GB1478240A - Gentamicin derivatives - Google Patents

Gentamicin derivatives

Info

Publication number
GB1478240A
GB1478240A GB2294675A GB2294675A GB1478240A GB 1478240 A GB1478240 A GB 1478240A GB 2294675 A GB2294675 A GB 2294675A GB 2294675 A GB2294675 A GB 2294675A GB 1478240 A GB1478240 A GB 1478240A
Authority
GB
United Kingdom
Prior art keywords
gentamicin
always equal
correspondent
active ingredient
amino groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2294675A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Hosbon SA
Original Assignee
Laboratorios Hosbon SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Hosbon SA filed Critical Laboratorios Hosbon SA
Publication of GB1478240A publication Critical patent/GB1478240A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

1478240 Antibiotic gentamicin alkylsulphates LABORATORIOS HOSBON SA 23 May 1975 [29 May 1974] 22946/75 Heading ASB [Also in Division C2] Pharmaceutical compositions having antibiotic activity comprise, as active ingredient, a gentamicin alkylsulphate of the general formula wherein d + e = m, R is H, R' is methyl, G is the remainder of a molecule of gentamicin, a = 6-10, n = 1 to a value equal to the number of amino groups of the correspondent gentamicin, m = 0 to a value lower in one unity to the maximum value of n, n + m being always equal to 4 or 5 according to the total number of amino groups of the correspondent gentamicin, b and c are 0 to n, b + c being always equal to n, and d and e are 0 to m, d + e being always equal to m, together with an inert solvent or excipient and may be administered parenterally or topically, e.g. as solutions, suspensions, creams, pomades or lotions. Additional possible active ingredient include lidocaine hydrochloride.
GB2294675A 1974-05-29 1975-05-23 Gentamicin derivatives Expired GB1478240A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7418556A FR2272680B1 (en) 1974-05-29 1974-05-29

Publications (1)

Publication Number Publication Date
GB1478240A true GB1478240A (en) 1977-06-29

Family

ID=9139390

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2294675A Expired GB1478240A (en) 1974-05-29 1975-05-23 Gentamicin derivatives

Country Status (7)

Country Link
BE (1) BE821600A (en)
DE (2) DE2446640A1 (en)
ES (1) ES438364A1 (en)
FR (1) FR2272680B1 (en)
GB (1) GB1478240A (en)
LU (1) LU72590A1 (en)
NL (1) NL7506362A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243258A1 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Production of a preparation comprising one or more antibiotics
EP1243255A2 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Method of preparation of antibiotic compositions
EP1287818A1 (en) * 2001-08-31 2003-03-05 Heraeus Kulzer GmbH & Co.KG Methods of antibiotic coating of objects having interconnected microcavities and the uses thereof

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10114244A1 (en) 2001-03-22 2002-10-02 Heraeus Kulzer Gmbh & Co Kg Antibiotic / antibiotic preparation with active ingredient release
IS6389A (en) 2001-08-31 2003-03-03 Heraeus Kulzer Gmbh & Co. Kg Experiences of antibiotic coating of carcasses containing microspheres, and also of such coated carcasses and their use
DE10227938B4 (en) 2002-06-21 2006-07-20 Heraeus Kulzer Gmbh Pharmaceutical preparation, process for its preparation and its use
DE10227935B4 (en) 2002-06-21 2007-10-04 Heraeus Kulzer Gmbh Process for the preparation of an antibiotic coating of porous bodies and use

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1243258A1 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Production of a preparation comprising one or more antibiotics
EP1243255A2 (en) * 2001-03-22 2002-09-25 Heraeus Kulzer GmbH & Co.KG Method of preparation of antibiotic compositions
EP1243255A3 (en) * 2001-03-22 2002-12-18 Heraeus Kulzer GmbH & Co.KG Method of preparation of antibiotic compositions
US6942877B2 (en) 2001-03-22 2005-09-13 Heraeus Kulzer Gmbh & Co. Kg Method for producing antibiotic composites
EP1287818A1 (en) * 2001-08-31 2003-03-05 Heraeus Kulzer GmbH & Co.KG Methods of antibiotic coating of objects having interconnected microcavities and the uses thereof
US6984410B2 (en) 2001-08-31 2006-01-10 Heraeus Kulzer Gmbh & Co. Kg Process for antibiotic coating of elements with interconnecting microcavities, elements thus coated as well as their usage
CZ301740B6 (en) * 2001-08-31 2010-06-09 Heraeus Kulzer Gmbh & Co. Kg Process for antibiotic coating of elements with interconnected microcavities

Also Published As

Publication number Publication date
LU72590A1 (en) 1975-10-08
FR2272680B1 (en) 1978-07-21
NL7506362A (en) 1975-12-02
DE2446640A1 (en) 1975-12-11
BE821600A (en) 1975-02-17
FR2272680A1 (en) 1975-12-26
ES438364A1 (en) 1977-01-16
DE2517600A1 (en) 1975-12-18

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee