GB1457186A - Isoquinoline derivatives and process for their manufacture - Google Patents

Isoquinoline derivatives and process for their manufacture

Info

Publication number
GB1457186A
GB1457186A GB817174A GB817174A GB1457186A GB 1457186 A GB1457186 A GB 1457186A GB 817174 A GB817174 A GB 817174A GB 817174 A GB817174 A GB 817174A GB 1457186 A GB1457186 A GB 1457186A
Authority
GB
United Kingdom
Prior art keywords
feb
therapeutic compositions
division
agents
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB817174A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of GB1457186A publication Critical patent/GB1457186A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Abstract

1457186 Therapeutic compositions HOECHST AG 22 Feb 1974 [24 Feb 1973] 8171/74 Heading A5B [Also in Division C2] Therapeutic compositions having hypolipaemic and (in some cases) hypoglycaemic activity and which are preferably administered orally, comprise (with certain exclusions: see Division C2) compounds of formula wherein X is O or S; R<SP>1</SP> is H, C 1-6 alkyl or Ph; R<SP>2</SP> is H, or R<SP>1</SP>-R<SP>2</SP> forms with the ring 4-C atom a carbocyclic 5- or 6-membered ring; R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> are each H, halogen or NO 2 ; and R<SP>6</SP>, R<SP>7</SP> are each H or C 1-4 alkoxy. Other pharmaceutically active substances which may be present are antidiabetics such as glycodiazin, tolbutamide, glibenclamide, phenformin, buformin and metformin; circulatory agents such as chromonar and prenylamine; hypotensives such as reserpin, alpha-methyldopa and clonidines; other hypolipaemics; geriatric agents; psycho-pharmaceuticals such as chlordiazepoxide, diazepan or meprobamate; and vitamins.
GB817174A 1973-02-24 1974-02-22 Isoquinoline derivatives and process for their manufacture Expired GB1457186A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732309367 DE2309367A1 (en) 1973-02-24 1973-02-24 1,4-DIHYDRO-4-H-ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION

Publications (1)

Publication Number Publication Date
GB1457186A true GB1457186A (en) 1976-12-01

Family

ID=5873034

Family Applications (1)

Application Number Title Priority Date Filing Date
GB817174A Expired GB1457186A (en) 1973-02-24 1974-02-22 Isoquinoline derivatives and process for their manufacture

Country Status (13)

Country Link
JP (1) JPS49117475A (en)
AT (1) ATA146874A (en)
AU (1) AU6593074A (en)
BE (1) BE811528A (en)
CA (1) CA1016173A (en)
DD (1) DD114408A5 (en)
DE (1) DE2309367A1 (en)
FR (1) FR2218892B1 (en)
GB (1) GB1457186A (en)
IE (1) IE38917B1 (en)
IL (1) IL44208A0 (en)
NL (1) NL7402259A (en)
ZA (1) ZA741172B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111039867A (en) * 2019-12-11 2020-04-21 四川大学 Green synthesis method of 3, 4-disubstituted isoquinoline derivative promoted by room-temperature illumination

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328052D0 (en) * 1983-10-20 1983-11-23 Beecham Group Plc Compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1354246A (en) * 1971-05-27 1974-06-05 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydro-3-2h-isoquinoline derivatives and a process for the preparation thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111039867A (en) * 2019-12-11 2020-04-21 四川大学 Green synthesis method of 3, 4-disubstituted isoquinoline derivative promoted by room-temperature illumination

Also Published As

Publication number Publication date
IL44208A0 (en) 1974-05-16
BE811528A (en) 1974-08-26
FR2218892B1 (en) 1978-01-06
AU6593074A (en) 1975-08-28
CA1016173A (en) 1977-08-23
IE38917L (en) 1974-08-24
ATA146874A (en) 1977-08-15
ZA741172B (en) 1975-01-29
DD114408A5 (en) 1975-08-05
IE38917B1 (en) 1978-06-21
DE2309367A1 (en) 1974-09-05
FR2218892A1 (en) 1974-09-20
NL7402259A (en) 1974-08-27
JPS49117475A (en) 1974-11-09

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee