GB1458218A - Azabicycloalkanes and process for their preparation - Google Patents

Azabicycloalkanes and process for their preparation

Info

Publication number
GB1458218A
GB1458218A GB2767476A GB2767476A GB1458218A GB 1458218 A GB1458218 A GB 1458218A GB 2767476 A GB2767476 A GB 2767476A GB 2767476 A GB2767476 A GB 2767476A GB 1458218 A GB1458218 A GB 1458218A
Authority
GB
United Kingdom
Prior art keywords
compound
produce
nitromethylene
hal
aminomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2767476A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Science Union et Cie
Original Assignee
Science Union et Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Science Union et Cie filed Critical Science Union et Cie
Priority to GB2767476A priority Critical patent/GB1458218A/en
Publication of GB1458218A publication Critical patent/GB1458218A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1458218 Azabicycloalkanes SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 13 Dec 1974 [14 Dec 1973] 27674/76 Divided out of 1458217 Heading C2C Novel compounds of the Formula I wherein n is 0, 1 or 2, R is a saturated or unsaturated aliphatic hydrocarbon having up to 5 carbon atoms and R<SP>1</SP> is hydrogen and R<SP>2</SP> is aminomethyl or R<SP>1</SP> and R<SP>2</SP> together are oxygen or nitromethylene may be prepared by (1) reacting a compound V with a compound R-hal wherein hal is halogen, in the presence of sodium hydride to produce a compound I in which R<SP>1</SP> and R<SP>2</SP> together are oxygen, optionally followed by reaction with dimethyl sulphate, sodium methylate and nitromethane to produce a compound I in which R<SP>1</SP> and R<SP>2</SP> together are nitromethylene, optionally followed by reduction to produce a compound I in which R<SP>1</SP> is hydrogen and R<SP>2</SP> is aminomethyl. The final product may be used to prepare pharmaceutically active compounds claimed in Specification 1,458,217.
GB2767476A 1973-12-14 1973-12-14 Azabicycloalkanes and process for their preparation Expired GB1458218A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2767476A GB1458218A (en) 1973-12-14 1973-12-14 Azabicycloalkanes and process for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2767476A GB1458218A (en) 1973-12-14 1973-12-14 Azabicycloalkanes and process for their preparation

Publications (1)

Publication Number Publication Date
GB1458218A true GB1458218A (en) 1976-12-08

Family

ID=10263438

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2767476A Expired GB1458218A (en) 1973-12-14 1973-12-14 Azabicycloalkanes and process for their preparation

Country Status (1)

Country Link
GB (1) GB1458218A (en)

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee