GB1497836A - Stabilized steroid formulations - Google Patents

Stabilized steroid formulations

Info

Publication number
GB1497836A
GB1497836A GB23485/75A GB2348575A GB1497836A GB 1497836 A GB1497836 A GB 1497836A GB 23485/75 A GB23485/75 A GB 23485/75A GB 2348575 A GB2348575 A GB 2348575A GB 1497836 A GB1497836 A GB 1497836A
Authority
GB
United Kingdom
Prior art keywords
polyethylene glycol
weight
stabilized
compositions
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23485/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1497836A publication Critical patent/GB1497836A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1497836 Stabilized steroid compositions ER SQUIBB & SONS INC 29 May 1975 [13 June 1974] 23485/75 Heading A5B Stabilized steroid compositions useful in the treatment of inflammatory diseases of the skin and psoriasis comprises from 0.1% to 0.5% by weight of 9 α - fluoro - 21 - chloro - 11#, 16α, 17α, trihydroxypregn - 4 - ene - 3, 20 - dione, 16, 17 - acetonide, 0.005 to 0.2% by weight of an antioxidant selected from propyl gallate, butylated hydroxytoluene, butylated hydroxyanisole, sodium bisulphite, sodium metabisulphite and ascorbic acid; and polyethylene glycol or a polyethylene glycol ester both having a polyethylene glycol molecular weight of from 200 to 7500 may be prepared by dissolving the steroid and antioxidant in the polyethylene glycol or polyethylene glycol ester. The composition may further include an oleaginous material e.g. mineral oil thickened with polyethylene or white petrolatum, a chelating agent such as disodium ethylene diamine tetraacetic acid and/or water. The compositions may be applied topically in the form of lotions or ointments.
GB23485/75A 1974-06-13 1975-05-29 Stabilized steroid formulations Expired GB1497836A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47898574A 1974-06-13 1974-06-13

Publications (1)

Publication Number Publication Date
GB1497836A true GB1497836A (en) 1978-01-12

Family

ID=23902198

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23485/75A Expired GB1497836A (en) 1974-06-13 1975-05-29 Stabilized steroid formulations

Country Status (11)

Country Link
JP (1) JPS5126216A (en)
BE (1) BE830239A (en)
CA (1) CA1040534A (en)
DE (1) DE2526251A1 (en)
FR (1) FR2274310A1 (en)
GB (1) GB1497836A (en)
IE (1) IE41417B1 (en)
NL (1) NL7506872A (en)
PH (1) PH14507A (en)
YU (1) YU152175A (en)
ZA (1) ZA753429B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156341A (en) * 1994-07-04 2000-12-05 Schering Aktiensgesellschaft Low-dosed steroid tablets that contain gallic acid ester as an antioxidant, process for production, and use
EP2047846A2 (en) * 2001-05-23 2009-04-15 Medicis Pharmaceutical Corporation Process for stabilizing hydroquinone
CN107427465A (en) * 2015-02-05 2017-12-01 马克·赛尔纳尔 Ionic nano vesicle suspension and the biocide from its preparation

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612306A (en) * 1979-07-12 1981-02-06 Nippon Zoki Pharmaceut Co Ltd Novel base for external preparation
JPS56135416A (en) * 1980-03-27 1981-10-22 Mitsubishi Chem Ind Ltd Pharmaceutical preparation for skin
DE102004059880A1 (en) * 2004-12-10 2006-06-14 Grünenthal GmbH Stable, hormone-containing (intermediate) product

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6156341A (en) * 1994-07-04 2000-12-05 Schering Aktiensgesellschaft Low-dosed steroid tablets that contain gallic acid ester as an antioxidant, process for production, and use
EP2047846A2 (en) * 2001-05-23 2009-04-15 Medicis Pharmaceutical Corporation Process for stabilizing hydroquinone
EP2047846A3 (en) * 2001-05-23 2009-04-29 Medicis Pharmaceutical Corporation Process for stabilizing hydroquinone
CN107427465A (en) * 2015-02-05 2017-12-01 马克·赛尔纳尔 Ionic nano vesicle suspension and the biocide from its preparation
EP3253370A4 (en) * 2015-02-05 2018-08-01 Marc Selner Ionic nanovesicle suspension and biocide prepared therefrom

Also Published As

Publication number Publication date
BE830239A (en) 1975-10-01
FR2274310B1 (en) 1980-05-16
CA1040534A (en) 1978-10-17
ZA753429B (en) 1976-04-28
AU8168175A (en) 1976-12-02
JPS5126216A (en) 1976-03-04
IE41417B1 (en) 1980-01-02
IE41417L (en) 1975-12-13
JPS5747971B2 (en) 1982-10-13
DE2526251A1 (en) 1976-01-02
PH14507A (en) 1981-08-21
FR2274310A1 (en) 1976-01-09
NL7506872A (en) 1975-12-16
YU152175A (en) 1983-10-31

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19950528