IE38917B1 - Isoquinoline derivatives and process for their manufactur - Google Patents

Isoquinoline derivatives and process for their manufactur

Info

Publication number
IE38917B1
IE38917B1 IE00358/74A IE35874A IE38917B1 IE 38917 B1 IE38917 B1 IE 38917B1 IE 00358/74 A IE00358/74 A IE 00358/74A IE 35874 A IE35874 A IE 35874A IE 38917 B1 IE38917 B1 IE 38917B1
Authority
IE
Ireland
Prior art keywords
feb
therapeutic compositions
division
agents
manufactur
Prior art date
Application number
IE00358/74A
Other versions
IE38917L (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IE38917L publication Critical patent/IE38917L/en
Publication of IE38917B1 publication Critical patent/IE38917B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

1457186 Therapeutic compositions HOECHST AG 22 Feb 1974 [24 Feb 1973] 8171/74 Heading A5B [Also in Division C2] Therapeutic compositions having hypolipaemic and (in some cases) hypoglycaemic activity and which are preferably administered orally, comprise (with certain exclusions: see Division C2) compounds of formula wherein X is O or S; R<SP>1</SP> is H, C 1-6 alkyl or Ph; R<SP>2</SP> is H, or R<SP>1</SP>-R<SP>2</SP> forms with the ring 4-C atom a carbocyclic 5- or 6-membered ring; R<SP>3</SP>, R<SP>4</SP>, R<SP>5</SP> are each H, halogen or NO 2 ; and R<SP>6</SP>, R<SP>7</SP> are each H or C 1-4 alkoxy. Other pharmaceutically active substances which may be present are antidiabetics such as glycodiazin, tolbutamide, glibenclamide, phenformin, buformin and metformin; circulatory agents such as chromonar and prenylamine; hypotensives such as reserpin, alpha-methyldopa and clonidines; other hypolipaemics; geriatric agents; psycho-pharmaceuticals such as chlordiazepoxide, diazepan or meprobamate; and vitamins. [GB1457186A]
IE00358/74A 1973-02-24 1974-02-22 Isoquinoline derivatives and process for their manufactur IE38917B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732309367 DE2309367A1 (en) 1973-02-24 1973-02-24 1,4-DIHYDRO-4-H-ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION

Publications (2)

Publication Number Publication Date
IE38917L IE38917L (en) 1974-08-24
IE38917B1 true IE38917B1 (en) 1978-06-21

Family

ID=5873034

Family Applications (1)

Application Number Title Priority Date Filing Date
IE00358/74A IE38917B1 (en) 1973-02-24 1974-02-22 Isoquinoline derivatives and process for their manufactur

Country Status (13)

Country Link
JP (1) JPS49117475A (en)
AT (1) ATA146874A (en)
AU (1) AU6593074A (en)
BE (1) BE811528A (en)
CA (1) CA1016173A (en)
DD (1) DD114408A5 (en)
DE (1) DE2309367A1 (en)
FR (1) FR2218892B1 (en)
GB (1) GB1457186A (en)
IE (1) IE38917B1 (en)
IL (1) IL44208A0 (en)
NL (1) NL7402259A (en)
ZA (1) ZA741172B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8328052D0 (en) * 1983-10-20 1983-11-23 Beecham Group Plc Compounds
CN111039867A (en) * 2019-12-11 2020-04-21 四川大学 Green synthesis method of 3, 4-disubstituted isoquinoline derivative promoted by room-temperature illumination

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1354246A (en) * 1971-05-27 1974-06-05 Egyt Gyogyszervegyeszeti Gyar 1,4-dihydro-3-2h-isoquinoline derivatives and a process for the preparation thereof

Also Published As

Publication number Publication date
FR2218892B1 (en) 1978-01-06
DE2309367A1 (en) 1974-09-05
JPS49117475A (en) 1974-11-09
FR2218892A1 (en) 1974-09-20
BE811528A (en) 1974-08-26
IL44208A0 (en) 1974-05-16
AU6593074A (en) 1975-08-28
ATA146874A (en) 1977-08-15
NL7402259A (en) 1974-08-27
ZA741172B (en) 1975-01-29
IE38917L (en) 1974-08-24
DD114408A5 (en) 1975-08-05
GB1457186A (en) 1976-12-01
CA1016173A (en) 1977-08-23

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