GB1462407A - Preparation of p-isobutyl hydratropic acid and intermediates therefor - Google Patents
Preparation of p-isobutyl hydratropic acid and intermediates thereforInfo
- Publication number
- GB1462407A GB1462407A GB3236474A GB3236474A GB1462407A GB 1462407 A GB1462407 A GB 1462407A GB 3236474 A GB3236474 A GB 3236474A GB 3236474 A GB3236474 A GB 3236474A GB 1462407 A GB1462407 A GB 1462407A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formula
- isobutyl
- preparation
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- CMXNFXBFNYHFAL-UHFFFAOYSA-N 5-methylhex-1-en-3-one Chemical compound CC(C)CC(=O)C=C CMXNFXBFNYHFAL-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001760 anti-analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- XYIBRDXRRQCHLP-UHFFFAOYSA-N ethyl acetoacetate Chemical compound CCOC(=O)CC(C)=O XYIBRDXRRQCHLP-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/347—Saturated compounds containing more than one carboxyl group containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT5031574 | 1974-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1462407A true GB1462407A (en) | 1977-01-26 |
Family
ID=11272714
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3236474A Expired GB1462407A (en) | 1974-04-11 | 1974-07-22 | Preparation of p-isobutyl hydratropic acid and intermediates therefor |
Country Status (11)
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4189596A (en) | 1976-05-24 | 1980-02-19 | The Upjohn Company | Preparing 2-arylalkanoic acid derivatives |
| EP0022440A1 (en) * | 1979-06-22 | 1981-01-21 | The Upjohn Company | Process for preparing Michael addition products and for converting them to ibuprofen, an anti-inflammatory compound |
| US4476248A (en) * | 1983-02-28 | 1984-10-09 | The Upjohn Company | Crystallization of ibuprofen |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1265800A (en) * | 1917-04-07 | 1918-05-14 | Ralph Harper Mckee | Process of producing 1:2:4 methyl-hydroxy-isopropyl benzene. |
| GB1265800A (enrdf_load_stackoverflow) * | 1968-11-05 | 1972-03-08 |
-
1974
- 1974-06-12 JP JP6759574A patent/JPS5614654B2/ja not_active Expired
- 1974-06-12 JP JP6759474A patent/JPS553336B2/ja not_active Expired
- 1974-07-22 GB GB3236474A patent/GB1462407A/en not_active Expired
- 1974-07-30 FR FR7426448A patent/FR2267303B1/fr not_active Expired
- 1974-08-05 AR AR255046A patent/AR201607A1/es active
- 1974-08-30 ES ES429691A patent/ES429691A1/es not_active Expired
- 1974-09-24 BE BE148827A patent/BE820267A/xx unknown
- 1974-10-24 AT AT858674A patent/AT338251B/de not_active IP Right Cessation
- 1974-11-05 DE DE19742452459 patent/DE2452459A1/de active Pending
- 1974-11-12 NL NL7414715A patent/NL7414715A/xx not_active Application Discontinuation
- 1974-11-26 FI FI3409/74A patent/FI340974A7/fi unknown
-
1975
- 1975-01-23 CA CA218,480A patent/CA1048054A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2267303B1 (enrdf_load_stackoverflow) | 1978-03-31 |
| DE2452459A1 (de) | 1975-10-23 |
| NL7414715A (nl) | 1975-10-14 |
| ATA858674A (de) | 1976-12-15 |
| CA1048054A (en) | 1979-02-06 |
| JPS50135026A (enrdf_load_stackoverflow) | 1975-10-25 |
| ES429691A1 (es) | 1976-10-01 |
| AR201607A1 (es) | 1975-03-31 |
| JPS5614654B2 (enrdf_load_stackoverflow) | 1981-04-06 |
| FR2267303A1 (enrdf_load_stackoverflow) | 1975-11-07 |
| AT338251B (de) | 1977-08-10 |
| FI340974A7 (enrdf_load_stackoverflow) | 1975-10-12 |
| JPS50135049A (enrdf_load_stackoverflow) | 1975-10-25 |
| JPS553336B2 (enrdf_load_stackoverflow) | 1980-01-24 |
| BE820267A (fr) | 1975-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |