GB1470861A - Process of controlling foaming in continuous fermentations - Google Patents

Process of controlling foaming in continuous fermentations

Info

Publication number
GB1470861A
GB1470861A GB1061674A GB1061674A GB1470861A GB 1470861 A GB1470861 A GB 1470861A GB 1061674 A GB1061674 A GB 1061674A GB 1061674 A GB1061674 A GB 1061674A GB 1470861 A GB1470861 A GB 1470861A
Authority
GB
United Kingdom
Prior art keywords
substrate
foam
amount
march
citric acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1061674A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Priority to GB1061674A priority Critical patent/GB1470861A/en
Priority to IE501/75A priority patent/IE40765B1/en
Publication of GB1470861A publication Critical patent/GB1470861A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/02—Means for regulation, monitoring, measurement or control, e.g. flow regulation of foam
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/48—Tricarboxylic acids, e.g. citric acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Abstract

1470861 Citric acid PFIZER Ltd 7 March 1975 [8 March 1974] 10616/74 Heading C2C [Also in Division C6] In a continuous fermentation with a microorganism in a nutrient medium in which the main substrate has an antifoaming action, but in which no other antifoaming agent is added, the addition of the substrate to the fermentation broth is controlled by monitoring the amount of the foam and adding a sufficient amount of substrate to reduce the amount of foam when the foam exceeds a predetermined level. An example describes the microbiological production of citric acid by cultivation of Candida lipolytica ATCC 20228 on a C 14 -C 17 n-paraffin substrate. It is stated that the medium first begins to foam when the original hydrocarbon substrate therein has been exhausted. Further foaming occurs as each charge of substrate is used up. The requisite apparatus includes a foam probe 12 electrically connected to a control panel 13 which controls a pump or valve 14 in the substrate supply line 16. The amount of substrate added when the means is actuated may be limited by a timing device (not shown). The apparatus is fitted with an air line 3, and heater 6 and cooler 7 controlled by a temperature probe 8. Specification 1,369,295 is referred to.
GB1061674A 1974-03-08 1974-03-08 Process of controlling foaming in continuous fermentations Expired GB1470861A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB1061674A GB1470861A (en) 1974-03-08 1974-03-08 Process of controlling foaming in continuous fermentations
IE501/75A IE40765B1 (en) 1974-03-08 1975-03-07 Process of controlling foaming in continous fermentations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1061674A GB1470861A (en) 1974-03-08 1974-03-08 Process of controlling foaming in continuous fermentations

Publications (1)

Publication Number Publication Date
GB1470861A true GB1470861A (en) 1977-04-21

Family

ID=9971156

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1061674A Expired GB1470861A (en) 1974-03-08 1974-03-08 Process of controlling foaming in continuous fermentations

Country Status (2)

Country Link
GB (1) GB1470861A (en)
IE (1) IE40765B1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0231145A2 (en) * 1986-01-17 1987-08-05 Tschudin & Heid AG Device for the treatment of microorganisms and method for the operation of this device
US4752564A (en) * 1983-07-12 1988-06-21 Phillips Petroleum Company Fermentation method and apparatus
US4987082A (en) * 1988-08-05 1991-01-22 Shell Internationale Research Control of foam build up in a fermenter
WO1991001788A1 (en) * 1989-08-11 1991-02-21 Henkel Kommanditgesellschaft Auf Aktien Dosing installation for treating liquids
WO2002079374A2 (en) * 2001-03-30 2002-10-10 Gadi Steiner Fermentor volume control using defoamer and defoamer usage information
WO2023055747A1 (en) * 2021-09-29 2023-04-06 Life Technologies Corporation Adjustable foam sensor systems and related methods

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4752564A (en) * 1983-07-12 1988-06-21 Phillips Petroleum Company Fermentation method and apparatus
EP0231145A2 (en) * 1986-01-17 1987-08-05 Tschudin & Heid AG Device for the treatment of microorganisms and method for the operation of this device
EP0231145A3 (en) * 1986-01-17 1988-02-24 Tschudin & Heid AG Device for the treatment of microorganisms and method for the operation of this device
US4987082A (en) * 1988-08-05 1991-01-22 Shell Internationale Research Control of foam build up in a fermenter
WO1991001788A1 (en) * 1989-08-11 1991-02-21 Henkel Kommanditgesellschaft Auf Aktien Dosing installation for treating liquids
EP0415115A2 (en) * 1989-08-11 1991-03-06 Henkel Kommanditgesellschaft auf Aktien Dosing installation for the treatment of liquids
EP0415115A3 (en) * 1989-08-11 1991-03-27 Henkel Kommanditgesellschaft Auf Aktien Dosing installation for the treatment of liquids
WO2002079374A2 (en) * 2001-03-30 2002-10-10 Gadi Steiner Fermentor volume control using defoamer and defoamer usage information
WO2002079374A3 (en) * 2001-03-30 2004-03-18 Gadi Steiner Fermentor volume control using defoamer and defoamer usage information
WO2023055747A1 (en) * 2021-09-29 2023-04-06 Life Technologies Corporation Adjustable foam sensor systems and related methods

Also Published As

Publication number Publication date
IE40765L (en) 1975-09-08
IE40765B1 (en) 1979-08-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee