GB1480850A - Enzymatic hydrolysis and synthesis - Google Patents
Enzymatic hydrolysis and synthesisInfo
- Publication number
- GB1480850A GB1480850A GB54336/74A GB5433674A GB1480850A GB 1480850 A GB1480850 A GB 1480850A GB 54336/74 A GB54336/74 A GB 54336/74A GB 5433674 A GB5433674 A GB 5433674A GB 1480850 A GB1480850 A GB 1480850A
- Authority
- GB
- United Kingdom
- Prior art keywords
- synthesis
- cephalosporin
- acid
- aca
- reacted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 7
- 238000003786 synthesis reaction Methods 0.000 title abstract 7
- 230000007071 enzymatic hydrolysis Effects 0.000 title abstract 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 title abstract 2
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 abstract 5
- 229930186147 Cephalosporin Natural products 0.000 abstract 5
- 229940124587 cephalosporin Drugs 0.000 abstract 5
- 150000001780 cephalosporins Chemical class 0.000 abstract 5
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 abstract 4
- NVIAYEIXYQCDAN-CLZZGJSISA-N 7beta-aminodeacetoxycephalosporanic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)[C@@H](N)[C@@H]12 NVIAYEIXYQCDAN-CLZZGJSISA-N 0.000 abstract 3
- 241000534944 Thia Species 0.000 abstract 3
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 229940056360 penicillin g Drugs 0.000 abstract 2
- 239000008363 phosphate buffer Substances 0.000 abstract 2
- IKWLIQXIPRUIDU-ZCFIWIBFSA-N (6r)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound OC(=O)C1=CCS[C@@H]2CC(=O)N12 IKWLIQXIPRUIDU-ZCFIWIBFSA-N 0.000 abstract 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NVIAYEIXYQCDAN-UHFFFAOYSA-N 7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)C(N)C12 NVIAYEIXYQCDAN-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 108010073038 Penicillin Amidase Proteins 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- FUBBGQLTSCSAON-PBFPGSCMSA-N cefaloglycin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)COC(=O)C)C(O)=O)=CC=CC=C1 FUBBGQLTSCSAON-PBFPGSCMSA-N 0.000 abstract 1
- 229950004030 cefaloglycin Drugs 0.000 abstract 1
- ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 abstract 1
- 229940106164 cephalexin Drugs 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004494 ethyl ester group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT5448473 | 1973-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1480850A true GB1480850A (en) | 1977-07-27 |
Family
ID=11287332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB54336/74A Expired GB1480850A (en) | 1973-12-20 | 1974-12-16 | Enzymatic hydrolysis and synthesis |
Country Status (18)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100393A (en) * | 1996-03-15 | 2000-08-08 | Antibioticos, S.A. | Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5310156B2 (enrdf_load_stackoverflow) * | 1972-10-21 | 1978-04-11 | ||
| JPS52118A (en) * | 1975-06-23 | 1977-01-05 | Sony Corp | Still picture reproducing device |
-
1974
- 1974-11-28 IL IL46150A patent/IL46150A/xx unknown
- 1974-12-05 AU AU76089/74A patent/AU7608974A/en not_active Expired
- 1974-12-11 ZA ZA00747895A patent/ZA747895B/xx unknown
- 1974-12-12 FR FR7440980A patent/FR2255380B1/fr not_active Expired
- 1974-12-16 GB GB54336/74A patent/GB1480850A/en not_active Expired
- 1974-12-16 BE BE151538A patent/BE823392A/xx not_active IP Right Cessation
- 1974-12-17 YU YU03356/74A patent/YU335674A/xx unknown
- 1974-12-17 LU LU71506A patent/LU71506A1/xx unknown
- 1974-12-18 DD DD183150A patent/DD116833A5/xx unknown
- 1974-12-18 DK DK660374A patent/DK660374A/da not_active Application Discontinuation
- 1974-12-18 NL NL7416549A patent/NL7416549A/xx active Search and Examination
- 1974-12-19 NO NO744590A patent/NO744590L/no unknown
- 1974-12-19 HU HU74SA00002731A patent/HU172077B/hu unknown
- 1974-12-19 CA CA216,466A patent/CA1018091A/en not_active Expired
- 1974-12-19 SE SE7416077A patent/SE7416077L/xx unknown
- 1974-12-20 DE DE19742460607 patent/DE2460607A1/de active Pending
- 1974-12-20 CS CS748821A patent/CS209853B2/cs unknown
- 1974-12-20 JP JP49145850A patent/JPS5095486A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100393A (en) * | 1996-03-15 | 2000-08-08 | Antibioticos, S.A. | Process for purifying 7-substituted aminodeacetoxy-cephalosporins through the use of filtration membranes |
Also Published As
| Publication number | Publication date |
|---|---|
| YU335674A (en) | 1982-05-31 |
| SE7416077L (enrdf_load_stackoverflow) | 1975-06-23 |
| FR2255380A1 (enrdf_load_stackoverflow) | 1975-07-18 |
| LU71506A1 (enrdf_load_stackoverflow) | 1975-06-17 |
| NO744590L (enrdf_load_stackoverflow) | 1975-07-14 |
| BE823392A (fr) | 1975-04-16 |
| IL46150A0 (en) | 1975-02-10 |
| ZA747895B (en) | 1976-01-28 |
| IL46150A (en) | 1979-07-25 |
| DE2460607A1 (de) | 1975-06-26 |
| AU7608974A (en) | 1976-06-10 |
| JPS5095486A (enrdf_load_stackoverflow) | 1975-07-29 |
| DD116833A5 (enrdf_load_stackoverflow) | 1975-12-12 |
| CA1018091A (en) | 1977-09-27 |
| DK660374A (enrdf_load_stackoverflow) | 1975-08-25 |
| FR2255380B1 (enrdf_load_stackoverflow) | 1977-11-10 |
| CS209853B2 (en) | 1981-12-31 |
| NL7416549A (nl) | 1975-06-24 |
| HU172077B (hu) | 1978-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |