GB1464975A - Composition having local anesthetic effect - Google Patents

Composition having local anesthetic effect

Info

Publication number
GB1464975A
GB1464975A GB1056874A GB1056874A GB1464975A GB 1464975 A GB1464975 A GB 1464975A GB 1056874 A GB1056874 A GB 1056874A GB 1056874 A GB1056874 A GB 1056874A GB 1464975 A GB1464975 A GB 1464975A
Authority
GB
United Kingdom
Prior art keywords
composition
local anesthetic
diisopropylaminoethoxybutyrophenone
volume
anesthetic effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1056874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astra Lakemedel AB
Original Assignee
Astra Lakemedel AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Lakemedel AB filed Critical Astra Lakemedel AB
Publication of GB1464975A publication Critical patent/GB1464975A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

o-Diisopropylaminoethoxybutyrophenone is prepared by treating an aqueous solution of an acid addition salt of o-diisopropylaminoethoxybutyrophenone with a base. Preparations of o-diisopropylaminoethoxybutyrophenone in which it is present to at least 1 % by volume, together with 40 to 70 % by volume of isopropanol and up to 40 % by volume of glycerol, produce a deep and long-lasting anaesthesia on topical application to uninjured skin.
GB1056874A 1973-03-13 1974-03-08 Composition having local anesthetic effect Expired GB1464975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7303452A SE387536B (en) 1973-03-13 1973-03-13 PROCEDURE FOR PREPARING A LOCAL AESTHETIC PREPARATION

Publications (1)

Publication Number Publication Date
GB1464975A true GB1464975A (en) 1977-02-16

Family

ID=20316881

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1056874A Expired GB1464975A (en) 1973-03-13 1974-03-08 Composition having local anesthetic effect

Country Status (17)

Country Link
JP (1) JPS49124219A (en)
AT (1) AT333965B (en)
BE (1) BE812230A (en)
CA (1) CA1042798A (en)
CH (1) CH608783A5 (en)
DD (1) DD113694A5 (en)
DE (1) DE2410939A1 (en)
DK (1) DK136179B (en)
FI (1) FI53068C (en)
FR (1) FR2221143B1 (en)
GB (1) GB1464975A (en)
HU (1) HU167892B (en)
IE (1) IE39172B1 (en)
NL (1) NL7403079A (en)
SE (1) SE387536B (en)
SU (1) SU556718A3 (en)
ZA (1) ZA741093B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2163956A (en) * 1984-09-08 1986-03-12 Ile De France Percutaneous anaesthetic composition for topical application
WO2004080443A1 (en) 2003-03-14 2004-09-23 Epistem Limited Treatment and/or prevention of non-viral epithelial damage
WO2011027128A1 (en) 2009-09-03 2011-03-10 The University Of Manchester Use of non-digestible oligosaccharides
EP2327414A1 (en) 2002-11-07 2011-06-01 BioMarin Pharmaceutical Inc. Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2163956A (en) * 1984-09-08 1986-03-12 Ile De France Percutaneous anaesthetic composition for topical application
AU581246B2 (en) * 1984-09-08 1989-02-16 Smith & Nephew Plc Percutaneous anaesthetic composition for topical application and associated method
EP2327414A1 (en) 2002-11-07 2011-06-01 BioMarin Pharmaceutical Inc. Precursor N-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme
WO2004080443A1 (en) 2003-03-14 2004-09-23 Epistem Limited Treatment and/or prevention of non-viral epithelial damage
WO2011027128A1 (en) 2009-09-03 2011-03-10 The University Of Manchester Use of non-digestible oligosaccharides
US10265335B2 (en) 2009-09-03 2019-04-23 Curapel (Scotland) Limited Use of non-digestible oligosaccharides

Also Published As

Publication number Publication date
BE812230A (en) 1974-09-13
DE2410939A1 (en) 1974-09-19
NL7403079A (en) 1974-09-17
HU167892B (en) 1976-01-28
DD113694A5 (en) 1975-06-20
AT333965B (en) 1976-12-27
AU6623674A (en) 1975-09-04
JPS49124219A (en) 1974-11-28
ZA741093B (en) 1975-01-29
IE39172L (en) 1974-09-13
FR2221143B1 (en) 1977-04-15
CA1042798A (en) 1978-11-21
FI53068C (en) 1978-02-10
SE387536B (en) 1976-09-13
DK136179C (en) 1978-03-13
ATA172774A (en) 1976-04-15
FI53068B (en) 1977-10-31
SU556718A3 (en) 1977-04-30
DK136179B (en) 1977-08-29
CH608783A5 (en) 1979-01-31
FR2221143A1 (en) 1974-10-11
IE39172B1 (en) 1978-08-16

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee