GB1497681A - Thiomethyl ergolene derivatives - Google Patents
Thiomethyl ergolene derivativesInfo
- Publication number
- GB1497681A GB1497681A GB9807/75A GB980775A GB1497681A GB 1497681 A GB1497681 A GB 1497681A GB 9807/75 A GB9807/75 A GB 9807/75A GB 980775 A GB980775 A GB 980775A GB 1497681 A GB1497681 A GB 1497681A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- formula
- group
- proviso
- heteroatoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1497681 6 - Methyl - 8 - mercaptomethylergolenes and ergolines SANDOZ Ltd 10 March 1975 [14 March 1974 23 July 1974] 9807/75 Heading C2 [Also in Division A5] Novel compounds of the Formula I wherein # is the group -CH = CH or and R is hydrogen; cyano; a 5- or 6-membered unsaturated heterocyclic radical attached through a ring carbon atom and having 1 to 3 heteroatoms, the first hetero atom being introgen, oxygen-or sulphur-and the second and third heteroatoms, if present, being nitrogen; or a 2- or 4-pyridyl monosubstituted by C 1-4 alkyl or alkoxy or chlorine, fluorine or bromine, with the proviso that when # is -CH=C< and the side chain in the 8 position has the #- configuration then R is other than 2-pyridyl, and acid addition salts thereof, may be prepared by reacting a compound of Formula II wherein X is a radical capable of being displaced by a thio group with a compound of the formula M5R wherein M is hydrogen or alkali metal or by reducing the -SCN group in a compound of the Formula I in which R is CN to -5N. 6 - Methyl - 8α - methanesulphonyloxymethyl ergoline-I is prepared by acrylation of 9,10- dihydro-isolysergol I with methane sulphonyl chloride. The compound I excluded by the proviso is the subject of Divisional Specification 1,497,682.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH356374A CH593972A5 (en) | 1974-03-14 | 1974-03-14 | |
| CH1013874 | 1974-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1497681A true GB1497681A (en) | 1978-01-12 |
Family
ID=25693324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9807/75A Expired GB1497681A (en) | 1974-03-14 | 1975-03-10 | Thiomethyl ergolene derivatives |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS589111B2 (en) |
| AU (1) | AU500890B2 (en) |
| CA (1) | CA1071192A (en) |
| DD (1) | DD118428A5 (en) |
| DE (1) | DE2509471A1 (en) |
| DK (1) | DK141701B (en) |
| ES (1) | ES435538A1 (en) |
| FI (1) | FI60865C (en) |
| FR (1) | FR2263774B1 (en) |
| GB (1) | GB1497681A (en) |
| HK (1) | HK8481A (en) |
| IE (1) | IE41533B1 (en) |
| IL (1) | IL46809A (en) |
| MY (1) | MY8100331A (en) |
| NL (1) | NL7502807A (en) |
| NO (1) | NO750748L (en) |
| PH (1) | PH12966A (en) |
| SE (1) | SE420094B (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030351A2 (en) * | 1979-12-06 | 1981-06-17 | FARMITALIA CARLO ERBA S.p.A. | Ergoline derivatives, their preparation and therapeutic composition containing them |
| FR2531433A1 (en) * | 1982-08-09 | 1984-02-10 | Sandoz Sa | NOVEL Rye ergot alkaloids, their preparation and their use as medicaments |
| GB2173699A (en) * | 1985-04-05 | 1986-10-22 | Poli Ind Chimica Spa | Pharmaceutical compositions with antilactational activity |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4147789A (en) * | 1974-03-14 | 1979-04-03 | Sandoz Ltd. | 6-Methyl-8-thiomethyl-ergolene derivatives |
| JPS5293797A (en) * | 1976-01-30 | 1977-08-06 | Sandoz Ag | Improvement in organic compound |
| GB1555751A (en) * | 1977-02-02 | 1979-11-14 | Farmaceutici Italia | Ergoline deritatives |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| GB2120242A (en) * | 1982-04-30 | 1983-11-30 | Erba Farmitalia | Ergoline derivatives |
| US4798834A (en) * | 1987-08-31 | 1989-01-17 | Eli Lilly And Company | Optionally substituted (3β-9,10-didehydro-2,3-dihydro ergoline as serotonergic function enhancement |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6818658A (en) * | 1968-01-18 | 1969-07-22 |
-
1975
- 1975-02-12 IE IE542/75A patent/IE41533B1/en unknown
- 1975-03-05 DK DK89375AA patent/DK141701B/en not_active IP Right Cessation
- 1975-03-05 DE DE19752509471 patent/DE2509471A1/en not_active Ceased
- 1975-03-05 SE SE7502469A patent/SE420094B/en unknown
- 1975-03-06 FI FI750644A patent/FI60865C/en not_active IP Right Cessation
- 1975-03-06 NO NO75750748A patent/NO750748L/no unknown
- 1975-03-10 NL NL7502807A patent/NL7502807A/en not_active Application Discontinuation
- 1975-03-10 GB GB9807/75A patent/GB1497681A/en not_active Expired
- 1975-03-11 FR FR7507472A patent/FR2263774B1/fr not_active Expired
- 1975-03-12 ES ES435538A patent/ES435538A1/en not_active Expired
- 1975-03-12 PH PH16903A patent/PH12966A/en unknown
- 1975-03-12 DD DD184721A patent/DD118428A5/xx unknown
- 1975-03-12 IL IL46809A patent/IL46809A/en unknown
- 1975-03-13 AU AU79057/75A patent/AU500890B2/en not_active Ceased
- 1975-03-13 JP JP50029600A patent/JPS589111B2/en not_active Expired
- 1975-03-13 CA CA221,971A patent/CA1071192A/en not_active Expired
-
1981
- 1981-03-12 HK HK84/81A patent/HK8481A/en unknown
- 1981-12-30 MY MY331/81A patent/MY8100331A/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030351A2 (en) * | 1979-12-06 | 1981-06-17 | FARMITALIA CARLO ERBA S.p.A. | Ergoline derivatives, their preparation and therapeutic composition containing them |
| EP0030351A3 (en) * | 1979-12-06 | 1981-12-02 | Farmitalia Carlo Erba S.P.A. | Ergoline derivatives, their preparation and therapeutic composition containing them |
| FR2531433A1 (en) * | 1982-08-09 | 1984-02-10 | Sandoz Sa | NOVEL Rye ergot alkaloids, their preparation and their use as medicaments |
| GB2173699A (en) * | 1985-04-05 | 1986-10-22 | Poli Ind Chimica Spa | Pharmaceutical compositions with antilactational activity |
Also Published As
| Publication number | Publication date |
|---|---|
| AU500890B2 (en) | 1979-06-07 |
| SE7502469L (en) | 1975-09-15 |
| MY8100331A (en) | 1981-12-31 |
| DD118428A5 (en) | 1976-03-05 |
| PH12966A (en) | 1979-10-19 |
| IE41533L (en) | 1975-09-14 |
| DK141701C (en) | 1980-10-20 |
| HK8481A (en) | 1981-03-20 |
| JPS589111B2 (en) | 1983-02-18 |
| AU7905775A (en) | 1976-09-16 |
| DK89375A (en) | 1975-09-15 |
| FR2263774A1 (en) | 1975-10-10 |
| IL46809A0 (en) | 1975-07-28 |
| DK141701B (en) | 1980-05-27 |
| CA1071192A (en) | 1980-02-05 |
| IL46809A (en) | 1978-04-30 |
| NL7502807A (en) | 1975-09-16 |
| JPS50123698A (en) | 1975-09-29 |
| DE2509471A1 (en) | 1975-09-18 |
| FI60865C (en) | 1982-04-13 |
| NO750748L (en) | 1975-09-16 |
| IE41533B1 (en) | 1980-01-30 |
| SE420094B (en) | 1981-09-14 |
| ES435538A1 (en) | 1977-03-16 |
| FI750644A (en) | 1975-09-15 |
| FI60865B (en) | 1981-12-31 |
| FR2263774B1 (en) | 1978-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SPA | Amended specification published | ||
| PCNP | Patent ceased through non-payment of renewal fee |