GB1471012A - Diphenyl ethers - Google Patents

Diphenyl ethers

Info

Publication number
GB1471012A
GB1471012A GB3838574A GB3838574A GB1471012A GB 1471012 A GB1471012 A GB 1471012A GB 3838574 A GB3838574 A GB 3838574A GB 3838574 A GB3838574 A GB 3838574A GB 1471012 A GB1471012 A GB 1471012A
Authority
GB
United Kingdom
Prior art keywords
hydrogen atom
hydrogen
diphenyl ethers
choh
sept
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3838574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23557898&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1471012(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1471012A publication Critical patent/GB1471012A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/075Ethers or acetals
    • A61K31/085Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/12Ketones
    • A61K31/122Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125Camphor; Nuclear substituted derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/257Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/295Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1471012 Diphenyl ethers SANDOZ Ltd 3 Sept 1974 [4 Sept 1973] 38385/74 Heading C2C Diphenyl ethers of the general formula wherein W is CO or CHOH, each of R and R 4 is a hydrogen, fluorine or chlorine atom or a C 1-4 alkyl group, R 1 is a branched C 3-5 alkyl group and each of R 2 and R 3 is a hydrogen, fluorine or chlorine atom or a C 1-4 alkyl or C 1-4 alkoxy group, which are novel provided that (i) when each of R, R 2 , R 3 and R 4 is a hydrogen atom, then R 1 is other than -C(CH 3 ) 3 , (ii) when each of R, R 2 , R 3 and R 4 is a hydrogen atom and W is CO, then R 1 is other than -CH(CH 3 ) 2 or -(CH 2 ) 2 CH(CH 3 ) 2 and (iii) when one of R 2 and R 3 is CH 3 O- in the 4- position and the other is a hydrogen atom, each of R and R 4 is a hydrogen atom and W is CO, then R 1 is other than -CH 2 CH(CH 3 ) 2 , are prepared (a) when W is CO, by hydrolysing the product of the rection between a 4-(R 2 , R 3 - phenoxy) - (R,R 4 - phenyl) - magnesium bromide and R 1 COCL or (b) when W is CHOH, by reducing the product of (a) in an inert organic solvent. Pharmaceutical compositions having hypolipidemic activity comprise, as active ingredient, a diphenyl ether of the general formula above, in association with a pharmaceutically acceptable diluent or carrier.
GB3838574A 1973-09-04 1974-09-03 Diphenyl ethers Expired GB1471012A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39418173A 1973-09-04 1973-09-04

Publications (1)

Publication Number Publication Date
GB1471012A true GB1471012A (en) 1977-04-21

Family

ID=23557898

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3838574A Expired GB1471012A (en) 1973-09-04 1974-09-03 Diphenyl ethers

Country Status (11)

Country Link
BE (1) BE819461A (en)
CA (1) CA1048934A (en)
DE (1) DE2442117A1 (en)
FR (1) FR2242078B1 (en)
GB (1) GB1471012A (en)
HK (1) HK43080A (en)
IE (1) IE39883B1 (en)
IL (1) IL45576A (en)
MY (1) MY8100141A (en)
NL (1) NL7411553A (en)
ZA (1) ZA745634B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069597A1 (en) * 1981-07-08 1983-01-12 RAYCHEM CORPORATION (a California corporation) Preparing p-phenoxy-benzoyl compounds
EP0322983A1 (en) * 1987-12-28 1989-07-05 The Dow Chemical Company Phenoxyphenoxypropionates, intermediates thereof and methods of preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069597A1 (en) * 1981-07-08 1983-01-12 RAYCHEM CORPORATION (a California corporation) Preparing p-phenoxy-benzoyl compounds
EP0322983A1 (en) * 1987-12-28 1989-07-05 The Dow Chemical Company Phenoxyphenoxypropionates, intermediates thereof and methods of preparation

Also Published As

Publication number Publication date
IL45576A (en) 1977-08-31
FR2242078A1 (en) 1975-03-28
CA1048934A (en) 1979-02-20
IE39883B1 (en) 1979-01-17
DE2442117A1 (en) 1975-03-06
IL45576A0 (en) 1974-11-29
FR2242078B1 (en) 1978-07-28
IE39883L (en) 1975-03-04
ZA745634B (en) 1976-04-28
HK43080A (en) 1980-08-22
BE819461A (en) 1975-03-03
NL7411553A (en) 1975-03-06
MY8100141A (en) 1981-12-31

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee