GB1492073A - Pyrido(3,2-e)-as-triazine derivatives - Google Patents

Pyrido(3,2-e)-as-triazine derivatives

Info

Publication number
GB1492073A
GB1492073A GB32908/75A GB3290875A GB1492073A GB 1492073 A GB1492073 A GB 1492073A GB 32908/75 A GB32908/75 A GB 32908/75A GB 3290875 A GB3290875 A GB 3290875A GB 1492073 A GB1492073 A GB 1492073A
Authority
GB
United Kingdom
Prior art keywords
pyrido
hydrazides
acyl
alkyl
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB32908/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK356275AA priority Critical patent/DK138426B/en
Priority to SE7508834A priority patent/SE409456B/en
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to GB32908/75A priority patent/GB1492073A/en
Priority to FI752294A priority patent/FI59098C/en
Priority to AT636675A priority patent/AT347958B/en
Priority to DE19752536387 priority patent/DE2536387A1/en
Priority to CH1064575A priority patent/CH617199A5/en
Priority to DD187881A priority patent/DD121323A5/xx
Priority to JP50099878A priority patent/JPS5225796A/en
Priority to BE159502A priority patent/BE832791A/en
Publication of GB1492073A publication Critical patent/GB1492073A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77—Hydrazine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1492073 Pyrido-[3,2-e]-as-triazines EGYT GYOGYSZERVEGYESZETI GYAR 6 Aug 1975 32908/75 Heading C2C The invention comprises compounds of Formula (I) and their pharmaceutically acceptable salts, wherein R is C 5-20 alkyl, Ph (optionally substituted by halogen, OH, NH 2 or by # 1 alkoxy) or Ph-C 1-4 -alkyl and either R 1 = R 2 = H (Ia) or R 1 -R 2 constitutes a further N-N bond (Ib). In examples, (Ia) are prepared by cyclizing the corresponding N<SP>1</SP>-acyl-N<SP>2</SP>-(3-aminopyrid-2-yl) hydrazides, and may be oxidized to (Ib). Also prepared are N<SP>1</SP>-acyl-N<SP>2</SP>-(3-nitropyrid-2-yl) hydrazides. Therapeutic compositions having antibacterial, antifungal, antiinflammatory and/or antimicrobial activity comprise compounds of the above formula.
GB32908/75A 1975-08-05 1975-08-06 Pyrido(3,2-e)-as-triazine derivatives Expired GB1492073A (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK356275AA DK138426B (en) 1975-08-05 1975-08-05 Analogous process for the preparation of pyrido (3,2-e) -as-triazine derivatives.
SE7508834A SE409456B (en) 1975-08-05 1975-08-05 ANALOGICAL PROCEDURE FOR THE PREPARATION OF PYRIDO (3,2-E) -AS-TRIAZINE DERIVATIVES
GB32908/75A GB1492073A (en) 1975-08-05 1975-08-06 Pyrido(3,2-e)-as-triazine derivatives
FI752294A FI59098C (en) 1975-08-05 1975-08-13 FRAME FOR THE PREPARATION OF THERAPEUTIC ANIMAL THERMAL PYRIDO (3,2-E) -ASTRIAZINDERIVAT
DE19752536387 DE2536387A1 (en) 1975-08-05 1975-08-14 PYRIDO (3,2-E) -AS-TRIAZINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING SUCH, AND METHOD FOR MANUFACTURING THE SAME
AT636675A AT347958B (en) 1975-08-05 1975-08-14 PROCESS FOR THE PREPARATION OF NEW PYRIDO (3.2-E) -AS-TRIAZINE DERIVATIVES AND OF SALT OF THESE COMPOUNDS, FORMED WITH PHARMACEUTICAL ACIDS
CH1064575A CH617199A5 (en) 1975-08-05 1975-08-15 Process for the preparation of pyrido[3,2-e]-as-triazine derivatives
DD187881A DD121323A5 (en) 1975-08-05 1975-08-15
JP50099878A JPS5225796A (en) 1975-08-05 1975-08-19 Production of pyrid *3*22e* asstriazine derivative
BE159502A BE832791A (en) 1975-08-05 1975-08-27 DERIVATIVES OF PYRIDO (3,2-E) -AS-TRIAZINE AND PROCESS FOR THEIR PREPARATION.

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
DK356275AA DK138426B (en) 1975-08-05 1975-08-05 Analogous process for the preparation of pyrido (3,2-e) -as-triazine derivatives.
SE7508834A SE409456B (en) 1975-08-05 1975-08-05 ANALOGICAL PROCEDURE FOR THE PREPARATION OF PYRIDO (3,2-E) -AS-TRIAZINE DERIVATIVES
GB32908/75A GB1492073A (en) 1975-08-05 1975-08-06 Pyrido(3,2-e)-as-triazine derivatives
FI752294A FI59098C (en) 1975-08-05 1975-08-13 FRAME FOR THE PREPARATION OF THERAPEUTIC ANIMAL THERMAL PYRIDO (3,2-E) -ASTRIAZINDERIVAT
DE19752536387 DE2536387A1 (en) 1975-08-05 1975-08-14 PYRIDO (3,2-E) -AS-TRIAZINE DERIVATIVES, MEDICINAL PRODUCTS CONTAINING SUCH, AND METHOD FOR MANUFACTURING THE SAME
AT636675A AT347958B (en) 1975-08-05 1975-08-14 PROCESS FOR THE PREPARATION OF NEW PYRIDO (3.2-E) -AS-TRIAZINE DERIVATIVES AND OF SALT OF THESE COMPOUNDS, FORMED WITH PHARMACEUTICAL ACIDS
CH1064575A CH617199A5 (en) 1975-08-05 1975-08-15 Process for the preparation of pyrido[3,2-e]-as-triazine derivatives
DD187881A DD121323A5 (en) 1975-08-05 1975-08-15
JP50099878A JPS5225796A (en) 1975-08-05 1975-08-19 Production of pyrid *3*22e* asstriazine derivative
BE159502A BE832791A (en) 1975-08-05 1975-08-27 DERIVATIVES OF PYRIDO (3,2-E) -AS-TRIAZINE AND PROCESS FOR THEIR PREPARATION.

Publications (1)

Publication Number Publication Date
GB1492073A true GB1492073A (en) 1977-11-16

Family

ID=27578944

Family Applications (1)

Application Number Title Priority Date Filing Date
GB32908/75A Expired GB1492073A (en) 1975-08-05 1975-08-06 Pyrido(3,2-e)-as-triazine derivatives

Country Status (10)

Country Link
JP (1) JPS5225796A (en)
AT (1) AT347958B (en)
BE (1) BE832791A (en)
CH (1) CH617199A5 (en)
DD (1) DD121323A5 (en)
DE (1) DE2536387A1 (en)
DK (1) DK138426B (en)
FI (1) FI59098C (en)
GB (1) GB1492073A (en)
SE (1) SE409456B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159112A1 (en) * 1984-02-21 1985-10-23 Eli Lilly And Company Process for the preparation of diaminopyridines
WO2024094150A1 (en) * 2022-11-04 2024-05-10 Insilico Medicine Ip Limited Nlrp3 inflammasome inhibitors and uses thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU764272B2 (en) * 1998-12-01 2003-08-14 Bayer Aktiengesellschaft Substituted 1,3,5-triazines

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0159112A1 (en) * 1984-02-21 1985-10-23 Eli Lilly And Company Process for the preparation of diaminopyridines
WO2024094150A1 (en) * 2022-11-04 2024-05-10 Insilico Medicine Ip Limited Nlrp3 inflammasome inhibitors and uses thereof

Also Published As

Publication number Publication date
DK356275A (en) 1977-02-06
FI59098C (en) 1981-06-10
ATA636675A (en) 1978-06-15
DE2536387A1 (en) 1977-02-24
DD121323A5 (en) 1976-07-20
JPS5225796A (en) 1977-02-25
SE7508834L (en) 1977-02-06
DK138426B (en) 1978-09-04
SE409456B (en) 1979-08-20
DK138426C (en) 1979-02-12
FI752294A (en) 1977-02-14
AT347958B (en) 1979-01-25
BE832791A (en) 1975-12-16
FI59098B (en) 1981-02-27
CH617199A5 (en) 1980-05-14

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee