GB1472864A - Method of preparing cephalosporins - Google Patents
Method of preparing cephalosporinsInfo
- Publication number
- GB1472864A GB1472864A GB1424175A GB1424175A GB1472864A GB 1472864 A GB1472864 A GB 1472864A GB 1424175 A GB1424175 A GB 1424175A GB 1424175 A GB1424175 A GB 1424175A GB 1472864 A GB1472864 A GB 1472864A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formula
- heterocyclic ring
- derivatives
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 150000001780 cephalosporins Chemical class 0.000 title abstract 3
- -1 t-butoxy, benzyloxy, cyanomethyl Chemical group 0.000 abstract 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 239000002585 base Substances 0.000 abstract 3
- 229910052751 metal Inorganic materials 0.000 abstract 3
- 239000002184 metal Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- ATTZFSUZZUNHBP-UHFFFAOYSA-N Piperonyl sulfoxide Chemical compound CCCCCCCCS(=O)C(C)CC1=CC=C2OCOC2=C1 ATTZFSUZZUNHBP-UHFFFAOYSA-N 0.000 abstract 1
- QQIRAVWVGBTHMJ-UHFFFAOYSA-N [dimethyl-(trimethylsilylamino)silyl]methane;lithium Chemical compound [Li].C[Si](C)(C)N[Si](C)(C)C QQIRAVWVGBTHMJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 229910000102 alkali metal hydride Inorganic materials 0.000 abstract 1
- 150000008046 alkali metal hydrides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 abstract 1
- 125000004923 naphthylmethyl group Chemical group C1(=CC=CC2=CC=CC=C12)C* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000002902 organometallic compounds Chemical class 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 abstract 1
- 125000006007 trichloroethoxy group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/08—Preparation by forming the ring or condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1424175A GB1472864A (en) | 1975-04-05 | 1975-04-05 | Method of preparing cephalosporins |
| NLAANVRAGE7603264,A NL172544C (nl) | 1975-04-05 | 1976-03-29 | Werkwijze voor het bereiden van een 7-fenoxyacetylamino- 3-hydroxymethylcefem-4-carbonzuurderivaat. |
| YU00829/76A YU82976A (en) | 1975-04-05 | 1976-03-31 | Process for obtaining cephalosporin |
| DE2613641A DE2613641C2 (de) | 1975-04-05 | 1976-03-31 | Verfahren zur Herstellung von Cephalosporinen |
| FR7609284A FR2306207A1 (fr) | 1975-04-05 | 1976-03-31 | Nouveaux composes de la cephalosporine et leur procede de preparation |
| US05/672,527 US4035362A (en) | 1975-04-05 | 1976-03-31 | Methods for preparing cephalosporins |
| AU12568/76A AU499604B2 (en) | 1975-04-05 | 1976-04-01 | Synthesis of cephalosporins |
| CH764166A CH608810A5 (enExample) | 1975-04-05 | 1976-04-02 | |
| DK160776A DK160776A (da) | 1975-04-05 | 1976-04-02 | Fremgangsmade til fremstilling af cephalosporiner |
| SE7603960A SE428691B (sv) | 1975-04-05 | 1976-04-02 | Nytt forfarande for framstellning av cefalosporiner |
| BE165799A BE840329A (fr) | 1975-04-05 | 1976-04-02 | Nouveaux composes de la cephalosporine et leur procede de preparation |
| AT238176A AT342200B (de) | 1975-04-05 | 1976-04-02 | Verfahren zur herstellung von cephalosporinen |
| ZA761993A ZA761993B (en) | 1975-04-05 | 1976-04-02 | Method of preparing cephalosporins |
| MX000139U MX3329E (es) | 1975-04-05 | 1976-04-02 | Procedimiento para la preparacion de cefalosporinas |
| NO761141A NO150883C (no) | 1975-04-05 | 1976-04-02 | Fremgangsmaate for fremstilling av cefalosporiner |
| ES446673A ES446673A1 (es) | 1975-04-05 | 1976-04-03 | Un procedimiento para la preparacion de cefalosporinas. |
| JP51036722A JPS51122089A (en) | 1975-04-05 | 1976-04-03 | Production of cephalosporin |
| CA249,604A CA1060433A (en) | 1975-04-05 | 1976-04-05 | Process for the preparation of cephalosporins |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1424175A GB1472864A (en) | 1975-04-05 | 1975-04-05 | Method of preparing cephalosporins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1472864A true GB1472864A (en) | 1977-05-11 |
Family
ID=10037590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1424175A Expired GB1472864A (en) | 1975-04-05 | 1975-04-05 | Method of preparing cephalosporins |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4035362A (enExample) |
| JP (1) | JPS51122089A (enExample) |
| AT (1) | AT342200B (enExample) |
| AU (1) | AU499604B2 (enExample) |
| BE (1) | BE840329A (enExample) |
| CA (1) | CA1060433A (enExample) |
| CH (1) | CH608810A5 (enExample) |
| DE (1) | DE2613641C2 (enExample) |
| DK (1) | DK160776A (enExample) |
| ES (1) | ES446673A1 (enExample) |
| FR (1) | FR2306207A1 (enExample) |
| GB (1) | GB1472864A (enExample) |
| MX (1) | MX3329E (enExample) |
| NL (1) | NL172544C (enExample) |
| NO (1) | NO150883C (enExample) |
| SE (1) | SE428691B (enExample) |
| YU (1) | YU82976A (enExample) |
| ZA (1) | ZA761993B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3265390D1 (en) * | 1981-05-19 | 1985-09-19 | Ciba Geigy Ag | Process for the preparation of 4-thio-azetidinone compounds |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR6915080D0 (pt) * | 1969-06-12 | 1973-03-08 | Lilly Co Eli | Processo para a preparacao de um produto rearranjado de penicilina |
| BE787618A (fr) * | 1971-08-17 | 1973-02-16 | Gist Brocades Nv | Procede pour preparer des composes heterocycliques |
| US3962277A (en) * | 1973-02-09 | 1976-06-08 | Gist-Brocades N.V. | Acetidine derivatives |
| GB1465893A (en) * | 1973-02-09 | 1977-03-02 | Gist Brocades Nv | I-carboxypropenyl-4-iminothio-azetidine-2-one derivatives methods for their preparation and use |
| GB1472866A (en) * | 1974-06-12 | 1977-05-11 | Farmaceutici Italia | Cephalosporins and intermediates therefor |
-
1975
- 1975-04-05 GB GB1424175A patent/GB1472864A/en not_active Expired
-
1976
- 1976-03-29 NL NLAANVRAGE7603264,A patent/NL172544C/xx not_active IP Right Cessation
- 1976-03-31 FR FR7609284A patent/FR2306207A1/fr active Granted
- 1976-03-31 YU YU00829/76A patent/YU82976A/xx unknown
- 1976-03-31 DE DE2613641A patent/DE2613641C2/de not_active Expired
- 1976-03-31 US US05/672,527 patent/US4035362A/en not_active Expired - Lifetime
- 1976-04-01 AU AU12568/76A patent/AU499604B2/en not_active Expired
- 1976-04-02 SE SE7603960A patent/SE428691B/xx unknown
- 1976-04-02 ZA ZA761993A patent/ZA761993B/xx unknown
- 1976-04-02 DK DK160776A patent/DK160776A/da not_active IP Right Cessation
- 1976-04-02 MX MX000139U patent/MX3329E/es unknown
- 1976-04-02 CH CH764166A patent/CH608810A5/xx not_active IP Right Cessation
- 1976-04-02 AT AT238176A patent/AT342200B/de not_active IP Right Cessation
- 1976-04-02 BE BE165799A patent/BE840329A/xx not_active IP Right Cessation
- 1976-04-02 NO NO761141A patent/NO150883C/no unknown
- 1976-04-03 JP JP51036722A patent/JPS51122089A/ja active Pending
- 1976-04-03 ES ES446673A patent/ES446673A1/es not_active Expired
- 1976-04-05 CA CA249,604A patent/CA1060433A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2306207A1 (fr) | 1976-10-29 |
| US4035362A (en) | 1977-07-12 |
| SE7603960L (sv) | 1976-10-06 |
| AU499604B2 (en) | 1979-04-26 |
| FR2306207B1 (enExample) | 1979-04-20 |
| CA1060433A (en) | 1979-08-14 |
| BE840329A (fr) | 1976-10-04 |
| AU1256876A (en) | 1977-10-06 |
| NL7603264A (nl) | 1976-10-07 |
| AT342200B (de) | 1978-03-28 |
| NL172544C (nl) | 1983-09-16 |
| ZA761993B (en) | 1977-03-30 |
| NO150883C (no) | 1985-01-09 |
| JPS51122089A (en) | 1976-10-25 |
| CH608810A5 (enExample) | 1979-01-31 |
| YU82976A (en) | 1982-06-30 |
| MX3329E (es) | 1980-09-29 |
| DE2613641C2 (de) | 1982-12-23 |
| NL172544B (nl) | 1983-04-18 |
| SE428691B (sv) | 1983-07-18 |
| NO150883B (no) | 1984-09-24 |
| ATA238176A (de) | 1977-07-15 |
| NO761141L (enExample) | 1976-10-06 |
| DE2613641A1 (de) | 1976-10-21 |
| DK160776A (da) | 1976-10-06 |
| ES446673A1 (es) | 1977-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |