GB1496167A - Iodonium salts - Google Patents

Iodonium salts

Info

Publication number
GB1496167A
GB1496167A GB9465/77A GB946577A GB1496167A GB 1496167 A GB1496167 A GB 1496167A GB 9465/77 A GB9465/77 A GB 9465/77A GB 946577 A GB946577 A GB 946577A GB 1496167 A GB1496167 A GB 1496167A
Authority
GB
United Kingdom
Prior art keywords
radical
defined above
phenyl
methylthien
thienyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9465/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB9465/77A priority Critical patent/GB1496167A/en
Publication of GB1496167A publication Critical patent/GB1496167A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18—Polycyclic aromatic halogenated hydrocarbons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1496167 lodonium salts IMPERIAL CHEMICAL INDUSTRIES Ltd 9 Oct 1975 [30 Oct 1974 5 May 1975] 09465/77 and 9466/77 Divided out of 1496166 Heading C2C The invention comprises an iodonium salt of the formula R<SP>3</SP>R<SP>4</SP>I<SP>+</SP>.X<SP>-</SP> wherein: either R<SP>3</SP> is a 2-thienyl radical, optionally bearing one or more substituents selected from nitro, hydroxy and carboxy radicals, halogen atoms, alkyl, alkoxy and alkanoylamino radicals each of up to 6 carbon atoms, cycloalkyl radicals of 3 to 7 carbon atoms, and phenyliodonio and thienyliodonio radicals optionally bearing one or more substituents as defined above, and R<SP>4</SP> is a 2- thienyl radical substituted as defined above, a phenyl radical bearing three or more substituents as defined above or a naphthyl radical bearing one or more substituents as defined above; or R<SP>3</SP> is a 2-thienyl radical substituted as defined above and R<SP>4</SP> is a phenyl or naphthyl radical optionally substituted as defined above; or R<SP>3</SP> is a 3-thienyl radical optionally substituted as defined above and R<SP>4</SP> is a phenyl, naphthyl or thienyl radical optionally substituted as defined above; or R<SP>3</SP> is an unsubstituted phenyl radical and R<SP>4</SP> is a 3-methylthien-2-yl, 5- chlorothien - 2 - yl, 5 - methylthien - 2 - yl, 5- nitrothien - 2 - yl, 4 - cyclohexylphenyl or 4 - chloro - 2,5 - dimethylphenyl radical; or R<SP>3</SP> is a 4 - chlorophenyl radical and R<SP>4</SP> is a 3- methylthien - 2 - yl, 4 - fluorophenyl, 4 - tolyl, 4 - methoxy - 3 - nitrophenyl, 4 - s - butylphenyl, 2,4 - xylyl, mesityl, 2,3,4 - trimethylphenyl, 4 - bromophenyl, 2,4 - dimethoxyphenyl, 4 - chloro - 2,5 - dimethylphenyl, 4- acetamidophenyl or 4 - (4 - chlorophenyliodonio)phenyl radical; or R<SP>3</SP> is an unsubstituted 2-thienyl radical and R<SP>4</SP> is a 3-carboxyphenyl, 4 - (2 - thienyliodonio)phenyl, or 3 - (2- thienyliodonio)phenyl radical; or R<SP>3</SP> is a 4- fluorophenyl radical and R<SP>4</SP> is a 3-methylthien- 2 - yl, 4 - tolyl or 3 - nitrophenyl radical; or R<SP>3</SP> is a 4-tolyl radical and R<SP>4</SP> is a 4-cyclohexylphenyl radical; or R<SP>3</SP> is a 4 - methoxyphenyl radical and R<SP>4</SP> is a 3-(4-methoxyphenyliodonio)phenyl radical; or R<SP>3</SP> and R<SP>4</SP> are each a 5-methylthien-2-yl, 5-bromothien- 2-yl, 3 - bromothien - 2 - yl, 3 - methylthien- 2 - yl, 4 - chloro - 2,5 - dimethylphenyl, 4- chloro - 3 - methylphenyl, 4 - bromo - 2,5 - dimethylphenyl, or 4 - methoxy - 3 - nitrophenyl radical; and X<SP>-</SP> is a pharmaceutically acceptable anion. The compounds may be prepared, when R<SP>3</SP> and R<SP>4</SP> are the same, by reacting a compound of the formula R<SP>3</SP>H with iodoxyl sulphate, an alkali metal iodate in acetic anhydride and sulphuric acid, or an iodine tri(C 1-4 alkanoate), or, when R<SP>3</SP> and R<SP>4</SP> are the same or different, with a di(C 1-4 alkanoyloxy)iodo compound of the formula R<SP>4</SP>I(OR<SP>5</SP>) 2 where R<SP>5</SP> is a C 1-4 alkanoyl radical.
GB9465/77A 1975-10-09 1975-10-09 Iodonium salts Expired GB1496167A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB9465/77A GB1496167A (en) 1975-10-09 1975-10-09 Iodonium salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9465/77A GB1496167A (en) 1975-10-09 1975-10-09 Iodonium salts

Publications (1)

Publication Number Publication Date
GB1496167A true GB1496167A (en) 1977-12-30

Family

ID=9872502

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9465/77A Expired GB1496167A (en) 1975-10-09 1975-10-09 Iodonium salts

Country Status (1)

Country Link
GB (1) GB1496167A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131659B2 (en) 2014-04-07 2018-11-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10131659B2 (en) 2014-04-07 2018-11-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof
US10738047B2 (en) 2014-04-07 2020-08-11 The United States Of America, As Represented By The Secretary, Department Of Health Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee