GB1475459A - Production of triazolobenzodiazepines and intermediates therefor - Google Patents
Production of triazolobenzodiazepines and intermediates thereforInfo
- Publication number
- GB1475459A GB1475459A GB2474075A GB2474075A GB1475459A GB 1475459 A GB1475459 A GB 1475459A GB 2474075 A GB2474075 A GB 2474075A GB 2474075 A GB2474075 A GB 2474075A GB 1475459 A GB1475459 A GB 1475459A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- compounds
- prepared
- image
- benzophenone compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000543 intermediate Substances 0.000 title 1
- -1 pyrrolidino, piperidino, 4-methylpiperazino Chemical group 0.000 abstract 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical compound C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 abstract 1
- RHZBRCQIKQUQHQ-UHFFFAOYSA-N 2-(1,3-dioxoisoindol-2-yl)acetyl chloride Chemical compound C1=CC=C2C(=O)N(CC(=O)Cl)C(=O)C2=C1 RHZBRCQIKQUQHQ-UHFFFAOYSA-N 0.000 abstract 1
- BXBSDHSVTCGOFC-UHFFFAOYSA-N 3-amino-4-phenylquinazolin-4-ol Chemical compound NN1C=NC2=CC=CC=C2C1(O)C1=CC=CC=C1 BXBSDHSVTCGOFC-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- QGFWCHALBSZAQV-UHFFFAOYSA-N NCN1NN=C2C1=C1C(=C(C=CN=N1)C1=CC=CC=C1)C=C2 Chemical class NCN1NN=C2C1=C1C(=C(C=CN=N1)C1=CC=CC=C1)C=C2 QGFWCHALBSZAQV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical class C(C)(=O)* 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 239000012965 benzophenone Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/480,979 US3957761A (en) | 1973-02-14 | 1974-06-19 | Process for the production of 1-aminomethyl-6-phenyl-4h-s-triazolo-[4,3-a][1]benzodiazepines and intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1475459A true GB1475459A (en) | 1977-06-01 |
Family
ID=23910093
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2474075A Expired GB1475459A (en) | 1974-06-19 | 1975-06-10 | Production of triazolobenzodiazepines and intermediates therefor |
| GB4891776A Expired GB1475460A (en) | 1974-06-19 | 1975-06-10 | Production of triazolobenzodiazepines |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4891776A Expired GB1475460A (en) | 1974-06-19 | 1975-06-10 | Production of triazolobenzodiazepines |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5116695A (enrdf_load_stackoverflow) |
| BE (1) | BE830430A (enrdf_load_stackoverflow) |
| CA (1) | CA1055490A (enrdf_load_stackoverflow) |
| CH (1) | CH613206A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2526380A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2275467A1 (enrdf_load_stackoverflow) |
| GB (2) | GB1475459A (enrdf_load_stackoverflow) |
| NL (1) | NL7507295A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4194049A (en) * | 1979-03-29 | 1980-03-18 | Hoffmann-La Roche Inc. | 2-[[2-Methyl-1-[2-benzoyl(or benzyl)phenyl]-1H-imidazol-5-yl]methyl]-1H-isoindole-1,3(2H)-diones |
| US4474699A (en) * | 1983-05-25 | 1984-10-02 | The Upjohn Company | Preparing 1-aminomethyl-6-substituted-4H-s-triazolo[4,3-a][1,4]benzodiazepines in improved procedures |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT283368B (de) * | 1966-09-12 | 1970-08-10 | Dresden Arzneimittel | Verfahren zur herstellung von 1,4-benzodiazepinen |
| JPS4932874B1 (enrdf_load_stackoverflow) * | 1970-12-11 | 1974-09-03 |
-
1975
- 1975-05-22 CA CA227,597A patent/CA1055490A/en not_active Expired
- 1975-06-06 JP JP6769775A patent/JPS5116695A/ja active Granted
- 1975-06-09 CH CH743375A patent/CH613206A5/xx not_active IP Right Cessation
- 1975-06-10 GB GB2474075A patent/GB1475459A/en not_active Expired
- 1975-06-10 GB GB4891776A patent/GB1475460A/en not_active Expired
- 1975-06-13 DE DE19752526380 patent/DE2526380A1/de active Granted
- 1975-06-18 FR FR7519139A patent/FR2275467A1/fr active Granted
- 1975-06-19 NL NL7507295A patent/NL7507295A/xx not_active Application Discontinuation
- 1975-06-19 BE BE157498A patent/BE830430A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CH613206A5 (en) | 1979-09-14 |
| DE2526380C2 (enrdf_load_stackoverflow) | 1987-12-17 |
| NL7507295A (nl) | 1975-12-23 |
| FR2275467B1 (enrdf_load_stackoverflow) | 1978-09-22 |
| BE830430A (fr) | 1975-12-19 |
| CA1055490A (en) | 1979-05-29 |
| JPS6242910B2 (enrdf_load_stackoverflow) | 1987-09-10 |
| AU8156575A (en) | 1976-12-02 |
| GB1475460A (en) | 1977-06-01 |
| DE2526380A1 (de) | 1976-01-08 |
| JPS5116695A (ja) | 1976-02-10 |
| FR2275467A1 (fr) | 1976-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 704A | Declaration that licence is not available as of right for an excepted use (par. 4a/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940610 |