GB1494462A - Phenoxyphenylbutyric acid derivatives and process for their preparation - Google Patents

Phenoxyphenylbutyric acid derivatives and process for their preparation

Info

Publication number
GB1494462A
GB1494462A GB8980/76A GB898076A GB1494462A GB 1494462 A GB1494462 A GB 1494462A GB 8980/76 A GB8980/76 A GB 8980/76A GB 898076 A GB898076 A GB 898076A GB 1494462 A GB1494462 A GB 1494462A
Authority
GB
United Kingdom
Prior art keywords
piperazino
alkyl
acid derivatives
chr
march
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8980/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of GB1494462A publication Critical patent/GB1494462A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

1494462 Phenoxyphenyl-butyric acid derivatives MERCK PATENT GmbH 5 March 1976 [7 March 1975] 08980/76 Heading C2C Novel compounds I in which R<SP>1</SP> is H, C 1-6 alkyl or C n H 2n -R<SP>3</SP>, R<SP>2</SP> is H, Cl, Br or F, R<SP>3</SP> is di(C 1-4 alkyl)amino, pyrrolidino, piperidino, morpholino, piperazino, N-C 1-4 alkyl-piperazino or N-C 1-4 hydroxyalkyl-piperazino and n is 2, 3 or 4, and their physiologically acceptable salts, are prepared by reducing a compound II and R<SP>5</SP> is -C(CH 3 )R<SP>6</SP>-CH 2 -, -C(CH 3 )=CH-, -C(=CH 2 )-CH 2 -, -CH(CH 3 )-CHR<SP>7</SP>-, -(CH 3 )R<SP>6</SP>-CHR<SP>7</SP> or -C(CH 3 )=CR<SP>7</SP>, where R<SP>6</SP> and R<SP>7</SP> are each OH, Oacyl, SH, NH 2 , aralkyloxy or aralkylamino, followed, if desired, by treatment of a resulting compound I with a solvolysing, esterifying or salt-forming agent. Pharmaceutical compositions having antiinflammatory, analgesic, antipyretic, antiarteriosclerotic and thrombocyte aggregationinhibiting activity for oral, parenteral, rectal or topical administration, comprise one of the above novel compounds together with a pharmaceutically acceptable carrier.
GB8980/76A 1975-03-07 1976-03-05 Phenoxyphenylbutyric acid derivatives and process for their preparation Expired GB1494462A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19752509891 DE2509891A1 (en) 1975-03-07 1975-03-07 PHENOXYPHENYL BUTTERIC ACID DERIVATIVES AND METHOD FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
GB1494462A true GB1494462A (en) 1977-12-07

Family

ID=5940676

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8980/76A Expired GB1494462A (en) 1975-03-07 1976-03-05 Phenoxyphenylbutyric acid derivatives and process for their preparation

Country Status (14)

Country Link
JP (1) JPS51125348A (en)
AT (1) ATA162476A (en)
AU (1) AU497104B2 (en)
BE (1) BE839211A (en)
DE (1) DE2509891A1 (en)
DK (1) DK97976A (en)
ES (1) ES445793A1 (en)
FR (1) FR2302731A1 (en)
GB (1) GB1494462A (en)
IE (1) IE42502B1 (en)
LU (1) LU74489A1 (en)
NL (1) NL7602341A (en)
SE (1) SE7602744L (en)
ZA (1) ZA761340B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6011483A (en) * 1983-06-29 1985-01-21 Taiho Yakuhin Kogyo Kk Piperazine compound

Also Published As

Publication number Publication date
NL7602341A (en) 1976-09-09
ES445793A1 (en) 1977-09-01
IE42502L (en) 1976-09-07
FR2302731A1 (en) 1976-10-01
LU74489A1 (en) 1977-09-27
BE839211A (en) 1976-09-06
SE7602744L (en) 1976-09-08
DK97976A (en) 1976-09-08
JPS51125348A (en) 1976-11-01
AU1155576A (en) 1977-09-08
IE42502B1 (en) 1980-08-27
ATA162476A (en) 1979-05-15
AU497104B2 (en) 1978-11-30
ZA761340B (en) 1977-02-23
DE2509891A1 (en) 1976-09-23

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee