweat is electrolyzed by applying different pressures to the working electrode and the reference electrode respectively at different time periods in the process of detecting the sweat.
3. The continuous sweat monitoring and insulin infusion based diabetes patient management system of claim 1, wherein: the current generated by the electrolytic glucose is transmitted to the data processing module through the circuit board.
4. The continuous sweat monitoring and insulin infusion based diabetes patient management system of claim 1, wherein: the data processing module determines the glucose concentration in sweat based on a quantitative relationship between the current generated by electrolyzing glucose and the electrolysis of glucose.
5. The continuous sweat monitoring and insulin infusion based diabetes patient management system of claim 1, wherein: the device also comprises a storage module, wherein the storage module is connected with the data processing module and the insulin infusion calculation module through the communication module and is used for storing continuous blood glucose data and insulin injection data of the patient.
6. The continuous sweat glucose monitoring and insulin infusion based diabetes patient management system of claim 5, wherein: the device also comprises a display module, wherein the display module is connected with the storage module and is used for displaying the continuous blood glucose data and the insulin injection data curve of the patient.
7. The continuous sweat monitoring and insulin infusion based diabetes patient management system of claim 1, wherein: the sweat detection module, the data processing module and the communication module are manufactured into a flexible circuit board.
8. The continuous sweat monitoring and insulin infusion based diabetes patient management system of claim 1, wherein: the communication module adopts Bluetooth communication.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114732402A (en) * | 2022-05-11 | 2022-07-12 | 李益非 | Diabetes digital health management system based on big data |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114732402A (en) * | 2022-05-11 | 2022-07-12 | 李益非 | Diabetes digital health management system based on big data |
| CN114732402B (en) * | 2022-05-11 | 2022-10-25 | 中食安泓(广东)健康产业有限公司 | Diabetes digital health management system based on big data |
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